Synthesis, Insecticidal Activity, and Structure−Activity Relationship of Trifluoromethyl-Containing Phthalic Acid Diamide Structures

2010 ◽  
Vol 58 (20) ◽  
pp. 10999-11006 ◽  
Author(s):  
Mei-Li Feng ◽  
Yu-Feng Li ◽  
Hong-Jun Zhu ◽  
Liang Zhao ◽  
Bin-Bin Xi ◽  
...  
Keyword(s):  
Insecticidal Activity ◽  
Phthalic Acid ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of

scholarly journals Synthesis and Insecticidal Activity of β-Dihydroagarofuran Acetal Derivatives

2018 ◽  
Vol 13 (4) ◽  
pp. 1934578X1801300
Author(s):  
Xin Xi ◽  
Ximei Zhao ◽  
Feng Zhu ◽  
Jielu Wei ◽  
Zhan Hu ◽  
...  
Keyword(s):  
Insecticidal Activity ◽  
Structure Activity Relationship ◽  
Positive Control ◽  
Activity Relationship ◽  
Structure Activity ◽  
Mythimna Separate ◽  
Relationship Of ◽  
Insecticidal Compounds ◽  
Insecticidal Activities

To search for improved insecticidal compounds based on β-dihydroagarofuran sesquiterpenoids, forty-four β-dihydroagarofuran acetal derivatives were designed and synthesized. Insecticidal activities and structure-activity relationship of these target compounds were evaluated. Some of the newly synthesized β-dihydroagarofuran acetal compounds were found to show higher insecticidal activity against sixth-instar larvae of Mythimna separate. Especially, compounds 2.2.9, 2.2.10, 2.2.11, 2.3.4, 2.3.6, 2.3.7, 2.5.4, 2.5.7 had great insecticidal activities with lower LD50 than that of the positive control celangulin-V (110.13 μg/g). It deserves mentioning that compound 2.2.11 showed the lowest LD50 (60.33 μg/g) among these compounds. Structure-activity relationship results suggested that the substituent groups of 1-, 6- and 9-positions of the target structures could greatly affect the insecticidal activity. Especially, when the substituent groups of 6-position were n-propyl, n-butyl, allyl, propargyl, o-fluorobenzyl, and p-fluorobenzyl, the compounds showed outstanding insecticidal activities.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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