Inhibitory Effect of Caffeic Acid Phenethyl Ester on Angiogenesis, Tumor Invasion, and Metastasis

2003 ◽  
Vol 51 (27) ◽  
pp. 7907-7912 ◽  
Author(s):  
Hui-Fen Liao ◽  
Yu-Ywan Chen ◽  
Jun-Jen Liu ◽  
Ming-Ling Hsu ◽  
Hui-Ju Shieh ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Tumor Invasion ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Invasion And Metastasis

Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells

2008 ◽  
Vol 128 (12) ◽  
pp. 1303-1307 ◽  
Author(s):  
Jae-Jun Song ◽  
Jae Gu Cho ◽  
Soon-Jae Hwang ◽  
Chang Gun Cho ◽  
Seok-Won Park ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Caffeic Acid ◽  
Middle Ear ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Human Middle Ear

scholarly journals Caffeic Acid Phenethyl Ester Inhibits UV-Induced MMP-1 Expression by Targeting Histone Acetyltransferases in Human Skin

2019 ◽  
Vol 20 (12) ◽  
pp. 3055 ◽  
Author(s):  
Eun Ju Shin ◽  
Seongin Jo ◽  
Hyo-kyoung Choi ◽  
Sungbin Choi ◽  
Sanguine Byun ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Human Skin ◽  
Ex Vivo ◽  
Bioactive Compound ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Dermal Fibroblasts ◽  
Regulatory Pathways ◽  
Skin Photoaging ◽  
Hdf Cells

Caffeic acid phenethyl ester (CAPE), a naturally occurring bioactive compound, displays anti-inflammatory, anti-carcinogenic, and anti-microbial effects. However, the effect of CAPE on skin photoaging is unknown. Herein, we investigated the inhibitory effect of CAPE against ultraviolet (UV) irradiation-mediated matrix metalloproteinase (MMP)-1 expression and its underlying molecular mechanism. CAPE treatment suppressed UV-induced MMP-1 levels in both human dermal fibroblasts (HDF) and human skin tissues. While CAPE did not display any significant effects against the upstream regulatory pathways of MMP-1, CAPE was capable of reversing UV-mediated epigenetic modifications. CAPE suppressed UV-induced acetyl-histone H3 (Lys9) as well as total lysine acetylation in HDF cells. Similarly, CAPE also attenuated UV-induced lysine acetylations in human skin tissues, suggesting that the CAPE-mediated epigenetic alterations can be recapitulated in ex vivo conditions. CAPE was found to attenuate UV-induced histone acetyltransferase (HAT) activity in HDF. Notably, CAPE was able to directly inhibit the activity of several HATs including p300, CREP-binding protein (CBP), and p300/CBP-associated factor (PCAF), further confirming that CAPE can function as an epigenetic modulator. Thus, our study suggests that CAPE maybe a promising agent for the prevention of skin photoaging via targeting HATs.

The inhibitory effect of propolis and caffeic acid phenethyl ester on cyclooxygenase activity in J774 macrophages

Phytomedicine ◽  
2002 ◽  
Vol 9 (6) ◽  
pp. 530-535 ◽  
Author(s):  
A. Rossi ◽  
A. Ligresti ◽  
R. Longo ◽  
A. Russo ◽  
F. Borrelli ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Cyclooxygenase Activity

Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats

2004 ◽  
Vol 339 (1-2) ◽  
pp. 65-75 ◽  
Author(s):  
Hüseyin Özyurt ◽  
Sadık Söğüt ◽  
Zeki Yıldırım ◽  
Levent Kart ◽  
Mustafa Iraz ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Lung Fibrosis ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect

scholarly journals Antibacterial Effect of Caffeic Acid Phenethyl Ester on Cariogenic Bacteria and Streptococcus mutans Biofilms

2020 ◽  
Vol 64 (9) ◽  
Author(s):  
Yumei Niu ◽  
Kun Wang ◽  
Sainan Zheng ◽  
Yufei Wang ◽  
Qian Ren ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Streptococcus Mutans ◽  
Acid Tolerance ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
Extracellular Polysaccharides ◽  
Common Disease ◽  
Streptococcus Sobrinus ◽  
Content Type ◽  
Cariogenic Bacteria

ABSTRACT Dental caries is the most common disease in the human mouth. Streptococcus mutans is the primary cariogenic bacterium. Propolis is a nontoxic natural product with a strong inhibitory effect on oral cariogenic bacteria. The polyphenol-rich extract from propolis inhibits S. mutans growth and biofilm formation, as well as the genes involved in virulence and adherence, through the inhibition of glucosyltransferases (GTF). However, because the chemical composition of propolis is highly variable and complex, the mechanism of its antimicrobial action and the active compound are controversial and not completely understood. Caffeic acid phenethyl ester (CAPE) is abundant in the polyphenolic compounds from propolis, and it has many pharmacological effects. In this study, we investigated the antibacterial effects of CAPE on common oral cariogenic bacteria (Streptococcus mutans, Streptococcus sobrinus, Actinomyces viscosus, and Lactobacillus acidophilus) and its effects on the biofilm-forming and cariogenic abilities of S. mutans. CAPE shows remarkable antimicrobial activity against cariogenic bacteria. Moreover, CAPE also inhibits the formation of S. mutans biofilms and their metabolic activity in mature biofilms. Furthermore, CAPE can inhibit the key virulence factors of S. mutans associated with cariogenicity, including acid production, acid tolerance, and the bacterium’s ability to produce extracellular polysaccharides (EPS), without affecting bacterial viability at subinhibitory levels. In conclusion, CAPE appears to be a new agent with anticariogenic potential, not only via inhibition of the growth of cariogenic bacteria.

Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo

2006 ◽  
Vol 234 (2) ◽  
pp. 199-208 ◽  
Author(s):  
Hsing-Chun Kuo ◽  
Wu-Hsien Kuo ◽  
Yean-Jang Lee ◽  
Wea-Lung Lin ◽  
Fen-Pi Chou ◽  
...  
Keyword(s):  
Caffeic Acid ◽  
Glioma Cells ◽  
Caffeic Acid Phenethyl Ester ◽  
Inhibitory Effect ◽  
C6 Glioma ◽  
C6 Glioma Cells
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