Leaching of Pesticides from Biobeds:  Effect of Biobed Depth and Water Loading

2004 ◽  
Vol 52 (20) ◽  
pp. 6217-6227 ◽  
Author(s):  
Paul Fogg ◽  
Alistair B. A. Boxall ◽  
Allan Walker ◽  
Andrew Jukes
Keyword(s):  
Water Loading

IOP Lowering Effects of Ocimum basilicum Seed Extract in Two Rabbit Models of Ocular Hypertension

2019 ◽  
Vol 4 (1) ◽  
pp. 39
Author(s):  
Renu Agarwal ◽  
SK Gupta ◽  
Sushma Srivastava ◽  
Rohit Saxena
Keyword(s):  
Ocular Hypertension ◽  
Antioxidant Properties ◽  
Ocimum Basilicum ◽  
Seed Extract ◽  
Water Loading ◽  
Antiglaucoma Medication ◽  
Lowering Effect ◽  
Significant Difference ◽  
The Mean ◽  
And Control

Introduction: Ocimum basilicum (OB), a herb known for its antihypertensive, anticholinesterase and antioxidant properties was investigated for possible intraocular pressure (IOP) lowering effects in rabbits with ocular hypertension (OHT). Methods: The IOP lowering effect of a single drop of OB extract (OBE) was evaluated in oculonormotensive rabbits using three concentrations (0.25, 0.5 and 1% w/v). The concentration showing maximum IOP reduction was further evaluated in rabbits with water-loading and steroid-induced OHT. Results: IOP lowering effect of OBE 0.5% in oculonormotensive rabbit eyes was significantly greater compared to OBE 0.25% (p<0.05) but was comparable (p>0.05) to OBE 1%. Therefore, 0.5% concentration was selected for further evaluation. Pretreatment with OBE (0.5%) caused significantly lower increase in IOP after water loading amounting to 23.39% above baseline as compared to 54.00% in control eye, 15 minutes post water loading. At 60 minutes, post water loading, mean IOP rise was 95.12% and 63.58% in control and test eyes, respectively. Significant difference between the mean IOP of two eyes persisted during the 2nd hr. In rabbits with steroid induced OHT, OBE 0.5% produced a mean IOP reduction of 24.73% at the end of first hr and the mean peak IOP reduction of 31.63% was observed at the end of 2 hr. A significant difference between the IOP of test and control eyes persisted from 1 to 6 hr. Conclusions: Ocimum basilicum seed extract showed significant IOP lowering effect in rabbits with water loading and steroid induced OHT, however, its utility as an effective antiglaucoma medication needs further investigations.

Dependence of Urinary Prostaglandin E2 Excretion on Urinary Volume Rather than Solute Handling or Segmental Nephron Function in Man

1984 ◽  
Vol 67 (4) ◽  
pp. 413-420 ◽  
Author(s):  
Sming Kaojarern ◽  
Polavat Chennavasin ◽  
Ann Burdette ◽  
William B. Campbell ◽  
D. Craig Brater
Keyword(s):  
Prostaglandin E2 ◽  
Sodium Excretion ◽  
Fluid Intake ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Urinary Flow ◽  
Urinary Volume ◽  
Water Loading ◽  
Wide Range ◽  
Ad Libitum

1. Eight normal subjects underwent water loading alone and water loading plus 40 mg of frusemide IV, fluid intake ad libitum alone and fluid intake ad libitum plus frusemide, plus each of the preceding after pretreatment with indomethacin. 2. After frusemide administration, increases in urinary sodium excretion paralleled increases in urinary volume, and urinary prostaglandin E2 (PGE2) excretion correlated closely with sodium excretion (y = 1.03x −0.28; r = 0.940; P<.0001). 3. In the absence of the diuretic, urinary volume varied over a wide range with little change in sodium excretion. Again, urinary PGE2 excretion correlated with urinary sodium excretion (y = 0.12x + 0.05; r = 0.789; P<.002). However, the correlation differed markedly from that observed in the studies with frusemide. 4. Expressing urinary PGE2 excretion as a function of urinary volume for all of the studies resulted in a highly significant correlation (y = 10.7x −0.70; r = 0.975; P<.0001). 5. Multiple and stepwise regression analyses assessing the correlation of urinary PGE2 excretion with urinary flow rate and with indices of function of various nephron segments indicate that the correlation with urinary PGE2 could be predominantly accounted for by urinary volume. 6. We conclude that in the condition of this study in man, urinary PGE2 excretion is a correlate of urinary volume.

