Irradiation Stability of Folic Acid in Powder and Aqueous Solution

2011 ◽  
Vol 59 (4) ◽  
pp. 1244-1248 ◽  
Author(s):  
Michel M. Araújo ◽  
Eric Marchioni ◽  
Martine Bergaentzle ◽  
Minjie Zhao ◽  
Florent Kuntz ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Folic Acid

Self Association of Folic Acid in Aqueous Solution by Proton Magnetic Resonance

1972 ◽  
Vol 50 (14) ◽  
pp. 2357-2363 ◽  
Author(s):  
Yui-Fai Lam ◽  
George Kotowycz
Keyword(s):  
Aqueous Solution ◽  
Folic Acid ◽  
Magnetic Resonance ◽  
Proton Magnetic Resonance ◽  
Chemical Shifts ◽  
Disodium Salt ◽  
Intermolecular Association ◽  
Self Association ◽  
Hydrophobic Portion ◽  
Proton Chemical Shifts

Proton magnetic resonance experiments on the disodium salt of folic acid in aqueous solutions (pD 7.1) indicate that the folate ion exists in an unfolded, extended conformation in solution. However, based on a temperature and concentration dependence of the proton chemical shifts, folate ions are involved in intermolecular association consisting of a vertical stacking interaction. A stacking model is proposed for the association with the hydrophilic ends of the molecule alternating in orientation with respect to the hydrophobic portion of the neighboring molecules.

Fluorescence of pterin, 6-formylpterin, 6-carboxypterin and folic acid in aqueous solution: pH effects

2002 ◽  
Vol 1 (6) ◽  
pp. 421-426 ◽  
Author(s):  
Andrés H. Thomas ◽  
Carolina Lorente ◽  
Alberto L. Capparelli ◽  
Megh Raj Pokhrel ◽  
André M. Braun ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Folic Acid ◽  
Ph Effects ◽  
Solution Ph

Effect of riboflavin on the photolysis of folic acid in aqueous solution

2000 ◽  
Vol 23 (6) ◽  
pp. 1039-1044 ◽  
Author(s):  
M Jamil Akhtar ◽  
M Ataullah Khan ◽  
Iqbal Ahmad
Keyword(s):  
Aqueous Solution ◽  
Folic Acid

scholarly journals Mechanism of folic acid radiolysis in aqueous solution

LWT ◽  
2015 ◽  
Vol 63 (1) ◽  
pp. 599-603 ◽  
Author(s):  
Michel M. Araújo ◽  
Eric Marchioni ◽  
Anna Lucia C.H. Villavicencio ◽  
Minjie Zhao ◽  
Thomas di Pascoli ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Folic Acid

Photodegradation of folic acid in aqueous solution

1999 ◽  
Vol 19 (3-4) ◽  
pp. 269-275 ◽  
Author(s):  
M.Jamil Akhtar ◽  
M.Ataullah Khan ◽  
Iqbal Ahmad
Keyword(s):  
Aqueous Solution ◽  
Folic Acid

scholarly journals Molecular dynamics simulation study of doxorubicin adsorption on functionalized carbon nanotubes with folic acid and tryptophan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tahereh Arabian ◽  
Sepideh Amjad-Iranagh ◽  
Rouein Halladj
Keyword(s):  
Carbon Nanotubes ◽  
Molecular Dynamics ◽  
Aqueous Solution ◽  
Folic Acid ◽  
Drug Release ◽  
Functional Groups ◽  
Dynamics Simulation ◽  
Repulsive Interaction ◽  
Functionalized Carbon Nanotubes ◽  
Ph Variation

AbstractIn this work, molecular dynamics (MD) simulation is used to study the adsorption of the anticancer drug, doxorubicin (DOX), on the wall or surface of pristine and functionalized carbon nanotubes (FCNTs) in an aqueous solution. Initially, the CNTs were functionalized by tryptophan (Trp) and folic acid (FA), and then the DOX molecules were added to the system. The simulation results showed that the drug molecules can intensely interact with the FCNTs at physiological pH. Furthermore, it was found that as a result of functionalization, the solubility of FCNTs in an aqueous solution increases significantly. The effect of pH variation on drug release from both pristine and FCNTs was also investigated. The obtained results indicated that in acidic environments due to protonation of functional groups (Trp) and as a result of repulsive interaction between the DOX molecule and functional groups, the release of DOX molecules from FCNT’s surface is facilitated. The drug release is also strongly dependent on the pH and protonated state of DOX and FCNT.

scholarly journals Functionalized Folic Acid-Chitosan Nanoparticles for Encapsulation of Dietary Polyphenols

2018 ◽  
Author(s):  
P. Chanphai ◽  
H.A. Tajmir-Riahi
Keyword(s):  
Aqueous Solution ◽  
Folic Acid ◽  
Structural Analysis ◽  
Chitosan Nanoparticles ◽  
Spectroscopic Methods ◽  
Dietary Polyphenols

Encapsulation of antioxidant polyphenols leads to increase solubility and bioavailability of these micronutrients in solution. The encapsulation of antioxidant resveratrol, genistein and curcumin by folic acid-chitosan nanocapsules was studied in aqueous solution, using multiple spectroscopic methods, TEM images. Structural analysis showed that polyphenol bindings are via hydrophilic, hydrophobic and H-bonding contacts with resveratrol forming more stable conjugates. As chitosan size increased, the binding efficacy and stability of polyphenol-polymer adducts were increased. Polyphenol binding induced major alterations of chitosan morphology. Chitosan nanoparticles are capable of delivery of polyphenols in vitro.

The Morphology of the Rat Kidney Following Folic Acid Administration

1970 ◽  
Vol 28 ◽  
pp. 200-201
Author(s):  
Aline Byrnes ◽  
Elsa E. Ramos ◽  
Minoru Suzuki ◽  
E.D. Mayfield
Keyword(s):  
Folic Acid ◽  
De Novo ◽  
Specific Activity ◽  
Rat Kidney ◽  
Present Report ◽  
Intracellular Localization ◽  
Male Rats ◽  
Renal Hypertrophy ◽  
Electron Microscopic ◽  
Biochemical Alterations

Renal hypertrophy was induced in 100 g male rats by the injection of 250 mg folic acid (FA) dissolved in 0.3 M NaHCO3/kg body weight (i.v.). Preliminary studies of the biochemical alterations in ribonucleic acid (RNA) metabolism of the renal tissue have been reported recently (1). They are: RNA content and concentration, orotic acid-c14 incorporation into RNA and acid soluble nucleotide pool, intracellular localization of the newly synthesized RNA, and the specific activity of enzymes of the de novo pyrimidine biosynthesis pathway. The present report describes the light and electron microscopic observations in these animals. For light microscopy, kidney slices were fixed in formalin, embedded, sectioned, and stained with H & E and PAS.

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