Fresh Green Tea and Gallic Acid Ameliorate Oxidative Stress in Kainic Acid-Induced Status Epilepticus

2012 ◽  
Vol 60 (9) ◽  
pp. 2328-2336 ◽  
Author(s):  
Hsiao-Ling Huang ◽  
Chih-Cheng Lin ◽  
Kee-Ching G. Jeng ◽  
Pei-Wun Yao ◽  
Lu-Te Chuang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Gallic Acid ◽  
Kainic Acid ◽  
Green Tea

scholarly journals Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

2011 ◽  
Vol 8 (1) ◽  
pp. 57 ◽  
Author(s):  
Peiyuan F Hsieh ◽  
Chien-Wei Hou ◽  
Pei-Wun Yao ◽  
Szu-Pei Wu ◽  
Yu-Fen Peng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Kainic Acid ◽  
Cox 2

Salidroside protects against kainic acid-induced status epilepticus via suppressing oxidative stress

2016 ◽  
Vol 618 ◽  
pp. 19-24 ◽  
Author(s):  
Pei-Pei Si ◽  
Jun-Li Zhen ◽  
Yun-Lei Cai ◽  
Wen-Jing Wang ◽  
Wei-Ping Wang
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Kainic Acid

scholarly journals Melatonin Pretreatment Protects Against Status epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish

2021 ◽  
Author(s):  
Ana Caroline Salvador de Farias ◽  
Karolyne de Pieri Pickler ◽  
Henrique Teza Bernardo ◽  
Samira Leila Baldin ◽  
Eduardo Ronconi Dondossola ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Kainic Acid ◽  
Glutamate Transport ◽  
And Oxidative Stress

scholarly journals Melatonin Pretreatment Protects Against Status Epilepticus, Glutamate Transport, and Oxidative Stress Induced by Kainic Acid in Zebrafish

2021 ◽  
Author(s):  
Ana Caroline Salvador de Farias ◽  
Karolyne de Pieri Pickler ◽  
Henrique Teza Bernardo ◽  
Samira Leila Baldin ◽  
Eduardo Ronconi Dondossola ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Kainic Acid ◽  
Neuronal Damage ◽  
Glutamate Uptake ◽  
Radical Scavenging ◽  
Antioxidant Enzyme Activities ◽  
Melatonin Treatment ◽  
Zebrafish Brain ◽  
And Oxidative Stress

Abstract Status epilepticus (SE) develops from abnormal electrical discharges, resulting in neuronal damage. Current treatments include antiepileptic drugs. However, the most common drugs used to treat seizures may sometimes be ineffective and have many side effects. Melatonin is an endogenous physiological hormone that is considered an alternative treatment for neurological disorders because of its free radical scavenging property. Thus, this study aimed to determine the effects of melatonin pretreatment on SE by inducing glutamatergic hyperstimulation in zebrafish. Seizures were induced in zebrafish using kainic acid (KA), a glutamate analog, and the seizure intensity was recorded for 60 min. Melatonin treatment for 7 days showed a decrease in seizure intensity (28%), latency to reach score 5 (14 min), and duration of SE (29%). In addition, melatonin treatment attenuated glutamate transporter levels, which significantly decreased in the zebrafish brain after 12 h of KA-induced seizures. Melatonin treatment reduced the increase in oxidative stress by reactive oxygen species formation through thiobarbituric acid reactive substances and 2‘,7‘-dichiorofluorescin, induced by KA-seizure. An imbalance of antioxidant enzyme activities such as superoxide dismutase and catalase was influenced by melatonin and KA-induced seizures. Our study indicates that melatonin promotes a neuroprotective response against the epileptic profile in zebrafish. These effects could be related to the modulation of glutamatergic neurotransmission, recovery of glutamate uptake, and oxidative stress parameters in the zebrafish brain.

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