Amphiphilic Drug Promethazine Hydrochloride−Additive Systems: Evaluation of Thermodynamic Parameters at Cloud Point†

2010 ◽  
Vol 55 (5) ◽  
pp. 1893-1896 ◽  
Author(s):  
Md. Sayem Alam ◽  
Kabir-ud-Din ◽  
Asit Baran Mandal
Keyword(s):  
Thermodynamic Parameters ◽  
Cloud Point ◽  
Amphiphilic Drug ◽  
Promethazine Hydrochloride

Clouding behavior of antidepressant drug–additive system in ethylene glycol/glycerol–water mixed media and their thermodynamic parameters at cloud point

2018 ◽  
Vol 42 (6) ◽  
pp. 4402-4411 ◽  
Author(s):  
Ajmal Koya Pulikkal ◽  
Jackson Gurung
Keyword(s):  
Ethylene Glycol ◽  
Thermodynamic Parameters ◽  
Cloud Point ◽  
Antidepressant Drug ◽  
Mixed Media ◽  
Inorganic Salts ◽  
Glycerol Water ◽  
Additive System ◽  
Amphiphilic Drug ◽  
Amitriptyline Hydrochloride

The influence of ethylene glycol (EG)/glycerol(GL)–water mixed media on clouding action of an amphiphilic drug, amitriptyline hydrochloride was studied in presence and absence of inorganic salts in selected compositions of EG–WR and GL–WR mixed media.

Surfactants and ureas affect the cloud point of amphiphilic drug, clomipramine hydrochloride

2010 ◽  
Vol 81 (1) ◽  
pp. 152-157 ◽  
Author(s):  
Andleeb Z. Naqvi ◽  
Mohammed D.A. Al-Ahmadi ◽  
Mohd. Akram ◽  
Kabir-ud-Din
Keyword(s):  
Cloud Point ◽  
Amphiphilic Drug

CLOUD POINT AND DYE SOLUBILIZATION STUDIES OF AMPHIPHILIC DRUG SOLUTIONS: THE EFFECT OF ELECTROLYTES AND NONELECTROLYTES

2006 ◽  
Vol 193 (9) ◽  
pp. 1065-1074 ◽  
Author(s):  
Eui Jung Kim ◽  
Sunwook Kim ◽  
Ik-Keun Yoo ◽  
Jin Suk Chung ◽  
Jae Seong Kim ◽  
...  
Keyword(s):  
Cloud Point ◽  
Amphiphilic Drug ◽  
Dye Solubilization

scholarly journals Salt Effect on the Cloud Point Phenomenon of Amphiphilic Drug-Hydroxypropylmethyl Cellulose System

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mohd. Sajid Ali ◽  
Dileep Kumar ◽  
Hamad A. Al-Lohedan
Keyword(s):  
Cloud Point ◽  
Sodium Salt ◽  
Salt Effect ◽  
Tricyclic Antidepressant ◽  
High Concentration ◽  
Hydroxypropylmethyl Cellulose ◽  
Amphiphilic Drug ◽  
Amphiphilic Drugs ◽  
Nortriptyline Hydrochloride

Effect of two amphiphilic drugs (tricyclic antidepressant, nortriptyline hydrochloride (NORT), and nonsteroidal anti-inflammatory drug, sodium salt of ibuprofen (IBF)) on the cloud point of biopolymer hydroxypropylmethyl cellulose (HPMC) was studied. Effect of NaCl was also seen on the CP of HPMC-drug system. CP of HPMC increases uniformly on increasing the (drug). Both drugs, though one being anionic (IBF) and other cationic (NORT), affect the CP in almost the same manner but with different extent implying the role of hydrophobicity in the interaction between drug and polymer. Salt affects the CP of the drug in a dramatic way as low concentration of salt was only able to increase the value of the CP, though not affecting the pattern. However, in presence of high concentration of salts, minimum was observed on CP versus (drug) plots. Various thermodynamic parameters were evaluated and discussed on the basis of the observed results.

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