Molecular Design of Brush-like Amphiphilic Statistical Tripolymers and Their Self-Assembly Behaviors

2013 ◽  
Vol 58 (4) ◽  
pp. 927-931 ◽  
Author(s):  
Xu Wu ◽  
Xiaoxin Cai ◽  
Ahui Hao ◽  
Jinben Wang
Keyword(s):  
Self Assembly ◽  
Molecular Design

Self-assembly of chiral oligo(methylene-p-phenylene-ethynylene)s into vesicle-like particles independent of hydrophobicity/hydrophilicity of side chains and solvents

Soft Matter ◽  
2021 ◽  
Author(s):  
Zhiqiang Zhao ◽  
Zheng Bian ◽  
Yu Chen ◽  
Chuanqing Kang ◽  
Lianxun Gao ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Design ◽  
The Self ◽  
Side Chains ◽  
Phenylene Ethynylene

Chiral oligo(methylene-p-phenyleneethynylene)s can form vesicular assemblies no matter whether side chains and solvents are hydrophilic or hydrophobic. The self-assembly processes are highly independent of molecular design and chemical environments.

scholarly journals The interfacial structure and Young's modulus of peptide films having switchable mechanical properties

2007 ◽  
Vol 5 (18) ◽  
pp. 47-54 ◽  
Author(s):  
A.P.J Middelberg ◽  
L He ◽  
A.F Dexter ◽  
H.-H Shen ◽  
S.A Holt ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Young’S Modulus ◽  
Self Assembly ◽  
Molecular Design ◽  
Foam Stability ◽  
Young's Modulus ◽  
Interfacial Structure ◽  
Water Interface ◽  
Air Water Interface ◽  
Peptide Dissociation

We report the structure and Young's modulus of switchable films formed by peptide self-assembly at the air–water interface. Peptide surfactant AM1 forms an interfacial film that can be switched, reversibly, from a high- to low-elasticity state, with rapid loss of emulsion and foam stability. Using neutron reflectometry, we find that the AM1 film comprises a thin (approx. 15 Å) layer of ordered peptide in both states, confirming that it is possible to drastically alter the mechanical properties of an interfacial ensemble without significantly altering its concentration or macromolecular organization. We also report the first experimentally determined Young's modulus of a peptide film self-assembled at the air–water interface ( E =80 MPa for AM1, switching to E <20 MPa). These findings suggest a fundamental link between E and the macroscopic stability of peptide-containing foam. Finally, we report studies of a designed peptide surfactant, Lac21E, which we find forms a stronger switchable film than AM1 ( E =335 MPa switching to E <4 MPa). In contrast to AM1, Lac21E switching is caused by peptide dissociation from the interface (i.e. by self-disassembly). This research confirms that small changes in molecular design can lead to similar macroscopic behaviour via surprisingly different mechanisms.

Hydrogen-bonded azaphenacene: a strategy for the organization of π-conjugated materials

2018 ◽  
Vol 6 (15) ◽  
pp. 3968-3975 ◽  
Author(s):  
Paula Gómez ◽  
Stamatis Georgakopoulos ◽  
José Pedro Cerón ◽  
Iván da Silva ◽  
Miriam Más-Montoya ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Design ◽  
The Self ◽  
Molecular Materials ◽  
Conjugated Materials ◽  
Hydrogen Bonded

Molecular design for the self-assembly of molecular materials.

Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

2020 ◽  
Vol 8 (31) ◽  
pp. 6739-6752
Author(s):  
Kaiqi Long ◽  
Yuwei Liu ◽  
Yafei Li ◽  
Weiping Wang
Keyword(s):  
Self Assembly ◽  
Biomedical Applications ◽  
Molecular Design ◽  
Structural Characteristics ◽  
Building Blocks

This review introduces trigonal building blocks and summarizes their structural characteristics, self-assembly ability and biomedical applications.

scholarly journals Surfactant-like peptides: From molecular design to controllable self-assembly with applications

2020 ◽  
Vol 421 ◽  
pp. 213418
Author(s):  
Jie Li ◽  
Jiqian Wang ◽  
Yurong Zhao ◽  
Peng Zhou ◽  
Jessica Carter ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Design

scholarly journals Self-assembly behaviours of peptide–drug conjugates: influence of multiple factors on aggregate morphology and potential self-assembly mechanism

