Dual-Color Emissive AIEgen for Specific and Label-Free Double-Stranded DNA Recognition and Single-Nucleotide Polymorphisms Detection

Yuting Gao; Zhenyan He; Xuewen He; Haoke Zhang; Jun Weng; Xiangliang Yang; Fanling Meng; Liang Luo; Ben Zhong Tang

doi:10.1021/jacs.9b09239

Dual-Color Emissive AIEgen for Specific and Label-Free Double-Stranded DNA Recognition and Single-Nucleotide Polymorphisms Detection

Journal of the American Chemical Society ◽

10.1021/jacs.9b09239 ◽

2019 ◽

Vol 141 (51) ◽

pp. 20097-20106 ◽

Cited By ~ 14

Author(s):

Yuting Gao ◽

Zhenyan He ◽

Xuewen He ◽

Haoke Zhang ◽

Jun Weng ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Dna Recognition ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Single Nucleotide ◽

Double Stranded Dna ◽

Dual Color

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Biocomputing label-free security system based on homogenous ligation chain reaction-induced dramatic change in melting temperature for screening single nucleotide polymorphisms

Talanta ◽

10.1016/j.talanta.2020.121141 ◽

2020 ◽

Vol 218 ◽

pp. 121141

Author(s):

Chang Xue ◽

Xin Yu ◽

Shuyao Hu ◽

Mengxue Luo ◽

Zhifa Shen ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Melting Temperature ◽

Security System ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Chain Reaction ◽

Single Nucleotide

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Associations between Single Nucleotide Polymorphisms in Double-Stranded DNA Repair Pathway Genes and Familial Breast Cancer

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-1417 ◽

2009 ◽

Vol 15 (6) ◽

pp. 2192-2203 ◽

Cited By ~ 28

Author(s):

Mary E. Sehl ◽

Lucy R. Langer ◽

Jeanette C. Papp ◽

Lorna Kwan ◽

Joyce L. Seldon ◽

...

Keyword(s):

Breast Cancer ◽

Dna Repair ◽

Single Nucleotide Polymorphisms ◽

Familial Breast Cancer ◽

Nucleotide Polymorphisms ◽

Repair Pathway ◽

Single Nucleotide ◽

Double Stranded Dna

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The Label-Free Unambiguous Detection and Symbolic Display of Single Nucleotide Polymorphisms on DNA Origami

Nano Letters ◽

10.1021/nl104555t ◽

2011 ◽

Vol 11 (2) ◽

pp. 910-913 ◽

Cited By ~ 106

Author(s):

Hari K. K. Subramanian ◽

Banani Chakraborty ◽

Ruojie Sha ◽

Nadrian C. Seeman

Keyword(s):

Single Nucleotide Polymorphisms ◽

Dna Origami ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Single Nucleotide ◽

Unambiguous Detection

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Label Free Electrical Detection of Single Nucleotide Polymorphisms using Nanowire Biosensors

10.7567/ssdm.2007.d-8-3 ◽

2007 ◽

Author(s):

E. S. Selamat ◽

A. Agarwal ◽

N. Balasubramanian ◽

W.-T. Liu

Keyword(s):

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Electrical Detection ◽

Single Nucleotide

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Isothermal Discrimination of Single-Nucleotide Polymorphisms via Real-Time Kinetic Desorption and Label-Free Detection of DNA Using Silicon Photonic Microring Resonator Arrays

Analytical Chemistry ◽

10.1021/ac201659p ◽

2011 ◽

Vol 83 (17) ◽

pp. 6827-6833 ◽

Cited By ~ 57

Author(s):

Abraham J. Qavi ◽

Thomas M. Mysz ◽

Ryan C. Bailey

Keyword(s):

Single Nucleotide Polymorphisms ◽

Real Time ◽

Microring Resonator ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Single Nucleotide ◽

Silicon Photonic ◽

Label Free Detection ◽

Resonator Arrays

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Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis ◽

