Antimicrobial activity of the volatile constituents of Perilla frutescens and its synergistic effects with polygodial

1992 ◽  
Vol 40 (11) ◽  
pp. 2328-2330 ◽  
Author(s):  
Raphael. Kang ◽  
Randi. Helms ◽  
Michael J. Stout ◽  
Hasan. Jaber ◽  
Zhengqing. Chen ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Synergistic Effects ◽  
Perilla Frutescens ◽  
Volatile Constituents

scholarly journals Development of Novel Thin Polycaprolactone (PCL)/Clay Nanocomposite Films with Antimicrobial Activity Promoted by the Study of Mechanical, Thermal, and Surface Properties

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3193
Author(s):  
Sylva Holešová ◽  
Karla Čech Čech Barabaszová ◽  
Marianna Hundáková ◽  
Michaela Ščuková ◽  
Kamila Hrabovská ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Surface Properties ◽  
Food Packaging ◽  
Synergistic Effects ◽  
Nanocomposite Films ◽  
Mechanical Resistance ◽  
X Ray Diffraction ◽  
Microbial Strains ◽  
And Storage ◽  
Structure Properties

Infection with pathogenic microorganisms is of great concern in many areas, especially in healthcare, but also in food packaging and storage, or in water purification systems. Antimicrobial polymer nanocomposites have gained great popularity in these areas. Therefore, this study focused on new approaches to develop thin antimicrobial films based on biodegradable polycaprolactone (PCL) with clay mineral natural vermiculite as a carrier for antimicrobial compounds, where the active organic antimicrobial component is antifungal ciclopirox olamine (CPX). For possible synergistic effects, a sample in combination with the inorganic antimicrobial active ingredient zinc oxide was also prepared. The structures of all the prepared samples were studied by X-ray diffraction, FTIR analysis and, predominantly, by SEM. The very different structure properties of the prepared nanofillers had a fundamental influence on the final structural arrangement of thin PCL nanocomposite films as well as on their mechanical, thermal, and surface properties. As sample PCL/ZnOVER_CPX possessed the best results for antimicrobial activity against examined microbial strains, the synergic effect of CPX and ZnO combination on antimicrobial activity was proved, but on the other hand, its mechanical resistance was the lowest.

Synergistic Effects of Essential Oils of Ammoides verticillata and Satureja candidissima Against Many Pathogenic Microorganisms

2020 ◽  
Vol 18 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Fatima Benyoucef ◽  
Mohammed El Amine Dib ◽  
Boufeldja Tabti ◽  
Arrar Zoheir ◽  
Jean Costa ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Synergistic Effects ◽  
Lactobacillus Rhamnosus ◽  
Salmonella Typhi ◽  
Antimicrobial Activities ◽  
Bacterial Strains ◽  
Gram Negative ◽  
Ammoides Verticillata

Background: Antibiotic resistance is today one of the most serious threats to global health, food security and development. Due to the growing number of infections, treatment becomes more difficult, if not impossible, because of the loss of antibiotic efficacy. Objective: In the present investigation, the chemical composition of essential oils of Ammoides verticillata and Satureja candidissima and their synergistic effects on antimicrobial activities were investigated. Methods: The chemical composition of the essential oil was analyzed by Gas Chromatography (GC) and Gas Chromatography-Mass Spectroscopy (GC/MS). The antimicrobial activity of the essential oils was investigated using dilution-agar method against nine bacterial strains three Gram-negative Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Salmonella typhi (ATCC 14028), and six Gram-positive: Staphylococcus aureus (ATCC 43300,) Clostridium sporogenes (ATCC 19404), Bacillus subtilis (ATCC 6633), Enterococcus faecalis (ATCC 7314), Lactobacillus rhamnosus (ATCC 53103) and Bacillus cereus (ATCC 14579). Results: The essential oil of A. verticillata was characterized principally by carvacrol (44,3%), Limonene (19,3%) and p-cymene (19,2%). The constituents identified of S. candidissima essential oil were principally oxygenated monoterpenes represented by pulegone (70,4%). The essential oil of A. verticillata had a good antimicrobial activity against four bacterial strains (Escherichia coli, Salmonella typhi, Lactobacillus rhamnosus and Bacillus cereus) with MIC and MBC values between 0.2-0.4 µl/ml and 0.2-6.2 µl/ml, respectively. While, S. candidissima essential oil had moderate antimicrobial activities against all strains with MIC and MBC values between 1.5-6.2 µl/ml and 6.2-12.5 µl/ml, respectively. The results of antimicrobial activity of essential oils blend presented higher antimicrobial activity against all tested bacteria with MIC and MBC values between 0.3-1.5 µl/ml and 0.4-6.2 µl/ml, respectively. Conclusion: The essential oils blend presented high antimicrobial activity compared to virgin oils. This activity can be due to the association of active compounds such as carvacrol and pulegone. These findings provide a new source of drugs that may help in therapy to lead to the development of a new treatment based on a combination of these essential oils against gram-negative and gram-positive bacteria that continue to pose a threat to public health.