2018 ◽  
Vol 5 (4) ◽  
pp. 172040 ◽  
Author(s):  
Qin Fan ◽  
Yujie Ji ◽  
Jingjing Wang ◽  
Li Wu ◽  
Weidong Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Design ◽  
Peptide Drug ◽  
Extrinsic Factors ◽  
Aromatic Fragment ◽  
Multiple Factors ◽  
Drug Conjugates ◽  
Assembly Mechanism ◽  
Aggregate Morphology ◽  
Peptide Drug Conjugates

Peptide–drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug ( S )-ketoprofen (Ket) and valine–glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour. Our results showed that the critical assembly concentration of Ket-L-VEVE was 0.32 mM in water to form various nanostructures which experienced from micelle, nanorod, nanofibre to nanoribbon. The morphology was influenced by multiple factors including molecular design, assembly time, pH and hydrogen bond inhibitor. On the basis of experimental results, we speculated the possible assembly mechanism of Ket-L-VEVE. The π–π stacking interaction between Ket molecules could serve as an anchor, and hydrogen bonded-induced β-sheets and hydrophilic/hydrophobic balance between L-VEVE peptide play structure-directing role in forming filament-like or nanoribbon morphology. This work provides a new sight to rationally design and precisely control the nanostructure of PDCs based on aromatic fragment.

scholarly journals Towards supramolecular nanostructured materials: control of the self-assembly of ionic bent-core amphiphiles

2020 ◽  
Vol 8 (6) ◽  
pp. 1998-2007 ◽  
Author(s):  
Martín Castillo-Vallés ◽  
Miguel Cano ◽  
Ana Bermejo-Sanz ◽  
Nélida Gimeno ◽  
M. Blanca Ros
Keyword(s):  
Nanostructured Materials ◽  
Self Assembly ◽  
Molecular Design ◽  
The Self ◽  
Bottom Up

Bottom-up self-assembly: the formation of mesophases and nanostructures in solution from ionic bent-core dendrimers has been systematically studied by molecular design.

scholarly journals Aqueous Photon Upconversion by Anionic Acceptors Self-Assembled on Cationic Bilayer Membranes with a Long Triplet Lifetime

2019 ◽  
Vol 01 (01) ◽  
pp. 043-049
Author(s):  
Deepak Asthana ◽  
Shota Hisamitsu ◽  
Masa-aki Morikawa ◽  
Pengfei Duan ◽  
Takuya Nakashima ◽  
...  
Keyword(s):  
Self Assembly ◽  
Molecular Design ◽  
Luminescence Spectra ◽  
Scanning Calorimetry ◽  
Triplet Energy ◽  
Bilayer Membranes ◽  
Excitation Light ◽  
Hydrogen Bond Networks ◽  
Inner Surface ◽  
Triplet Lifetime

Anionic 9,10-diphenylanthracene chromophores electrostatically bound to cationic, chiral bilayer membranes show ordered self-assembly in water. The integrity of the chromophore-accumulated aqueous bilayer membranes is ensured by multiple hydrogen-bond networks introduced in the bilayer, which allowed adaptive accommodation of the guest chromophores at the inner surface of the bilayer while maintaining their cohesive interactions. The regular chromophore alignment in the aqueous assembly is confirmed by differential scanning calorimetry, circular dichroism, and circularly polarized luminescence spectra. Excitonic migration of triplet energy occurs among the chromophores densely organized at the inner surface of the bilayer, which lead to triplet–triplet annihilation-based photon upconversion (TTA-UC). This acceptor-bilayer self-assemblies show a notably long triplet lifetime of 8.0 ms, which allows TTA-UC at sufficiently low excitation light intensity. These results demonstrate the usefulness of the simple electrostatic accumulation approach for TTA-UC chromophores where the suitable molecular design of the TTA-UC chromophore-integrated bilayer membranes plays a key role.

Self-assembled blue-light emitting materials for their liquid crystalline and OLED applications: from a simple molecular design to supramolecular materials

2020 ◽  
Vol 5 (10) ◽  
pp. 1691-1705
Author(s):  
Vinay S. Sharma ◽  
Anuj S. Sharma ◽  
Nikhil K. Agarwal ◽  
Priyanka A. Shah ◽  
Pranav S. Shrivastav
Keyword(s):  
Liquid Crystals ◽  
Blue Light ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Molecular Design ◽  
Supramolecular Materials ◽  
Light Emitting ◽  
New Family ◽  
Self Assembled

A new family of blue-light-emitting supramolecular bowl-shaped columnar hexagonal liquid crystals based on p-tert-butylcalix[4]arene and functionalized via chalconyl–ester-linked biphenyl amine derivatives form a self-assembly and their applications.

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