Formation of Phenolic Microbial Metabolites and Short-Chain Fatty Acids from Rye, Wheat, and Oat Bran and Their Fractions in the Metabolical in Vitro Colon Model

2012 ◽  
Vol 60 (33) ◽  
pp. 8134-8145 ◽  
Author(s):  
Emilia Nordlund ◽  
Anna-Marja Aura ◽  
Ismo Mattila ◽  
Tuija Kössö ◽  
Xavier Rouau ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Microbial Metabolites ◽  
Oat Bran ◽  
Chain Fatty Acids

scholarly journals Microbiota-derived metabolites inhibit Salmonella virulent subpopulation development by acting on single-cell behaviors

2021 ◽  
Vol 118 (31) ◽  
pp. e2103027118
Author(s):  
Alyson M. Hockenberry ◽  
Gabriele Micali ◽  
Gabriella Takács ◽  
Jessica Weng ◽  
Wolf-Dietrich Hardt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Single Cell ◽  
Population Level ◽  
Cell Types ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Microbial Metabolites ◽  
Molecular Approaches ◽  
Chain Fatty Acids

Salmonella spp. express Salmonella pathogenicity island 1 Type III Secretion System 1 (T3SS-1) genes to mediate the initial phase of interaction with their host. Prior studies indicate short-chain fatty acids, microbial metabolites at high concentrations in the gastrointestinal tract, limit population-level T3SS-1 gene expression. However, only a subset of Salmonella cells in a population express these genes, suggesting short-chain fatty acids could decrease T3SS-1 population-level expression by acting on per-cell expression or the proportion of expressing cells. Here, we combine single-cell, theoretical, and molecular approaches to address the effect of short-chain fatty acids on T3SS-1 expression. Our in vitro results show short-chain fatty acids do not repress T3SS-1 expression by individual cells. Rather, these compounds act to selectively slow the growth of T3SS-1–expressing cells, ultimately decreasing their frequency in the population. Further experiments indicate slowed growth arises from short-chain fatty acid–mediated depletion of the proton motive force. By influencing the T3SS-1 cell-type proportions, our findings imply gut microbial metabolites act on cooperation between the two cell types and ultimately influence Salmonella’s capacity to establish within a host.

Short-Chain Fatty Acids Prevent Diabetic Nephropathy In Vivo and In Vitro

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 92-OR ◽  
Author(s):  
WEI HUANG ◽  
YONG XU ◽  
YOUHUA XU ◽  
LUPING ZHOU ◽  
CHENLIN GAO
Keyword(s):  
Fatty Acids ◽  
Diabetic Nephropathy ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids

scholarly journals In vitro contractile effects of short chain fatty acids in the rat terminal ileum.

Gut ◽  
1996 ◽  
Vol 38 (1) ◽  
pp. 53-58 ◽  
Author(s):  
C Cherbut ◽  
A C Aube ◽  
H M Blottiere ◽  
P Pacaud ◽  
C Scarpignato ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Terminal Ileum ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Chain Fatty Acids
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