ANTIMICROBIAL ACTIVITY OF COPPER KAOLINITE AND SURFACTANT MODIFIED COPPER KAOLINITE AGAINST GRAM POSITIVE AND GRAM NEGATIVE BACTERIA

2016 ◽  
Vol 78 (3-2) ◽  
Author(s):  
Nor Syafawani Sarah Md Saad ◽  
Nik Ahmad Nizam Nik Malek ◽  
Chun Shiong Chong
Keyword(s):  
Antimicrobial Activity ◽  
Synergistic Effects ◽  
Wide Spectrum ◽  
Copper Nitrate ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
X Ray ◽  
Gram Positive Bacteria ◽  
Diffusion Technique

The aim of this research was to determine the antimicrobial activity of kaolinite modified with antimicrobial compounds against Gram positive and Gram negative bacteria. Copper kaolinite (Cu-kaolinite) was prepared by loading raw kaolinite with copper nitrate trihydrate (CuNO3) while surfactant modified Cu-kaolinite (SM-Cu-kaolinite) was prepared by adding cationic surfactants hexadecyltrimethyl ammonium (HDTMA) on Cu-Kaolinite. Samples was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analyzer. The antimicrobial activity of the samples was tested against Gram negative bacteria (Escherichia coli ATCC 11229 and Pseudomonas aeruginosa ATCC 15442), and Gram positive bacteria (Staphylococcus aureus ATCC 6538 and Enterococcus faecalis ATCC 29212) through disc diffusion technique (DDT) and minimum inhibition concentration (MIC). The results showed that the antimicrobial activity of Cu-kaolinite increased after modified with HDTMA due to the synergistic effects of Cu ions and HDTMA molecules on the kaolinite. The antimicrobial activity for surfactant modified Cu-kaolinite was greater for Gram positive bacteria compared to Gram negative bacteria. In conclusion, the attachment of HDTMA on Cu-kaolinite contributed to the enhanced antimicrobial activity against wide spectrum of bacteria (Gram positive and Gram negative bacteria).

Synergistic effects of chitosan–guanidine complexes on enhancing antimicrobial activity and wet-strength of paper

2010 ◽  
Vol 101 (14) ◽  
pp. 5693-5700 ◽  
Author(s):  
Shengling Sun ◽  
Qiaozhi An ◽  
Xu Li ◽  
Liying Qian ◽  
Beihai He ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Synergistic Effects ◽  
Wet Strength

Synthesis, structural analysis, antimicrobial evaluation and synergistic studies of imidazo[1,2-a]pyrimidine chalcogenides

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114224-114234 ◽  
Author(s):  
Nidhi Sharma ◽  
Sanjeev Kumar ◽  
Indresh K. Maurya ◽  
K. K. Bhasin ◽  
Ajay Verma ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Structural Analysis ◽  
Synergistic Effects ◽  
Antimicrobial Evaluation

