A Black Soybean Seed Coat Extract Prevents Obesity and Glucose Intolerance by Up-regulating Uncoupling Proteins and Down-regulating Inflammatory Cytokines in High-Fat Diet-Fed Mice

2011 ◽  
Vol 59 (16) ◽  
pp. 8985-8993 ◽  
Author(s):  
Yuki Kanamoto ◽  
Yoko Yamashita ◽  
Fumio Nanba ◽  
Tadashi Yoshida ◽  
Takanori Tsuda ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Glucose Intolerance ◽  
Seed Coat ◽  
High Fat Diet ◽  
Soybean Seed ◽  
Uncoupling Proteins ◽  
High Fat ◽  
Black Soybean ◽  
Soybean Seed Coat

Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice

2018 ◽  
Vol 9 (1) ◽  
pp. 426-439 ◽  
Author(s):  
Zhongqin Chen ◽  
Cong Wang ◽  
Yuxiang Pan ◽  
Xudong Gao ◽  
Haixia Chen
Keyword(s):  
Seed Coat ◽  
High Fat Diet ◽  
Soybean Seed ◽  
Diabetic Mice ◽  
High Fat ◽  
Black Soybean ◽  
Soybean Seed Coat

This study demonstrated the hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean in vitro and in vivo.

scholarly journals Validation of Antiobesity Effects of Black Soybean Seed Coat Powder Suitable as a Food Material: Comparisons with Conventional Yellow Soybean Seed Coat Powder

Foods ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 841
Author(s):  
Yuuki Moriyasu ◽  
Chiho Fukumoto ◽  
Maki Wada ◽  
Erika Yano ◽  
Hiroshi Murase ◽  
...  
Keyword(s):  
Seed Coat ◽  
High Fat Diet ◽  
Body Weight Gain ◽  
Soybean Seed ◽  
High Fat ◽  
Food Material ◽  
Black Soybean ◽  
Diet Induced Obesity ◽  
Model Mouse ◽  
Soybean Seed Coat

In this study, we fed obese model mice black soybean seed coat powder (BSCP) and evaluated the antiobesity effects. As a control, normal yellow soybean seed coat powder (YSCP) was used. C57BL/6J, a high-fat diet-induced obesity model mouse, was fed a high-fat diet containing BSCP or YSCP (20% fat) to induce obesity. The results showed that in the BSCP group, it caused significant suppression of body weight gain and suppression of white adipose tissue weight compared with the YSCP group. Moreover, it significantly decreased serum leptin levels, which correlated with visceral fat mass, and increased antidiabetic adipocytokine and adiponectin levels. Therefore, this suggests the pigmented components contained in BSCP have an antiobesity effect in obese model mice. It is suggested that this material, which can be prepared without extraction with an organic solvent and is suitable for use as a food material, could be a functional food material with a practicable antiobesity effect.

scholarly journals Punctual mutations in lipoxygenase sequence expressed in black soybean seed coat

2013 ◽  
Vol 35 (2) ◽  
pp. 236-239
Author(s):  
Liliane Marcia Mertz ◽  
Fernando Augusto Henning ◽  
Ana Paula Piccinin Barbieri ◽  
Samantha Rigo Segalin ◽  
Francisco Carlos Krzyzanowski ◽  
...  
Keyword(s):  
Seed Coat ◽  
Soybean Seed ◽  
Soybean Seeds ◽  
Phenotypic Characteristics ◽  
Multiple Sequence ◽  
Black Soybean ◽  
Phenotypic Differences ◽  
Seed Physiology ◽  
Soybean Seed Coat ◽  
Allelic Variations

Lipoxygenase enzymes are relevant in several characteristics of soybean seeds, such as germination performance, storage capacity and tolerance to infection by microorganisms. In this sense, the study of allelic variations of the genes related to that enzyme may be promising for the development of molecular markers associated with phenotypic characteristics which are relevant to seed physiology. This study aimed to identify mutations in lipoxygenase sequence expressed in black soybean seed coat. After isolation of the sequence of interest by the cDNA-AFLP technique, such sequence was compared with sequences of nucleotides and proteins of the lipoxygenase present in yellow soybean seed coat. Analysis of multiple sequence alignment has shown an expressive number of changes in the sequence of nucleotides, which have resulted in the modification of 13 amino acids in the translated protein. The identification of such mutations widens the possibility for further studies involving the association of these allelic variations with phenotypic differences of interest to seeds physiology.

