scholarly journals Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers

2020 ◽  
Vol 142 (4) ◽  
pp. 1704-1709 ◽  
Author(s):  
Jacob C. Green ◽  
Joseph M. Zanghi ◽  
Simon J. Meek
Keyword(s):  
Enantioselective Synthesis ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Homoallylic Amines

Enantioselective synthesis of quaternary carbon centers through Michael-type alkylation of chiral imines

1985 ◽  
Vol 107 (1) ◽  
pp. 273-274 ◽  
Author(s):  
Michel Pfau ◽  
Gilbert Revial ◽  
Andre Guingant ◽  
Jean d'Angelo
Keyword(s):  
Enantioselective Synthesis ◽  
Quaternary Carbon ◽  
Carbon Centers ◽  
Chiral Imines

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

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