10.1016/j.mrfmmm.2004.01.002 ◽

2004 ◽

Vol 548 (1-2) ◽

pp. 97-105 ◽

Cited By ~ 39

Author(s):

Meiju Ji ◽

Peng Hou ◽

Song Li ◽

Nongyue He ◽

Zuhong Lu

Keyword(s):

Single Nucleotide Polymorphisms ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Dual Color

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Peptide Nucleic Acid-Assisted Label-free Detection of Single-Nucleotide Polymorphisms Based on Light Scattering of Carbon Nanotubes

ACS Omega ◽

10.1021/acsomega.8b02655 ◽

2018 ◽

Vol 3 (12) ◽

pp. 17835-17841 ◽

Cited By ~ 4

Author(s):

Wanxing Xu ◽

Shu Xing ◽

Xiaojun Xu ◽

Mengjia Xu ◽

Pan Fu ◽

...

Keyword(s):

Carbon Nanotubes ◽

Light Scattering ◽

Nucleic Acid ◽

Single Nucleotide Polymorphisms ◽

Peptide Nucleic Acid ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Single Nucleotide ◽

Label Free Detection

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Label-free detection of single-nucleotide polymorphisms associated with myeloid differentiation-2 using a nanostructured biosensor

Biosensors and Bioelectronics ◽

10.1016/j.bios.2013.05.049 ◽

2013 ◽

Vol 49 ◽

pp. 506-511 ◽

Cited By ~ 6

Author(s):

Yu-Ting Chin ◽

En-Chih Liao ◽

Chia-Che Wu ◽

Gou-Jen Wang ◽

Jaw-Ji Tsai

Keyword(s):

Single Nucleotide Polymorphisms ◽

Myeloid Differentiation ◽

Nucleotide Polymorphisms ◽

Label Free ◽

Single Nucleotide ◽

Label Free Detection

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A novel automated assay with dual-color hybridization for single-nucleotide polymorphisms genotyping on gold magnetic nanoparticle array

Analytical Biochemistry ◽

10.1016/j.ab.2010.05.016 ◽

2010 ◽

Vol 405 (1) ◽

pp. 141-143 ◽

Cited By ~ 18

Author(s):

Song Li ◽

Hongna Liu ◽

Lishang Liu ◽

Lan Tian ◽

Nongyue He

Keyword(s):

Single Nucleotide Polymorphisms ◽

Magnetic Nanoparticle ◽

Nanoparticle Array ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Automated Assay ◽

Dual Color

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Distinguishing Single Nucleotide Polymorphisms of DNA Using Fluorescent Oligonucleotide Probe Containing 2-Aminopurine

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.522-524.281 ◽

2014 ◽

Vol 522-524 ◽

pp. 281-284

Author(s):

Lin Bai ◽

Hao Qin ◽

Yu Guo Jiao

Keyword(s):

Single Nucleotide Polymorphisms ◽

Fluorescence Intensity ◽

Fluorescence Spectra ◽

Oligonucleotide Probe ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Degree Of Reduction ◽

Double Stranded Dna

The fluorescence intensity of double-stranded DNA (ds-DNA) hybridized by fluorescent 2-aminopurine (2-AP) oligonucleotide probe and different mismatched bases was studied by fluorescence spectra in this paper. The experiment designed and synthesised four oligonucleotide sequences with the bases of adenine (A), cytosine (C), guanine (G), thymine (T), and determined the fluorescence intensity of the mismatched double-stranded DNA. The results implied that the fluorescence intensity of oligonucleotide probe was varied due to different mismatched bases. And the fluorescence intensity was 546.9 with the ratio of 3.13, which showed a significantly increase as the mismatched base was A. While the mismatched base was T, the fluorescence intensity quenched to 43.26, as the ratio was 0.25. For C and G, the fluorescence intensity of 2-AP was 99.14 and 89.03, respectively, which showed a different degree of reduction.

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