Multiresidue Determination of Pesticides in Soil by Gas Chromatography−Mass Spectrometry Detection

2004 ◽  
Vol 52 (6) ◽  
pp. 1445-1451 ◽  
Author(s):  
Consuelo Sánchez-Brunete ◽  
Beatriz Albero ◽  
José L. Tadeo
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Mass Spectrometry Detection ◽  
Chromatography Mass Spectrometry ◽  
Multiresidue Determination

scholarly journals Multiresidue Determination of Zeranol and Related Compounds in Bovine Muscle by Gas Chromatography/Mass Spectrometry with Immunoaffinity Cleanup

2006 ◽  
Vol 89 (6) ◽  
pp. 1677-1681 ◽  
Author(s):  
Wei Zhang ◽  
Hejia Wang ◽  
Jianping Wang ◽  
Xiaowei Li ◽  
Haiyang Jiang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Bovine Muscle ◽  
Chromatography Mass Spectrometry ◽  
Coefficients Of Variation ◽  
Multiresidue Determination ◽  
Sepharose 4B ◽  
Related Compounds

Abstract A gas chromatography/mass spectrometry (GC/MS) method with immunoaffinity cleanup was developed for the determination of zeranol and related compounds, taleranol, zearalanone, and α-zearalenol in bovine muscle. Muscle samples were extracted with methanol and cleaned up with immunoaffinity chromatography (IAC) columns containing monoclonal antibodies raised against zeranol coupled to CNBr-activated Sepharose 4B. After derivatization, the compounds were analyzed by GC/MS. The dynamic column capacities for zeranol, taleranol, zearalanone, and α-zearalenol were 2639.7, 2840.3, 2731.5, and 2736.3 ng/mL Sepharose gel, respectively. The limits of detection and quantification were 0.5 and 1.0 ng/g, respectively, for all 4 compounds. Mean recoveries were 79.6110.7% with coefficients of variation of 3.211.4% at spiked levels of 1.05.0 ng/g. This IAC-GC/MS method may be used for the determination of zeranol, taleranol, zearalanone, and α-zearalenol residues in bovine muscle, and possibly other tissues.

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