Enhanced Expression of Chicken Cystatin as a Thioredoxin Fusion Form inEscherichia coliAD494(DE3)pLysS and Its Effect on the Prevention of Surimi Gel Softening

2002 ◽  
Vol 50 (13) ◽  
pp. 3731-3737 ◽  
Author(s):  
Shann-Tzong Jiang ◽  
Shinn-Shuenn Tzeng ◽  
Wun-Tsai Wu ◽  
Gen-Hung Chen
Keyword(s):  
Surimi Gel ◽  
Enhanced Expression ◽  
Chicken Cystatin

Enhanced expression of TGFβ, collagen, and TIMP-1 genes in esophageal stricture

2001 ◽  
Vol 120 (5) ◽  
pp. A153-A153
Author(s):  
M KLINE ◽  
Z ZANG ◽  
K PATEL ◽  
S FRENCH ◽  
H TSUKAMOTO
Keyword(s):  
Esophageal Stricture ◽  
Enhanced Expression

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Enhanced expression of the transcriptional activators YAP and TAZ in non-secreting pituitary tumours

2018 ◽  
Author(s):  
Paraskevi Xekouki ◽  
Emily Lodge ◽  
Ran Li ◽  
Jorg Flitsch ◽  
Stefan Bornstein ◽  
...  
Keyword(s):  
Transcriptional Activators ◽  
Pituitary Tumours ◽  
Enhanced Expression

Enhanced Expression of Fibroblast Growth Factor Receptor 3 in Human Skin Cancer Cells

2009 ◽  
Vol 2 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Motoki Terada ◽  
Chikara Ohnishi ◽  
Nobuhiro Ueno ◽  
Akio Shimizu ◽  
Michiyuki Kanai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Skin Cancer ◽  
Cancer Cells ◽  
Fibroblast Growth Factor ◽  
Human Skin ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Fibroblast Growth ◽  
Enhanced Expression

scholarly journals Dysregulated liver lipid metabolism and innate immunity associated with hepatic steatosis in neonatal BBdp rats and NOD mice

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
D. Serrano ◽  
J. A. Crookshank ◽  
B. S. Morgan ◽  
R. W. Mueller ◽  
M.-F. Paré ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Lipid Metabolism ◽  
Hepatic Steatosis ◽  
Liver Lipid ◽  
Nod Mice ◽  
Gene Signature ◽  
Enhanced Expression ◽  
Liver Lipid Metabolism ◽  
Hepatic Innate Immunity ◽  
Lipid Metabolism Genes

Abstract In a previous study we reported that prediabetic rats have a unique gene signature that was apparent even in neonates. Several of the changes we observed, including enhanced expression of pro-inflammatory genes and dysregulated UPR and metabolism genes were first observed in the liver followed by the pancreas. In the present study we investigated further early changes in hepatic innate immunity and metabolism in two models of type 1 diabetes (T1D), the BBdp rat and NOD mouse. There was a striking increase in lipid deposits in liver, particularly in neonatal BBdp rats, with a less striking but significant increase in neonatal NOD mice in association with dysregulated expression of lipid metabolism genes. This was associated with a decreased number of extramedullary hematopoietic clusters as well as CD68+ macrophages in the liver of both models. In addition, PPARɣ and phosphorylated AMPKα protein were decreased in neonatal BBdp rats. BBdp rats displayed decreased expression of antimicrobial genes in neonates and decreased M2 genes at 30 days. This suggests hepatic steatosis could be a common early feature in development of T1D that impacts metabolic homeostasis and tolerogenic phenotype in the prediabetic liver.

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