scholarly journals Preventive Effects of Black Soybean Seed Coat Polyphenols against DNA Damage in Salmonella typhimurium

2013 ◽  
Vol 19 (4) ◽  
pp. 685-690 ◽  
Author(s):  
Tianshun ZHANG ◽  
Kyuichi KAWABATA ◽  
Rei KITANO ◽  
Hitoshi ASHIDA
Keyword(s):  
Dna Damage ◽  
Salmonella Typhimurium ◽  
Seed Coat ◽  
Soybean Seed ◽  
Black Soybean ◽  
Soybean Seed Coat ◽  
Preventive Effects

Black soybean seed coat containing diet enhancing the growth performance of juvenile hybrid tilapiaOrechromis nitoticus×O. aureus

2016 ◽  
Vol 48 (5) ◽  
pp. 2593-2601
Author(s):  
Meng-Chuan Hsieh ◽  
Chen-Huei Huang ◽  
Huai-wen Yang ◽  
Jyh-Cheng Chen ◽  
Cheng-Kuang Hsu
Keyword(s):  
Growth Performance ◽  
Seed Coat ◽  
Soybean Seed ◽  
Black Soybean ◽  
Soybean Seed Coat

Anthocyanins From Black Soybean Seed Coat Enhance Wound Healing

2013 ◽  
Vol 71 (4) ◽  
pp. 415-420 ◽  
Author(s):  
Lianji Xu ◽  
Tae Hyun Choi ◽  
Sukwha Kim ◽  
Sang-Hyon Kim ◽  
Hyuk Won Chang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Seed Coat ◽  
Soybean Seed ◽  
Black Soybean ◽  
Soybean Seed Coat ◽  
Enhance Wound Healing

scholarly journals Black soybean seed coat polyphenols promote nitric oxide production in the aorta through the Akt/eNOS pathway

2020 ◽  
Vol 10 (8) ◽  
pp. 330
Author(s):  
Chiaki Domae ◽  
Hitoshi Ashida ◽  
Yoko Yamashita
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Seed Coat ◽  
Vascular Endothelial Cells ◽  
Soybean Seed ◽  
No Production ◽  
Vascular Endothelial ◽  
Intestinal Epithelial ◽  
Black Soybean ◽  
Soybean Seed Coat

Background: Black soybean seed coat contains an abundance of flavan-3-ols and possesses various bioregulatory functions. Nitric oxide (NO) is produced by endothelial nitric oxide synthase (eNOS) in vascular endothelial cells and regulates vascular function through vasodilation and the inhibition of platelet aggregation in blood vessels. It has been reported that flavan-3-ols increase NO production, but many previous reports used a high concentration of flavan-3-ols. In the present study, we investigated the effect of flavan-3-ol-rich black soybean seed coat extract (BE) on NO production at a lower concentration that is close to the concentration after permeation through the monolayer of Caco-2 cells.Methods: Human umbilical vein endothelial cells (HUVEC) were incubated with BE, and then NO production in the medium and eNOS phosphorylation in the cells were examined. Intestinal epithelial Caco-2 cells on the upper side of a transwell filter were co-cultured with HUVEC on the basolateral compartment of the transwell apparatus. BE was added from the upper side, and the basolateral medium was collected to measure the concentration of NO and the content of flavan-3-ols. Furthermore, HUVEC were incubated with each flavan-3-ol in order to individuate the most effective compound in BE.Results: BE significantly increased NO production in the medium of HUVEC. When polyphenols in BE were removed from the basolateral medium by ethyl acetate extraction, increased NO production from HUVEC was not observed. Additionally, BE increased phosphorylation of eNOS and Akt in HUVEC. A portion of flavan-3-ols in BE had permeated through intestinal epithelial cells. Among the flavan-3-ols that had permeated, procyanidin C1 had the strongest effect on NO production in HUVEC at the concentration that had permeated the monolayer of Caco-2 cells. Procyanidin C1 (0.05 µM) also induced phosphorylation of eNOS and Akt in HUVEC without affecting the cAMP level. Conclusion: A portion of flavan-3-ols in BE directly promoted NO production through the Akt/eNOS pathway in vascular endothelial cells. These findings suggest that flavan-3-ols in the black soybean seed coat may contribute to improve the vascular function.Keywords: Black soybean seed coat polyphenols; NO; eNOS; Akt; vascular endothelial cells

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