Isolation of a New Phlorotannin, a Potent Inhibitor of Carbohydrate-Hydrolyzing Enzymes, from the Brown Alga Sargassum patens

2012 ◽  
Vol 60 (22) ◽  
pp. 5565-5570 ◽  
Author(s):  
Yasuko Kawamura-Konishi ◽  
Natsuko Watanabe ◽  
Miki Saito ◽  
Noriyuki Nakajima ◽  
Toshiyuki Sakaki ◽  
...  
Keyword(s):  
Brown Alga ◽  
Potent Inhibitor ◽  
Hydrolyzing Enzymes ◽  
Sargassum Patens

Preparation and characteristics of bio-oil from the marine brown alga Sargassum patens C. Agardh

2012 ◽  
Vol 104 ◽  
pp. 737-742 ◽  
Author(s):  
Demao Li ◽  
Limei Chen ◽  
Dong Xu ◽  
Xiaowen Zhang ◽  
Naihao Ye ◽  
...  
Keyword(s):  
Brown Alga ◽  
Bio Oil ◽  
Sargassum Patens ◽  
Marine Brown Alga

Phlorofucofuroeckol-A, a potent inhibitor of aldo-keto reductase family 1 member B10, from the edible brown alga Eisenia bicyclis

2012 ◽  
Vol 55 (6) ◽  
pp. 721-727 ◽  
Author(s):  
Joo Young Lee ◽  
Sang Min Kim ◽  
Woo-Suk Jung ◽  
Dae-Geun Song ◽  
Byung-Hun Um ◽  
...  
Keyword(s):  
Brown Alga ◽  
Potent Inhibitor ◽  
Eisenia Bicyclis

790: BMP-7 is a Potent Inhibitor of Prostate Cancer Bone Metastasis in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 255-256
Author(s):  
Cyrill A. Rentsch ◽  
Jeroen Buijs ◽  
Geertje Van der Horst ◽  
Petra Van Overveld ◽  
Antoinette Wetterwald ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Potent Inhibitor

Effect of the marine brown alga Canistrocarpus cervicornis on promastigote forms of Leishmania (L.) amazonensis

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AO Santos ◽  
EA Britta ◽  
T Ueda-Nakamura ◽  
BP Dias Filho ◽  
EM Bianco ◽  
...  
Keyword(s):  
Brown Alga ◽  
Canistrocarpus Cervicornis ◽  
Marine Brown Alga

Identification of plumericin from Himatanthus Sucuuba as a novel potent inhibitor of the NF-κB pathway directly targeting IKK-β

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
B Waltenberger ◽  
N Fakhrudin ◽  
M Cabaravdic ◽  
AG Atanasov ◽  
EH Heiss ◽  
...  
Keyword(s):  
Potent Inhibitor

Isolation and Structural Charaderization of a Potent Inhibitor of Coagulation Factor Xa from the Leech Haementeria ghilianii

1989 ◽  
Vol 61 (03) ◽  
pp. 437-441 ◽  
Author(s):  
Cindra Condra ◽  
Elka Nutt ◽  
Christopher J Petroski ◽  
Ellen Simpson ◽  
P A Friedman ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Salivary Gland ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Western Blot ◽  
Potent Inhibitor ◽  
Factor Xa ◽  
Coagulation Factor ◽  
Sds Page ◽  
Bovine Factor

SummaryThe present work reports the discovery and charactenzation of an anticoagulant protein in the salivary gland of the giant bloodsucking leech, H. ghilianii, which is a specific and potent inhibitor of coagulation factor Xa. The inhibitor, purified to homogeneity, displayed subnanomolar inhibition of bovine factor Xa and had a molecular weight of approximately 15,000 as deduced by denaturing SDS-PAGE. The amino acid sequence of the first 43 residues of the H. ghilianii derived inhibitor displayed a striking homology to antistasin, the recently described subnanomolar inhibitor of factor Xa isolated from the Mexican leech, H. officinalis. Antisera prepared to antistasin cross-reacted with the H. ghilianii protein in Western Blot analysis. These data indicate that the giant Amazonian leech, H. ghilianii, and the smaller Mexican leech, H. officinalrs, have similar proteins which disrupt the normal hemostatic clotting mechanisms in their mammalian host’s blood.

A Thiazole Compound with Potential Antithrombotic Activity

1982 ◽  
Vol 47 (02) ◽  
pp. 173-176 ◽  
Author(s):  
E E Nishizawa ◽  
A R Mendoza ◽  
T Honohan ◽  
K A Annis
Keyword(s):  
Platelet Aggregation ◽  
Potent Inhibitor ◽  
Platelet Rich Plasma ◽  
Development Program ◽  
Antithrombotic Agent ◽  
Antithrombotic Activity ◽  
Thiazole Derivative ◽  
Cyclooxygenase Activity ◽  
Drug Development Program

SummaryA thiazole derivative, 4,5-bis(p-methoxyphenyl)-2-(trifluoromethyl)-thiazole was found to be a potent inhibitor of collagen-induced platelet aggregation, in vitro, using platelets from at least six species, including man. It was active in human platelet-rich plasma at a concentration of 1 ng/ml. While its antiplatelet activity was greater than that of flurbiprofen, its cyclooxygenase activity was equivalent to that of flurbiprofen. Also, compared to flurbiprofen, the thiazole had less anti-inflammatory activity in the hind-paw edema test. The thiazole derivative inhibited platelet aggregation following oral administration in five laboratory species. In the guinea pig it was active at 0.5 mg/kg. The LD50 in mice was greater than 1000 mg/kg (i.p.). This compound, which was designed through a systematic drug development program, may have high potential as an antithrombotic agent.

Sign in / Sign up

Export Citation Format

Share Document