Correction to Consumption ofS-Allylcysteine Inhibits the Growth of Human Non-Small-Cell Lung Carcinoma in a Mouse Xenograft Model

2011 ◽  
Vol 59 (7) ◽  
pp. 3440-3440
Author(s):  
Feng-Yao Tang ◽  
En-Pei Chiang ◽  
Man-Hui Pai
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Xenograft Model ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Mouse Xenograft ◽  
Mouse Xenograft Model

scholarly journals Investigation of proNT/NMN secretion from small cell lung carcinoma cells using a mouse xenograft model

2012 ◽  
Vol 28 (4) ◽  
pp. 1181-1186 ◽  
Author(s):  
KANAKO WAKABAYASHI-NAKAO ◽  
KOJI MARUYAMA ◽  
HIDEE ISHII ◽  
KOJI MURAMATSU ◽  
KEIICHI HATAKEYAMA ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Xenograft Model ◽  
Small Cell ◽  
Carcinoma Cells ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Mouse Xenograft ◽  
Lung Carcinoma Cells ◽  
Mouse Xenograft Model

scholarly journals Toxoplasma GRA16 Inhibits NF-κB Activation through PP2A-B55 Upregulation in Non-Small-Cell Lung Carcinoma Cells

2020 ◽  
Vol 21 (18) ◽  
pp. 6642
Author(s):  
Seung-Hwan Seo ◽  
Sang-Gyun Kim ◽  
Ji-Hun Shin ◽  
Do-Won Ham ◽  
Eun-Hee Shin
Keyword(s):  
Cell Cycle ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Xenograft Model ◽  
Cyclin B1 ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Anticancer Effects ◽  
Mouse Xenograft Model

Nuclear factor kappa B (NF-κB) activation is a well-known mechanism by which chemoresistance to anticancer agents is reported. It is well-known that irinotecan as a chemotherapeutic drug against non-small-cell lung carcinoma (NSCLC) has limited anticancer effect due to NF-κB activation. In this study, we propose the novel role of GRA16, a dense granule protein of Toxoplasma gondii, as an anticancer agent to increase the effectiveness of chemotherapy via the inhibition of NF-κB activation. To demonstrate this, H1299 cells were stably transfected with GRA16. The anticancer effects of GRA16 were demonstrated as a reduction in tumor size in a mouse xenograft model. GRA16 directly elevated B55 regulatory subunit of protein phosphatase 2A (PP2A-B55) expression in tumor cells, thereby decreasing GWL protein levels and ENSA phosphorylation. This cascade, in turn, induced PP2A-B55 activation and suppressed AKT/ERK phosphorylation and cyclin B1 levels, suggesting reduced cell survival and arrested cell cycle. Moreover, PP2A-B55 activation and AKT phosphorylation inhibition led to NF-κB inactivation via the reduction in inhibitory kappa B kinase beta (IKKβ) levels, de-phosphorylation of inhibitor of kappa B alpha (IκBα), and reduction in the nuclear transit of NF-κB p65. Furthermore, this molecular mechanism was examined under irinotecan treatment. The PP2A-B55/AKT/NF-κB p65 pathway-mediated anticancer effects were only induced in the presence of GRA16, but not in the presence of irinotecan. Moreover, GRA16 synergistically promoted the anticancer effects of irinotecan via the induction of the sub-G1 phase and reduction of cell proliferation. Collectively, irinotecan and GRA16 co-treatment promotes the anticancer effects of irinotecan via NF-κB inhibition and cell cycle arrest induced by GRA16, subsequently increasing the chemotherapeutic effect of irinotecan to NSCLC cells via NF-κB inhibition.

Targeting Tyrosine Phosphorylation of HEXIM1 Attenuates Non-Small Cell Lung Carcinoma in Xenograft Model of Lung Cancer

2019 ◽  
Vol 229 (4) ◽  
pp. e210-e211
Author(s):  
Mohammad Choudhary ◽  
Eduardo Mascareno ◽  
Manya Dhar-Mascareno ◽  
Renato Perez-Pena ◽  
Daniel L. Beckles
Keyword(s):  
Lung Cancer ◽  
Tyrosine Phosphorylation ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Xenograft Model ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma

Clinical Features And Outcomes Of Patients With Small Cell Lung Carcinoma; Retrospective Analysis

2015 ◽  
Vol 3 (2) ◽  
pp. 47 ◽  
Author(s):  
Duygu Unalmış ◽  
Zehra Yasar ◽  
Melih Buyuksirin ◽  
Gulru Polat ◽  
Fatma Demirci Ucsular ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Clinical Features ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma
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