Stimulation of glucagon-like peptide-1 secretion by water loading in human

2014 ◽  
Vol 459 (1) ◽  
pp. 323-325 ◽  
Author(s):  
A. S. Marina ◽  
A. V. Kutina ◽  
E. I. Shakhmatova ◽  
E. V. Balbotkina ◽  
Yu. V. Natochin
Keyword(s):  
Water Loading ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Stimulation Of

scholarly journals Catalytic Influence of Water Vapor on Lean Blowoff and NOx Reduction for Pressurised Swirling Syngas Flames

2017 ◽  
Author(s):  
Daniel Pugh ◽  
Philip Bowen ◽  
Andrew Crayford ◽  
Richard Marsh ◽  
Jon Runyon ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Reaction Rate ◽  
Catalytic Effect ◽  
Laminar Flame ◽  
Nox Reduction ◽  
Flame Temperature ◽  
Stability Limit ◽  
Flame Speed ◽  
Laminar Flame Speed ◽  
Water Loading

It has become increasingly cost-effective for the steel industry to invest in the capture of heavily carbonaceous BOF (Basic Oxygen Furnace) or converter gas, and use it to support the intensive energy demands of the integrated facility, or for surplus energy conversion in power plants. As industry strives for greater efficiency via ever more complex technologies, increased attention is being paid to investigate the complex behavior of by-product syngases. Recent studies have described and evidenced the enhancement of fundamental combustion parameters such as laminar flame speed due to the catalytic influence of H2O on heavily carbonaceous syngas mixtures. Direct formation of CO2 from CO is slow due to its high activation energy, and the presence of disassociated radical hydrogen facilitates chain branching species (such as OH), changing the dominant path for oxidation. The observed catalytic effect is non-monotonic, with the reduction in flame temperature eventually prevailing, and overall reaction rate quenched. The potential benefits of changes in water loading are explored in terms of delayed lean blowoff, and primary emission reduction in a premixed turbulent swirling flame, scaled for practical relevance at conditions of elevated temperature (423 K) and pressure (0.1–0.3 MPa). Chemical kinetic models are used initially to characterize the influence that H2O has on the burning characteristics of the fuel blend employed, modelling laminar flame speed and extinction strain rate across an experimental range with H2O vapor fraction increased to eventually diminish the catalytic effect. These modelled predictions are used as a foundation to investigate the experimental flame. OH* chemiluminescence and OH planar laser induced fluorescence (PLIF) are employed as optical diagnostic techniques to analyze changes in heat release structure resulting from the experimental variation in water loading. A comparison is made with a CH4/air flame and changes in lean blow off stability limits are quantified, measuring the incremental increase in air flow and again compared against chemical models. The compound benefit of CO and NOx reduction is quantified also, with production first decreasing due to the thermal effect of H2O addition from a reduction in flame temperature, coupled with the potential for further reduction from the change in lean stability limit. Power law correlations have been derived for change in pressure, and equivalent water loading. Hence, the catalytic effect of H2O on reaction pathways and reaction rate predicted and observed for laminar flames, are compared against the challenging environment of turbulent, swirl-stabilized flames at elevated temperature and pressure, characteristic of piratical systems.

scholarly journals Hydration Status Affects Nuclear Distribution of Transcription Factor Tonicity Responsive Enhancer Binding Protein in Rat Kidney

2001 ◽  
Vol 12 (11) ◽  
pp. 2221-2230 ◽  
Author(s):  
JUNG H. CHA ◽  
SEUNG KYOON WOO ◽  
KI H. HAN ◽  
YOUNG H. KIM ◽  
JOSEPH S. HANDLER ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Mrna Expression ◽  
Nuclear Localization ◽  
Binding Protein ◽  
Renal Medulla ◽  
Urine Osmolality ◽  
Hydration Status ◽  
Water Loading ◽  
Nuclear Distribution ◽  
Enhancer Binding Protein

