Lithospermum erythrorhizonSuppresses High-Fat Diet-Induced Obesity, and Acetylshikonin, a Main Compound ofLithospermum erythrorhizon, Inhibits Adipocyte Differentiation

2012 ◽  
Vol 60 (36) ◽  
pp. 9089-9096 ◽  
Author(s):  
So Young Gwon ◽  
Ji Yun Ahn ◽  
Chang Hwa Chung ◽  
BoKyung Moon ◽  
Tae Youl Ha
Keyword(s):  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
High Fat ◽  
Main Compound ◽  
Diet Induced Obesity

scholarly journals Cirsium setidens Nakai extract inhibits adipocyte differentiation and High‐Fat Diet‐induced obesity in Mice

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
YoungJun Lee ◽  
Ju Hyun Cho ◽  
Bong Kyun Kim ◽  
Hyeon‐Son Choi ◽  
Boo Yong Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Obesity In Mice ◽  
Cirsium Setidens

scholarly journals Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity

2020 ◽  
Vol 52 (9) ◽  
pp. 1574-1586
Author(s):  
Youngmin Yoon ◽  
Gihyeon Kim ◽  
Myung-giun Noh ◽  
Jeong-hyeon Park ◽  
Mongjoo Jang ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Oxidative Phosphorylation ◽  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
Lactobacillus Fermentum ◽  
Metabolic Homeostasis ◽  
High Fat ◽  
Metabolome Analysis ◽  
Diet Induced Obesity ◽  
Glucose Clearance

Abstract The gut microbiota has pivotal roles in metabolic homeostasis and modulation of the intestinal environment. Notably, the administration of Lactobacillus spp. ameliorates diet-induced obesity in humans and mice. However, the mechanisms through which Lactobacillus spp. control host metabolic homeostasis remain unclear. Accordingly, in this study, we evaluated the physiological roles of Lactobacillus fermentum in controlling metabolic homeostasis in diet-induced obesity. Our results demonstrated that L. fermentum-potentiated oxidative phosphorylation in adipose tissue, resulting in increased energy expenditure to protect against diet-induced obesity. Indeed, oral administration of L. fermentum LM1016 markedly ameliorated glucose clearance and fatty liver in high-fat diet-fed mice. Moreover, administration of L. fermentum LM1016 markedly decreased inflammation and increased oxidative phosphorylation in gonadal white adipose tissue, as demonstrated by transcriptome analysis. Finally, metabolome analysis showed that metabolites derived from L. fermentum LM1016-attenuated adipocyte differentiation and inflammation in 3T3-L1 preadipocytes. These pronounced metabolic improvements suggested that the application of L. fermentum LM1016 could have clinical applications for the treatment of metabolic syndromes, such as diet-induced obesity.

scholarly journals High-fat diet-induced obesity displays altered adipocyte differentiation in the absence of Interleukin-1 Receptor I (IL-1RI)

2018 ◽  
Vol 77 (OCE4) ◽  
Author(s):  
K.A.J. Mitchelson ◽  
J.C. Ralston ◽  
C.R. Strain ◽  
Y.M. Lenighan ◽  
E.B. Kennedy ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
Interleukin 1 ◽  
High Fat ◽  
Diet Induced Obesity

Alpinia officinarum Inhibits Adipocyte Differentiation and High-Fat Diet–Induced Obesity in Mice Through Regulation of Adipogenesis and Lipogenesis

2012 ◽  
Vol 15 (11) ◽  
pp. 959-967 ◽  
Author(s):  
Chang Hwa Jung ◽  
Soo Jeong Jang ◽  
Jiyun Ahn ◽  
So Young Gwon ◽  
Tae-Il Jeon ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Alpinia Officinarum ◽  
Obesity In Mice

scholarly journals Mechanism of SEMA3G knockdown-mediated attenuation of high-fat diet-induced obesity

2020 ◽  
Vol 244 (1) ◽  
pp. 223-236 ◽  
Author(s):  
Min Liu ◽  
Shuo Xie ◽  
Weiwei Liu ◽  
Jingjin Li ◽  
Chao Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Adipocyte Differentiation ◽  
Plasma Concentrations ◽  
Axonal Guidance ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Primary Mouse

Obesity is a worldwide health problem. Semaphorins are involved in axonal guidance; however, the role of secretory semaphorin 3G (SEMA3G) in regulating adipocyte differentiation remains unclear. Microarray analysis showed that the SEMA3G gene was upregulated in an in vitro model of adipogenesis. In this study, SEMA3G was highly expressed in the white adipose tissue and liver. Analysis of 3T3-L1 cell and primary mouse preadipocyte differentiation showed that SEMA3G mRNA and protein levels were increased during the middle stage of cell development. In vitro experiments also showed that adipocyte differentiation was promoted by SEMA3G; however, SEMA3G inhibition using a recombinant lentiviral vector expressing a specific shRNA showed the opposite results. Mice were fed a chow or high-fat diet (HFD); knockdown of SEMA3G was found to inhibit weight gain, reduce fat mass in the tissues, prevent lipogenesis in the liver tissue, reduce insulin resistance and ameliorate glucose tolerance in HFD mice. Additionally, the effect of SEMA3G on HFD-induced obesity was activated through PI3K/Akt/GSK3β signaling in the adipose tissue and the AMPK/SREBP-1c pathway in the liver. Moreover, the plasma concentrations of SEMA3G and leptin were measured in 20 obese and 20 non-obese human subjects. Both proteins were increased in obese subjects, who also exhibited a lower level of adiponectin and presented with insulin resistance. In summary, we demonstrated that SEMA3G is an adipokine essential for adipogenesis, lipogenesis, and insulin resistance and is associated with obesity. SEMA3G inhibition may, therefore, be useful for treating diet-induced obesity and its complications.

Glucagon under high fat diet induced obesity

2007 ◽  
Vol 115 (S 1) ◽  
Author(s):  
LC Bollheimer ◽  
H Wobser ◽  
CE Wrede ◽  
A Schäffler ◽  
J Schölmerich ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Diet Induced Obesity
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