Apparent Molal Volumes and ViscosityB-Coefficients of Acetyl Salicylic Acid (2-Acetoxy Benzoic Acid) Solutions in Higher Alcohols at Different Temperatures

2010 ◽  
Vol 55 (12) ◽  
pp. 5921-5926 ◽  
Author(s):  
Muhammad J. Iqbal ◽  
Mansoora A. Chaudhry
1969 ◽  
Vol 47 (24) ◽  
pp. 4639-4643 ◽  
Author(s):  
J. E. Desnoyers ◽  
F. M. Ichhaporia

The solubility of toluene and benzaldehyde was measured in NaBr and (n-Pr)4NBr aqueous solutions at 25 °C, and the solubility of benzoic acid and nitrobenzene was measured in the same systems at 10, 25, and 40 °C. The apparent molal volumes of the four nonelectrolytes were also determined from the densities of the saturated aqueous solutions.The volumes of mixing of the nonelectrolytes in water are all negative but become less so as their polarity increases. With the exception of benzoic acid, the salting-out by NaBr and the salting-in by (n-Pr)4NBr both decrease with increasing polarity of the nonelectrolytes. Both salting effects increase with temperature. These trends can be explained with existing theories of salting-out and salting-in.


2017 ◽  
Vol 17 (1) ◽  
pp. 47
Author(s):  
Wahyu Dewi Tamayanti ◽  
Ratna Megawati Widharna ◽  
Catherine Caroline ◽  
Bambang Soekarjo

The new compounds of salicylic acid derivatives, 2- (3- (chloromethyl) benzoiloksi)benzoic acid and 2-(4-(chloromethyl)benzoiloksi) benzoate was synthesized to produce a greater analgesic activity and lower stomach irritation from salicylic acid. 2-(4-(chloromethyl) benzoiloksi)benzoic acid and 2-(3-(chloromethyl)benzoiloksi) benzoate was synthesized by Schotten-Baumann acylation reaction. In this study, the analgesic test activity with plantar test method. The compound was given to test animals in doses of 12.5; 25; 50; 100; and 200 mg.kg-1. Analgesic activity was determined by the response time of mice to pain infra-red heat. The percentage is calculated by the mean pain barrier time response to pain. The results showed percentation of pain barrier: 74.28%; 105.58%; 110.58%; 115.29%; and 175.87% after administration of the compound 2-(4-(chloromethyl) benzoiloksi) benzoate at doses of 12.5; 25; 50; 100; and 200 mg.kg-1, respectively. The results of calculations percent pain barrier 2-(3-(chloromethyl)benzoiloksi) benzoate, obtained 85.30%; 92.48%; 124.96%; 180.36%; and 208.01% consecutive for the doses compound of 12.5; 25; 50; 100; and 200 mg.kg-1. Five doses of acetyl salicylic acid ranging from 12.5 mg. kg-1 to 200 mg.kg-1 resulted in percent pain barrier as follows: 26%; 34.34%; 45.68%; 60.38% and 114.12%. This study indicates that 2-(3-(chloromethyl)benzoiloksi)benzoic acid and 2-(4-(chloromethyl)benzoiloksi) benzoate are capable of producing higher analgesic activity than acetyl salicylic acid. Keywords: analgesic, benzoate, plantar test method 


1967 ◽  
Vol 71 (10) ◽  
pp. 3242-3244
Author(s):  
Ronald A. Munson ◽  
Michael E. Lazarus

2001 ◽  
Vol 125 (1) ◽  
pp. 318-328 ◽  
Author(s):  
Julie Chong ◽  
Marie-Agnès Pierrel ◽  
Rossitza Atanassova ◽  
Danièle Werck-Reichhart ◽  
Bernard Fritig ◽  
...  

1987 ◽  
Vol 48 (4) ◽  
pp. 501-504 ◽  
Author(s):  
C. Doutremepuich ◽  
D. Pailley ◽  
M.C. Anne ◽  
O. de Séze ◽  
J. Paccalin ◽  
...  

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