A 4-Week Repeated Oral Dose Toxicity Study of Dairy Fat Naturally Enriched in Vaccenic, Rumenic and α-Linolenic Acids in Rats

2011 ◽  
Vol 59 (14) ◽  
pp. 8036-8046 ◽  
Author(s):  
Arturo Anadón ◽  
María Rosa Martínez-Larrañaga ◽  
María Aranzazu Martínez ◽  
Irma Ares ◽  
Eva Ramos ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Study ◽  
Dairy Fat

scholarly journals Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1126
Author(s):  
Dong-Gu Kim ◽  
Jeonghoon Lee ◽  
Wonnam Kim ◽  
Hyo-Jin An ◽  
Jong-Hyun Lee ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Oral Dose ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
New Variety ◽  
General Toxicity ◽  
Normal Ranges ◽  
Target Organs ◽  
Adverse Effect Level ◽  
Tract Infections

The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharmacological effects. However, the potential adverse effects of WG have not been revealed yet. This study evaluates the general toxicity of the WG extract through a single and repeated oral dose toxicity study in Sprague-Dawley rats. After single oral dose administration, no significant toxicological changes or mortality was observed up to 5000 mg/kg. Over a 4-week repeated oral dose toxicity study, no adverse effects and target organs were observed up to 5000 mg/kg/day. Over a 13-week repeated oral dose toxicity study, no mortality or toxicological changes involving ophthalmology, water consumption, or hematology were observed up to 5000 mg/kg/day. Although other parameters were changed, the alterations in question were not considered toxicologically significant, since responses remained within normal ranges and were not dose-dependent. In conclusion, the no-observed-adverse-effect level (NOAEL) of WG was higher than 5000 mg/kg/day, and no target organs were identified in rats.

Acute and subacute (20-d) oral dose toxicity study of modified fluoroquinolone compound 6C in BALB/c mice

Toxin Reviews ◽  
2015 ◽  
Vol 34 (3) ◽  
pp. 129-135 ◽  
Author(s):  
Abdallah Faisal Khasawneh ◽  
Kamal Abdelhameed Al-Hadidi ◽  
Talal Ahmad Aburjai ◽  
Fatimah Noory Obeidat
Keyword(s):  
Oral Dose ◽  
Toxicity Study

Acute and twenty-eight days repeated oral dose toxicity study of besifloxacin in Wistar albino rats

2011 ◽  
Vol 32 (1) ◽  
pp. 82-101 ◽  
Author(s):  
Bikash Roy ◽  
Utpal Nandi ◽  
Anjan Das ◽  
Tapan Kumar Pal
Keyword(s):  
Oral Dose ◽  
Toxicity Study ◽  
Albino Rats ◽  
Wistar Albino Rats

A 150-day oral dose toxicity study of aspirin eugenol ester in Wistar rats

2017 ◽  
Vol 280 ◽  
pp. S131
Author(s):  
Xiaole Zhao ◽  
Xiaojun Kong ◽  
Xiwang Liu ◽  
Yajun Yang ◽  
Ning Ma ◽  
...  
Keyword(s):  
Oral Dose ◽  
Wistar Rats ◽  
Toxicity Study ◽  
Aspirin Eugenol Ester

scholarly journals A 28-day repeated oral dose toxicity study of enniatin complex in mice

2021 ◽  
Vol 46 (4) ◽  
pp. 157-165
Author(s):  
Hiromu Okano ◽  
Toshiya Okamura ◽  
Yasunori Takahashi ◽  
Kazumi Takashima ◽  
Ryota Ojiro ◽  
...  
Keyword(s):  
Oral Dose ◽  
Toxicity Study

scholarly journals Acute and subacute toxicity evaluation of hydroalcoholic extract from the stem bark of Bois Bande (Parinari campestris Aubl.1772) in rats

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Venkatesan Sundaram ◽  
Stephanie Mohammed ◽  
M. R. Srinivasan ◽  
Jenelle Johnson ◽  
Rod Suepaul ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Oral Dose ◽  
Conventional Medicine ◽  
Sperm Count ◽  
Scientific Data ◽  
The Body ◽  
Toxicity Study ◽  
Hydroalcoholic Extract ◽  
Subacute Toxicity ◽  
Acute Toxicity Study

Abstract Introduction The bark of Bois Bande (Parinari campestris) is a popular aphrodisiac in the Caribbean that has been traditionally used for many years to restore sexual vitality, increase sperm count, and treat erectile dysfunction, without valid scientific data. Acute and 28-day subacute toxicity studies were conducted to evaluate the safety of the hydroalcoholic extract of P.campestris bark and to find a safe dose for human use in conventional medicine. Methods The acute toxicity study used a single oral dose of P.campestris extract at four separate doses, 5, 50, 300, and 2,000 mg/kg, and was seen for 14 days, while the subacute toxicity study used a daily oral dose of P.campestris extract at 3 different doses, 100, 300, and 1000 mg/kg/day for 28 days. Results The LD50 of P.campestris extract was found to be greater than 2000 mg/kg in the acute toxicity study. P.campestris extract did not show toxicity at 1000 mg/kg/day in subacute toxicity trial; NOAEL was 1000 mg/kg/day in rats. However, the body weight was increased in males. Conclusion In conclusion, 1000 mg/kg P.campestris extract can be considered safe and non-toxic in males.

scholarly journals Single and Repeated Dose 28-Day and 13-Week Toxicity Studies of Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis) in Mice

Foods ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 691
Author(s):  
Koki Sugimoto ◽  
Toshifumi Tanizaki ◽  
Eito Shimizu ◽  
Ryota Hosomi ◽  
Kenji Fukunaga ◽  
...  
Keyword(s):  
Oral Dose ◽  
Clinical Signs ◽  
Toxicity Study ◽  
Toxic Substances ◽  
Food Ingredient ◽  
Internal Organs ◽  
Experimental Conditions ◽  
Patinopecten Yessoensis ◽  
Food Ingredients ◽  
Toxicity Studies

Internal organs of discarded scallops are rich in omega-3 polyunsaturated fatty acids, but it is not used as a food ingredient due to the presence of toxic substances. Recently, our research team prepared high-quality scallop oil (SCO) from the internal organs of the Japanese giant scallop (Patinopecten yessoensis), in which cadmium and diarrhetic shellfish toxin are below regulated levels. In this study, SCO was prepared from the internal organs of scallops obtained from Mutsu and Uchiura bays in Japan, and was referred to as SCO-M (scallop oil from Mutsu bay) and SCO-U (scallop oil from Uchiura bay), respectively. Acute and subacute toxicity studies were performed to assess the safety of the prepared SCO. In acute toxicity study, mice were orally administered SCO-M and SCO-U at a single dose of 5,000 mg/kg body weight. In a 28-day repeated oral dose toxicity study, the mice were fed diets containing 1% and 5% SCO-M and SCO-U; and in a 13-week repeated oral dose toxicity study, the mice were fed 5% SCO-M and SCO-U. There were no toxicologically significant changes in clinical signs, hematology, blood chemistry, and organ weights at any dose during the experiment. Therefore, it was concluded that SCO-M and SCO-U are safe for use as food ingredients under the experimental conditions of this study.

Sign in / Sign up

Export Citation Format

Share Document