scholarly journals Osteoprotective Effect ofMonascus-fermented Dioscorea in Ovariectomized Rat Model of Postmenopausal Osteoporosis

2011 ◽  
Vol 59 (17) ◽  
pp. 9150-9157 ◽  
Author(s):  
Shen-Shih Chiang ◽  
Shang-Ping Chang ◽  
Tzu-Ming Pan
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Rat Model ◽  
Ovariectomized Rat

Contrasting effects of parathyroid hormone and insulin-like growth factor I in an aged ovariectomized rat model of postmenopausal osteoporosis

2009 ◽  
Vol 7 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Kenneth J. Ibbotson ◽  
Christopher M. Orcutt ◽  
Sharyn M. D'Souza ◽  
Carol L. Paddock ◽  
Jay A. Arthur ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Growth Factor ◽  
Postmenopausal Osteoporosis ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Chronic lead poisoning magnifies bone detrimental effects in an ovariectomized rat model of postmenopausal osteoporosis

2016 ◽  
Vol 68 (1) ◽  
pp. 47-53 ◽  
Author(s):  
Ching Ming Lee ◽  
Antonela Romina Terrizzi ◽  
Clarisa Bozzini ◽  
Adriana Emilce Piñeiro ◽  
María Inés Conti ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Lead Poisoning ◽  
Rat Model ◽  
Ovariectomized Rat

Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis

2008 ◽  
Vol 19 (10) ◽  
pp. 694-699 ◽  
Author(s):  
Latha Devareddy ◽  
Shirin Hooshmand ◽  
Julie K. Collins ◽  
Edralin A. Lucas ◽  
Sheau C. Chai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Postmenopausal Osteoporosis ◽  
Rat Model ◽  
Ovariectomized Rat

Kefir improves bone mass and microarchitecture in an ovariectomized rat model of postmenopausal osteoporosis

2014 ◽  
Vol 26 (2) ◽  
pp. 589-599 ◽  
Author(s):  
H.-L. Chen ◽  
Y.-T. Tung ◽  
C.-H. Chuang ◽  
M.-Y. Tu ◽  
T.-C. Tsai ◽  
...  
Keyword(s):  
Bone Mass ◽  
Postmenopausal Osteoporosis ◽  
Rat Model ◽  
Ovariectomized Rat

scholarly journals Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Rong-Bin Chen ◽  
Ying-Dong Yang ◽  
Kai Sun ◽  
Shan Liu ◽  
Wei Guo ◽  
...  
Keyword(s):  
Postmenopausal Osteoporosis ◽  
Signaling Pathway ◽  
Rat Model ◽  
Experimental Studies ◽  
Enrichment Analysis ◽  
Ovariectomized Rat ◽  
Active Ingredients ◽  
Active Compounds ◽  
Osteoclast Activity ◽  
Key Genes

Abstract Background Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are still unknown. Methods Ovariectomized rat model was established to validate the therapeutic effect of ZYTLF on PMOP by Micro-CT bone analysis and pathological observation. Subsequently, active ingredients of ZYTLF and corresponding putative targets were identified by online databases. Overlapping genes were first obtained from mining genes associated with PMOP and then overlapped them with the putative targets. Key genes were selected from the multiple constructed and analyzed networks. GO and KEGG pathway enrichment analysis were performed by importing the key genes to the DAVID database. Moreover, validation of the binding association between key targets and their corresponding active compounds were accomplished by AutoDock Tools and other software. Lastly, Enzyme linked immunosorbent assay (Elisa) detection and Western blot analysis were utilized to further explore the possible mechanism of ZYTLF on PMOP. Results With 129 target genes interacting with PMOP, 92 active compounds of ZYTLF corresponded to 243 targets, and 50 key genes were chosen. Network analysis revealed the top 10 active ingredients, such as quercetin and kaempferol and the top 50 key genes, such as ERα, p38 MAPK, p-AKT and TGF-β1. Enrichment analysis uncovered multiple signaling pathways, including estrogen signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway and MAPK signaling pathway. Furthermore, our finding of the foremost active compounds was tightly bound to the core proteins, which were verified by molecular docking analysis. Through experimental studies, we confirmed that the prescription of ZYTLF could ameliorate the OVX-induced bone loss, suppress the osteoclast activity and boost osteoblast ability through experimental studies. Conclusion The potential mechanisms and therapeutic effects of ZYTLF against PMOP may be ascribed to inhibition of osteoclast activity, boost of osteoblast activity and enhancement of the expression of ERα.

scholarly journals Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

2009 ◽  
Vol 24 (4) ◽  
pp. 578-588 ◽  
Author(s):  
Xiaodong Li ◽  
Michael S Ominsky ◽  
Kelly S Warmington ◽  
Sean Morony ◽  
Jianhua Gong ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Mass ◽  
Postmenopausal Osteoporosis ◽  
Bone Strength ◽  
Rat Model ◽  
Antibody Treatment ◽  
Sclerostin Antibody

Effect of Intermittent and Daily Regimens of Minodronic Acid on Bone Metabolism in an Ovariectomized Rat Model of Osteoporosis

2014 ◽  
Vol 95 (2) ◽  
pp. 166-173 ◽  
Author(s):  
Makoto Tanaka ◽  
Hiroshi Mori ◽  
Ryoji Kayasuga ◽  
Yasuo Ochi ◽  
Hiroyuki Yamada ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Minodronic Acid
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