His-His-Leu, an Angiotensin I Converting Enzyme Inhibitory Peptide Derived from Korean Soybean Paste, Exerts Antihypertensive Activity in Vivo

2001 ◽  
Vol 49 (6) ◽  
pp. 3004-3009 ◽  
Author(s):  
Zae-Ik Shin ◽  
Rina Yu ◽  
Soo-Ah Park ◽  
Dae Kyun Chung ◽  
Chang-Won Ahn ◽  
...  
Keyword(s):  
Antihypertensive Activity ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Inhibitory Peptide ◽  
Angiotensin I Converting Enzyme ◽  
Soybean Paste

scholarly journals Angiotensin I-Converting Enzyme (ACE) Inhibitory Activity of Peptides Isolated from Carabao Mango (Mangifera indica) Flesh

KIMIKA ◽  
2021 ◽  
Vol 32 (1) ◽  
pp. 1-18
Author(s):  
Trisha Rojas ◽  
Jherome Co ◽  
Mia Clare Marie Bercansil ◽  
Lory Jane Dela Cruz ◽  
Lawrence Yves Uy ◽  
...  
Keyword(s):  
Mangifera Indica ◽  
Ace Inhibition ◽  
The Philippines ◽  
Antihypertensive Activity ◽  
Converting Enzyme ◽  
Angiotensin I ◽  
Inhibitory Peptide ◽  
Angiotensin I Converting Enzyme ◽  
Ace Inhibitory

Hypertension has been reported as the second major cause of morbidity in the Philippines. One of the mechanisms to control blood pressure is through the inhibition of the angiotensin I-converting enzyme (ACE). This study specifically focused on the determination of ACE inhibitory activities of peptides from ‘Carabao’ mango flesh of three shell colors (SC1, SC3, SC5). The bioactive peptides were obtained upon a series of extraction, purification, and enzymatic hydrolysis steps. Among the undigested and digested crude and purified samples, the highest in vitro ACE inhibition was exhibited by the three-hour digest of SC3 (83.28 ± 0.83%). The most prominent peak from the fractionation of the mixture of peptides in SC3 digest was evaluated for ACE inhibition, and the decrease in activity inferred the synergistic effect of the peptides in exhibiting the inhibitory function. This selected bioactive peptide was revealed to have alanine and phenylalanine as the components, which can possibly be AF – an ACE inhibitory peptide determined from in silico analyses. Meanwhile, assessment of the in vivo antihypertensive activity showed no significant results due to insufficiently administered doses of the samples. Overall, the measured activity of the ACE inhibitory peptides inferred the potential of mango as a functional food in dealing with hypertension.  

scholarly journals Separation and Purification of Angiotensin I Converting Enzyme Inhibitory Peptide in Peptic Hydrolyzate of Oyster.

1994 ◽  
Vol 41 (9) ◽  
pp. 589-594 ◽  
Author(s):  
Kiyoshi MATSUMOTO ◽  
Atsuko OGIKUBO ◽  
Takatada YOSHINO ◽  
Toshiro MATSUI ◽  
Yutaka OSAJIMA
Keyword(s):  
Converting Enzyme ◽  
Separation And Purification ◽  
Angiotensin I ◽  
Inhibitory Peptide ◽  
Angiotensin I Converting Enzyme

Evaluation and Identification of Potent Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Dwarf Gulper Shark (C entrophorus atromarginatus )

2014 ◽  
Vol 39 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Asami Ikeda ◽  
Hayato Ichino ◽  
Saori Kiguchiya ◽  
Petros Chigwechokha ◽  
Masaharu Komatsu ◽  
...  
Keyword(s):  
Converting Enzyme ◽  
Angiotensin I ◽  
Inhibitory Peptide ◽  
Angiotensin I Converting Enzyme
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