Determining the Gibbs Energies of Hydrogen-Bonding Interactions of Proton-Accepting Solutes in Aqueous Solutions from Thermodynamic Data at 298 K with Regard to the Hydrophobic Effect

2011 ◽  
Vol 56 (4) ◽  
pp. 1438-1442 ◽  
Author(s):  
Igor A. Sedov ◽  
Boris N. Solomonov
Keyword(s):  
Hydrogen Bonding ◽  
Aqueous Solutions ◽  
Thermodynamic Data ◽  
Hydrophobic Effect ◽  
Gibbs Energies ◽  
Hydrogen Bonding Interactions

scholarly journals A polyaromatic receptor with high androgen affinity

2019 ◽  
Vol 5 (4) ◽  
pp. eaav3179 ◽  
Author(s):  
Masahiro Yamashina ◽  
Takahiro Tsutsui ◽  
Yoshihisa Sei ◽  
Munetaka Akita ◽  
Michito Yoshizawa
Keyword(s):  
Hydrogen Bonding ◽  
Sex Hormones ◽  
Single Molecule ◽  
High Selectivity ◽  
Hydrophobic Effect ◽  
Molecular Receptors ◽  
Synthetic Receptor ◽  
Hydrogen Bonding Interactions ◽  
Male Hormones ◽  
Steroid Sex Hormones

Biological receptors distinguish and bind steroid sex hormones, e.g., androgen-, progestogen-, and estrogen-type hormones, with high selectivity. To date, artificial molecular receptors have been unable to discriminate between these classes of biosubstrates. Here, we report that an artificial polyaromatic receptor preferentially binds a single molecule of androgenic hormones, known as “male” hormones (indicated with m), over progestogens and estrogens, known as “female” hormones (indicated with f), in water. Competitive experiments established the binding selectivity of the synthetic receptor for various sex hormones to be testosterone (m) > androsterone (m) >> progesterone (f) > β-estradiol (f) > pregnenolone (f) > estriol (f). These bindings are driven by the hydrophobic effect, and the observed selectivity arises from multiple CH-π contacts and hydrogen-bonding interactions in the semirigid polyaromatic cavity. Furthermore, micromolar fluorescence detection of androgen was demonstrated using the receptor containing a fluorescent dye in water.

Intramolecular Hydrogen Bonding Facilitates Electrocatalytic Reduction of Nitrite in Aqueous Solutions

2019 ◽  
Vol 58 (14) ◽  
pp. 9443-9451 ◽  
Author(s):  
Song Xu ◽  
Hyuk-Yong Kwon ◽  
Daniel C. Ashley ◽  
Chun-Hsing Chen ◽  
Elena Jakubikova ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Aqueous Solutions ◽  
Intramolecular Hydrogen Bonding ◽  
Electrocatalytic Reduction ◽  
Intramolecular Hydrogen

Theoretical study of hydrogen bonding interactions in substituted nitroxide radicals

2021 ◽  
Author(s):  
Thufail M. Ismail ◽  
Neetha Mohan ◽  
P. K. Sajith
Keyword(s):  
Hydrogen Bonding ◽  
Interaction Energy ◽  
Electrostatic Potential ◽  
Molecular Electrostatic Potential ◽  
Theoretical Study ◽  
Nitroxide Radicals ◽  
Hydrogen Bonding Interactions ◽  
Bonded Complexes ◽  
Hydrogen Bonded

Interaction energy (Eint) of hydrogen bonded complexes of nitroxide radicals can be assessed in terms of the deepest minimum of molecular electrostatic potential (Vmin).

scholarly journals Circular linkage of intramolecular multi-hydrogen bonding frameworks through nucleophilic substitutions of β-dicarbonyls onto cyanuric chloride and subsequent tautomerisation

RSC Advances ◽  
2020 ◽  
Vol 10 (64) ◽  
pp. 39033-39036
Author(s):  
Ayano Awatani ◽  
Masaaki Suzuki
Keyword(s):  
Hydrogen Bonding ◽  
Cyanuric Chloride ◽  
Nucleophilic Substitutions ◽  
Hydrogen Bonding Interactions ◽  
Triazine Derivatives

Triply β-dicarbonyl-embedded 1,3,5-triazine derivatives result in formation of circular linkage of resonance-assisted hydrogen bonding interactions, which can be regarded as well-delocalized resonance hybrids.

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