Abstract. Tonicity responsive enhancer binding protein (TonEBP) is the transcription factor that regulates tonicity responsive expression of proteins that catalyze cellular accumulation of compatible osmolytes. In cultured MDCK cells, hypertonicity stimulates the activity of TonEBP via a combination of increased protein abundance and increased nuclear localization. For investigating regulation of TonEBP in the kidney, rats were subjected to water loading or dehydration. Water loading lowered urine osmolality and mRNA expression of sodium/myo-inositol cotransporter (SMIT), a target gene of TonEBP, in the renal medulla; dehydration doubled the urine osmolality and increased SMIT mRNA expression. In contrast, overall abundance of TonEBP and its mRNA measured by immunoblot and ribonuclease protection assay, respectively, was not affected. Immunohistochemical analysis, however, revealed that nuclear distribution of TonEBP is generally increased throughout the medulla in dehydrated animals compared with water loaded animals. Increased nuclear localization was particularly dramatic in thin limbs. Notable exceptions were the middle to terminal portions of the inner medullary collecting ducts and blood vessels, where a change in TonEBP distribution was not evident. Immunohistochemical detection of SMIT mRNA revealed that the changes in nuclear distribution of TonEBP correlate with expression of SMIT. It is concluded that under physiologic conditions, nucleocytoplasmic distribution is the dominant mode of regulation of TonEBP in the renal medulla.

scholarly journals Effects of Curcuma Longa and Galega Orientalis Herbal Remedies on Homeostatic Renal Functions in Rats with Diabetes Mellitus and Acute Renal Failure

2019 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Functional State ◽  
Curcuma Longa ◽  
Hypoglycemic Effect ◽  
Herbal Remedies ◽  
Water Loading ◽  
Renal Functions ◽  
Galega Orientalis

Aim: To study the effects of phytopreparations Curcuma longa and Galega orientalis on homeostatic renal functions in rats with diabetes mellitus (DM) and acute renal failure (ARF) models. Materials and methods: The experiments were performed in 2 series on male Wistar rats (n = 60) with a model of diabetes mellitus (the 1-st one) and acute renal failure (the 2-nd one). In both series, the animals were divided into 3 groups: rats of the 1-st group were kept on standard feed, the rats of the other groups were got additionally to the feed turmeric (the 2-nd group) or galega (the 3-d group) (2% of feed weight). On the 3-d day of the experiment, the study of diuretic and ionuretic renal functions on an empty stomach and after water loading was performed. The concentration of ions in urine and plasma was determined by flame photometry; osmotic concentration of biological fluids - by cryoscopy; blood biochemical parameters– by colorimetric method. Results: In diabetic against both at the background and following water loading polyuria compared to the control animals was observed. Intake of Curcuma longa resulted in a slight decrease of polyuria, but an increase in the Na+ and K+ concentration in the urine. It has been shown that turmeric and galega have a hypoglycemic effect and contribute to the normalization of plasma homeostatic parameters by improving the functional state of the kidneys. This effect was most pronounced following turmeric intake. In rats with acute renal failure both phytopreparations did not cause the changes in renal functions. Conclusion: Phytopreparations of turmeric and galega in diabetes have a hypoglycemic effect, contribute to the normalization of plasma homeostatic parameters and improve the functional state of the kidneys. In acute renal failure, these herbal remedies have almost no effect on osmotic and ion-regulating responses.

Lessons Learned From Freespans at Pipeline Watercourse Crossings

2020 ◽  
Author(s):  
Gerry Ferris
Keyword(s):  
Static Load ◽  
Water Velocity ◽  
Lessons Learned ◽  
Vortex Induced Vibration ◽  
Water Loading ◽  
Relevant Question ◽  
The Past ◽  
Load Limit ◽  
Pipeline Failure

Abstract Over the past 10 years inspections (site visits, boat based surveys or diver surveys) have been completed at nearly 20,000 pipeline watercourse crossings for 20 different pipeline owners. During the last 10 years there have been 721 unique locations where an exposed pipeline was found and at 213 of these locations a freespan was encountered. Only one of the freespans resulted in the failure (loss of product) of the pipeline. This record illustrates what is now become widely accepted, that pipeline exposure does not necessarily lead to pipeline failure. The record adds to this, pipeline freespan does not necessarily lead to failure. This highlights that the relevant question for “water loading caused pipeline failure” is: Does the combination of freespan length and water velocity exceed a combination that would lead to vortex induced vibration or the exceedance of the static load limit of the pipe?

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