Synthesis and structural analysis of novel imidazo[1,2-a]pyrimidine chalcogenides exhibiting effective antimicrobial activity and synergistic effects with known antibiotics have been reported.

scholarly journals CHITOSAN NANOPARTICLES AS DRUG DELIVERY SYSTEM FOR CEPHALEXIN AND ITS ANTIMICROBIAL ACTIVITY AGAINST MULTIIDRUG RESISTENT BACTERIA

2019 ◽  
pp. 14-27 ◽  
Author(s):  
Mona Elassal ◽  
Nagwan El-Manofy
Keyword(s):  
Antimicrobial Activity ◽  
Electron Microscope ◽  
Mammalian Cells ◽  
Synergistic Effects ◽  
Drug Loading ◽  
Chitosan Nanoparticles ◽  
Clinical Isolates ◽  
Antibiofilm Activity ◽  
Diffusion Kinetic

Objective: The evolution of antimicrobial resistance is a universal obstacle that necessities the innovation of more effective and safe antimicrobial alternatives with synergistic properties. The purpose of this study was to investigate the possible improvement of cephalexin antimicrobial treatments by loading into chitosan-based nanoparticles, then evaluate their antibacterial and antibiofilm activities as well as determination of its cytotoxicity. Methods: Chitosan nanoparticles (CSNPs) were prepared by ionic gelation method. Parameters were studied to optimize the particle size of CSNPs including pH, stirring rate, homogenization and ultra-sonication time. Size was measured by transmission electron microscope (TEM) and Zeta sizer, morphology seen by scanning electron microscope (SEM). Entrapment efficiency, drug loading and drug content were calculated. Stability of both plain and loaded chitosan Nano-carriers, Drug release and Kinetics also compatibilities were studied. Antimicrobial activity of CSNPs and cephalexin loaded CSNPs were evaluated against 4 Gram-positive and 4 Gram-negative standard and clinical isolates by microdilution method, also assessment of antibiofilm activity of both formulas was investigated against two biofilm producers clinical isolates by tube assay in addition to determination of their cytotoxicity by MTT(3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Results: Chitosan nanoparticles and its loaded antibiotics proved compatible combination with small Zeta size, suitable Zeta potential, maximum EE% and drug-loading capacity, sustained controlled release properties followed diffusion kinetic model and six month stability studies. Cephalexin loaded CSNPs showed better antimicrobial activity than plain CSNPs. Synergistic effects were found against S. aureus (ATCC 25923), B. subtilis (ATCC 9372), S. epidermidis, E. faecalis, P. aeruginosa (ATCC 29853) in addition to two carbapenem resistant isolates k. pneumoniae and E. coli. Also cephalexin loaded CSNPs exhibited antibiofilm activity against E. faecalis clinical isolate. Even though, cephalexin loaded CSNPs exhibited significant antibacterial activity, it showed less toxicity against mammalian cells, it had IC50 equal to 231.893 and did not exhibit any cytotoxicity against the WI-38 fibroblast cells at concentration 23.4 µg/ml. Conclusion: Cephalexin loaded CSNPs possessed good stability and sustained release effect in addition to its antimicrobial, antibiofilm activities and reduced cytotoxicity.

Phytotoxic and antimicrobial activity of volatile constituents ofArtemisia princeps var.orientalis

1993 ◽  
Vol 19 (11) ◽  
pp. 2757-2766 ◽  
Author(s):  
Kyeong Won Yun ◽  
Bong -Seop Kil ◽  
Dong Min Han
Keyword(s):  
Antimicrobial Activity ◽  
Volatile Constituents

Volatile constituents of propolis from various regions of Greece – Antimicrobial activity

2007 ◽  
Vol 103 (2) ◽  
pp. 375-380 ◽  
Author(s):  
Eleni Melliou ◽  
Eleftherios Stratis ◽  
Ioanna Chinou
Keyword(s):  
Antimicrobial Activity ◽  
Volatile Constituents ◽  
Of Greece
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