Synthesis of Structured Lipids Containing Medium-Chain and Omega-3 Fatty Acids

2006 ◽  
Vol 54 (12) ◽  
pp. 4390-4396 ◽  
Author(s):  
Fayez Hamam ◽  
Fereidoon Shahidi
Keyword(s):  
Fatty Acids ◽  
Structured Lipids ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Medium Chain

scholarly journals Severe Familial Hypertriglyceridemia: Successful Treatment With Insulin and a Modified Meal Plan

2018 ◽  
Vol 2 (12) ◽  
pp. 1357-1362
Author(s):  
Ahila Ayyavoo ◽  
Palany Raghupathy ◽  
Meenal Agarwal ◽  
Paul Hofman
Keyword(s):  
Fatty Acids ◽  
Insulin Infusion ◽  
Therapeutic Option ◽  
Medium Chain Triglyceride ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Medium Chain ◽  
Young Infants ◽  
Severe Hypertriglyceridemia ◽  
Meal Plan

Abstract Context Mutations in genes encoding the lipoprotein lipase enzyme, its cofactor, or transport proteins can cause severe familial hypertriglyceridemia, resulting in serious complications, such as severe pancreatitis, hepatosplenomegaly, lipid encephalopathy, and failure to thrive. Current treatment includes a low-saturated-fat formula enriched with high medium-chain triglyceride (TGs), oral fibrates, omega-3 fatty acids, or plasmapheresis. Case Description A 71-day-old infant with very severe hypertriglyceridemia and recurrent pancreatitis associated with a likely pathogenic variant in the LPL gene was treated successfully with insulin infusion and a locally prepared low-fat formula feed after stopping breast milk. Subcutaneous insulin was administered daily from 9 to 30 months of age. His serum TG level was markedly lower, although higher than normal. No episodes of hypoglycemia were noted. Fenofibrate and omega-3 fatty acids were ineffective in this infant. At the last follow-up visit, he was 36 months old and growing normally. He was consuming a special meal plan and receiving insulin injections during high-fat meals. Two other young infants with severe hypertriglyceridemia were growing normally after a short course of insulin infusion and the same modified reduced long chain fat diet. Conclusions Insulin is an unusual and affordable therapeutic option for some patients with severe hypertriglyceridemia and can be helpful in the prevention of acute and chronic complications. Locally available cereals and millets with high crude fiber and a low glycemic index, along with medium chain TGs, was used to prepare an economical special formula at home to maintain TG concentrations in the acceptable limits.

Lipase-catalysed synthesis of palm oil-omega-3 structured lipids

2019 ◽  
Vol 10 (6) ◽  
pp. 3142-3149 ◽  
Author(s):  
Qiuyu Xia ◽  
Taiwo O. Akanbi ◽  
Rui Li ◽  
Bo Wang ◽  
Wenrong Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Palm Oil ◽  
Saturated Fatty Acids ◽  
Structured Lipids ◽  
Rhizomucor Miehei ◽  
Candida Antarctica ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Lipase A

Candida antarctica lipase A was applied to selectively remove saturated fatty acids from palm oil. Rhizomucor miehei lipase was then used to add EPA or ALA into the partially hydrolyzed palm oil to produce new palm oil structured lipids containing approximately 30% omega-3 fatty acids.

Successful Treatment of Severe Hypertriglyceridemia with a Formula Diet Rich in Omega–3 Fatty Acids and Medium-Chain Triglycerides

2010 ◽  
Vol 56 (3) ◽  
pp. 170-175 ◽  
Author(s):  
Annette Hauenschild ◽  
Reinhard G. Bretzel ◽  
Henning Schnell-Kretschmer ◽  
Hans-Ulrich Kloer ◽  
Philip D. Hardt ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Successful Treatment ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Medium Chain Triglycerides ◽  
Formula Diet ◽  
Medium Chain ◽  
Severe Hypertriglyceridemia

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

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