Versatile, Sensitive, and Robust Native LC–MS Platform for Intact Mass Analysis of Protein Drugs

2020 ◽  
Vol 31 (10) ◽  
pp. 2171-2179
Author(s):  
Yuetian Yan ◽  
Tao Xing ◽  
Shunhai Wang ◽  
Ning Li
Keyword(s):  
Protein Drugs ◽  
Mass Analysis ◽  
Intact Mass

Intact Mass Analysis of Complex Therapeutic Proteins under Native Conditions

2017 ◽  
Vol 37 (15) ◽  
pp. 26-27
Author(s):  
Simon Cubbon ◽  
Aaron Bailey ◽  
Kai Scheffler
Keyword(s):  
Therapeutic Proteins ◽  
Mass Analysis ◽  
Intact Mass

scholarly journals Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

mAbs ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1214-1225 ◽  
Author(s):  
Aaron O. Bailey ◽  
Guanghui Han ◽  
Wilson Phung ◽  
Paul Gazis ◽  
Jennifer Sutton ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Dynamic Range ◽  
Native Mass Spectrometry ◽  
Mass Analysis ◽  
Intact Mass

Direct quantitation of therapeutic antibodies for pharmacokinetic studies using immuno-purification and intact mass analysis

Bioanalysis ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 203-213 ◽  
Author(s):  
Lisa A Vasicek ◽  
Xin Zhu ◽  
Daniel S Spellman ◽  
Kevin P Bateman
Keyword(s):  
Pharmacokinetic Studies ◽  
Therapeutic Antibodies ◽  
Mass Analysis ◽  
Intact Mass

Combination of SDS-PAGE and intact mass analysis for rapid determination of heterogeneities in monoclonal antibody therapeutics

2017 ◽  
Vol 38 (9-10) ◽  
pp. 1344-1352 ◽  
Author(s):  
Hideaki Yamada ◽  
Chiemi Matsumura ◽  
Keita Yamada ◽  
Koichiro Teshima ◽  
Takashi Hiroshima ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Rapid Determination ◽  
Mass Analysis ◽  
Antibody Therapeutics ◽  
Sds Page ◽  
Intact Mass

scholarly journals Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms

2019 ◽  
Vol 91 (17) ◽  
pp. 10937-10942 ◽  
Author(s):  
Leah V. Schaffer ◽  
Trisha Tucholski ◽  
Michael R. Shortreed ◽  
Ying Ge ◽  
Lloyd M. Smith
Keyword(s):  
Human Heart ◽  
Mass Analysis ◽  
Intact Mass
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