Transportation of Poorly Soluble Drug Molecules from the Organic Phase to the Aqueous Phase by Using Phosphorylated Calixarenes

2011 ◽  
Vol 56 (12) ◽  
pp. 4473-4479 ◽  
Author(s):  
Mevlüt Bayrakcı ◽  
Şeref Ertul ◽  
Mustafa Yilmaz
Keyword(s):  
Aqueous Phase ◽  
Organic Phase ◽  
Drug Molecules ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Studies on the Preparation, Characterization and Solubility of -Cyclodextrin-Roxythromycin Inclusion Complexes

2009 ◽  
Vol 2 (2) ◽  
pp. 523-530
Author(s):  
D. Nagasamy Venkatesh ◽  
S. Karthick ◽  
M. Umesh ◽  
G. Vivek ◽  
R.M. Valliappan ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Inclusion Complexes ◽  
Phase Solubility ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
X Ray ◽  
Ir Studies ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Roxythromycin/ β-cyclodextrin (Roxy/ β-CD) dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of roxythromycin was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:1 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), X-ray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.

Extraction of hafnium(IV) with organophosphorus reagents from solutions of mineral acids mixtures

1979 ◽  
Vol 44 (12) ◽  
pp. 3656-3664
Author(s):  
Oldřich Navrátil ◽  
Jiří Smola ◽  
Rostislav Kolouch
Keyword(s):  
Ionic Strength ◽  
Aqueous Phase ◽  
Organic Phase ◽  
Perchloric Acid ◽  
Synergic Effect ◽  
Salting Out ◽  
Initial Concentration ◽  
Mixed Complexes ◽  
Synergic Extraction ◽  
Mineral Acids

Extraction of hafnium(IV) was studied from solutions of mixtures of perchloric and nitric acids and of perchloric and hydrochloric acids for constant ionic strength, I = 2, 4, 6, or 8, and for cHf 4 . 10-4 mol l-1. The organic phase was constituted by solutions of some acidic or neutral organophosphorus reagents or of 2-thenoyltrifluoroacetone, 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone, or N-benzoyl-N-phenylhydroxylamine in benzene, chloroform, or n-octane. A pronounced synergic extraction of hafnium proceeds only on applying organophosphorus reagents from an aqueous phase whose acidity is not lower than 3M-(HClO4 + HNO3) or 5M-(HClO4 + HCl). The synergic effect was not affected markedly by a variation of the initial concentration of hafnium in the range 1 . 10-8 -4 .10-4 mol l-1, it lowered with increasing initial concentration of the organophosphorus reagent and decreasing concentration of the H+ ions. It is suggested that the hafnium passes into the organic phase in the form of mixed complexes, the salting-out effect of perchloric acid playing an appreciable part.

Impact of Drug-Polymer Interaction in Amorphous Solid Dispersion Aiming for the Supersaturation of Poorly Soluble Drug in Biorelevant Medium

2020 ◽  
Vol 21 (5) ◽  
Author(s):  
Cassiana Mendes ◽  
Rafael G. Andrzejewski ◽  
Juliana M. O. Pinto ◽  
Leice M. R. de Novais ◽  
Andersson Barison ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Amorphous Solid ◽  
Amorphous Solid Dispersion ◽  
Poorly Soluble ◽  
Poorly Soluble Drug ◽  
Drug Polymer Interaction ◽  
Biorelevant Medium ◽  
Polymer Interaction

Multicomponent Amorphous Nanofibers Electrospun from Hot Aqueous Solutions of a Poorly Soluble Drug

2010 ◽  
Vol 27 (11) ◽  
pp. 2466-2477 ◽  
Author(s):  
Deng-Guang Yu ◽  
Li-Dong Gao ◽  
Kenneth White ◽  
Christopher Branford-White ◽  
Wei-Yue Lu ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

In vitro models to evaluate the permeability of poorly soluble drug entities: Challenges and perspectives

2012 ◽  
Vol 45 (3) ◽  
pp. 235-250 ◽  
Author(s):  
Stephen T. Buckley ◽  
Sarah M. Fischer ◽  
Gert Fricker ◽  
Martin Brandl
Keyword(s):  
In Vitro Models ◽  
Poorly Soluble ◽  
Poorly Soluble Drug

Solubilization behavior of a poorly soluble drug under combined use of surfactants and cosolvents

2006 ◽  
Vol 28 (1-2) ◽  
pp. 7-14 ◽  
Author(s):  
Kohsaku Kawakami ◽  
Naohiko Oda ◽  
Kyoko Miyoshi ◽  
Takeshi Funaki ◽  
Yasuo Ida
Keyword(s):  
Combined Use ◽  
Poorly Soluble ◽  
Poorly Soluble Drug
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