Novel Antioxidant Compounds from the Aqueous Extract of the Roots ofDecalepis hamiltonii(Wight and Arn.) and Their Inhibitory Effect on Low-Density Lipoprotein Oxidation

2006 ◽  
Vol 54 (3) ◽  
pp. 790-795 ◽  
Author(s):  
Anup Srivastava ◽  
R. Harish ◽  
T. Shivanandappa
Keyword(s):  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Inhibitory Effect ◽  
Antioxidant Compounds ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

scholarly journals Inhibitory Effect of Coumarins from Weigela subsessilis on Low Density Lipoprotein Oxidation

2005 ◽  
Vol 28 (6) ◽  
pp. 1095-1097 ◽  
Author(s):  
Phuong Thien Thuong ◽  
MinKyun Na ◽  
Nguyen Duy Su ◽  
Rack Seon Seong ◽  
Young Mi Lee ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Inhibitory Effect ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Weigela Subsessilis ◽  
Low Density Lipoprotein Oxidation

Protective effects of organic solvent fractions from the seeds of Vigna radiata L. wilczek against antioxidant mechanisms

2010 ◽  
Vol 30 (8) ◽  
pp. 904-909 ◽  
Author(s):  
Ill-Min Chung ◽  
Min-A Yeo ◽  
Sun-Jin Kim ◽  
Hyung-In Moon
Keyword(s):  
Organic Solvent ◽  
Mung Bean ◽  
Reactive Nitrogen Species ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Inhibitory Effect ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Low Density Lipoprotein Oxidation

This study was conducted to evaluate the in vitro scavenging activity and inhibitory effect of low-density lipoprotein oxidation of pro-oxidant reactive species in response to treatment with organic solvent fractions from mung bean (seeds of Vigna radiata) extracts using various screening methods including biological and non-biological oxidants. The antioxidant activity of different organic solvent fractions from mung bean extracts were studied in vitro methods by evaluating the total phenol components, measuring the antioxidant activity by trolox equivalent antioxidant capacity, measuring the scavenging effects on reactive oxygen species and on reactive nitrogen species as well as measuring the inhibitory effect on Cu2+-induced human low-density lipoprotein oxidation. The mung bean extracts were found to have a potent scavenging activity against all of the reactive species tested as well as an inhibitory effect on low-density lipoprotein oxidation, the studied mung bean was revealed to be very effective against the evaluated pro-oxidant species, including reactive oxygen species and on reactive nitrogen species.

scholarly journals Protective Effect of Lusianthridin on Hemin-Induced Low-Density Lipoprotein Oxidation

2021 ◽  
Vol 14 (6) ◽  
pp. 567
Author(s):  
Su Wutyi Thant ◽  
Noppawan Phumala Morales ◽  
Visarut Buranasudja ◽  
Boonchoo Sritularak ◽  
Rataya Luechapudiporn
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Raw 264.7 ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Raw 264.7 Macrophage Cells ◽  
Low Density Lipoprotein Oxidation

Oxidation of low-density lipoprotein (LDL) plays a crucial role in the pathogenesis of atherosclerosis. Hemin (iron (III)-protoporphyrin IX) is a degradation product of hemoglobin that can be found in thalassemia patients. Hemin is a strong oxidant that can cause LDL oxidation and contributes to atherosclerosis in thalassemia patients. Lusianthridin from Dendrobium venustrum is a phenolic compound that possesses antioxidant activity. Hence, lusianthridin could be a promising compound to be used against hemin-induced oxidative stress. The major goal of this study is to evaluate the protective effect of lusianthridin on hemin-induced low-density lipoprotein oxidation (he-oxLDL). Here, various concentrations of lusianthridin (0.25, 0.5, 1, and 2 µM) were preincubated with LDL for 30 min, then 5 µM of hemin was added to initiate the oxidation, and oxidative parameters were measured at various times of incubation (0, 1, 3, 6, 12, 24 h). Lipid peroxidation of LDL was measured by thiobarbituric reactive substance (TBARs) assay and relative electrophoretic mobility (REM). The lipid composition of LDL was analyzed by using reverse-phase HPLC. Foam cell formation with he-oxLDL in RAW 264.7 macrophage cells was detected by Oil Red O staining. The results indicated that lusianthridin could inhibit TBARs formation, decrease REM, decrease oxidized lipid products, as well as preserve the level of cholesteryl arachidonate and cholesteryl linoleate. Moreover, He-oxLDL incubated with lusianthridin for 24 h can reduce the foam cell formation in RAW 264.7 macrophage cells. Taken together, lusianthridin could be a potential agent to be used to prevent atherosclerosis in thalassemia patients.

Sign in / Sign up

Export Citation Format

Share Document