Three-Dimensional Nucleic-Acid-Based Constitutional Dynamic Networks: Enhancing Diversity through Complexity of the Systems

2019 ◽  
Vol 141 (41) ◽  
pp. 16461-16470 ◽  
Author(s):  
Liang Yue ◽  
Shan Wang ◽  
Itamar Willner
Keyword(s):  
Nucleic Acid ◽  
Dynamic Networks ◽  
Three Dimensional

scholarly journals DNA-based constitutional dynamic networks as functional modules for logic gates and computing circuit operations

2021 ◽  
Vol 12 (15) ◽  
pp. 5473-5483
Author(s):  
Zhixin Zhou ◽  
Jianbang Wang ◽  
R. D. Levine ◽  
Francoise Remacle ◽  
Itamar Willner
Keyword(s):  
Nucleic Acid ◽  
Dynamic Networks ◽  
Dynamic Network ◽  
Logic Gates ◽  
Functional Modules ◽  
Logic Operations

A nucleic acid-based constitutional dynamic network (CDN) provides a single functional computational module for diverse input-guided logic operations and computing circuits.

scholarly journals Integration of photocatalytic and dark-operating catalytic biomimetic transformations through DNA-based constitutional dynamic networks

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Chen Wang ◽  
Michael P. O’Hagan ◽  
Ehud Neumann ◽  
Rachel Nechushtai ◽  
Itamar Willner
Keyword(s):  
Nucleic Acid ◽  
Energy Harvesting ◽  
Information Transfer ◽  
Dynamic Networks ◽  
Research Direction ◽  
Cellular Biology ◽  
Dynamic Feedback ◽  
Dynamic Coupling ◽  
Metabolic Processes ◽  
Catalytic Functions

AbstractNucleic acid-based constitutional dynamic networks (CDNs) have recently emerged as versatile tools to control a variety of catalytic processes. A key challenge in the application of these systems is achieving intercommunication between different CDNs to mimic the complex interlinked networks found in cellular biology. In particular, the possibility to interface photochemical ‘energy-harvesting’ processes with dark-operating ‘metabolic’ processes, in a similar way to plants, represents an up to now unexplored yet enticing research direction. The present study introduces two CDNs that allow the intercommunication of photocatalytic and dark-operating catalytic functions mediated by environmental components that facilitate the dynamic coupling of the networks. The dynamic feedback-driven intercommunication of the networks is accomplished via information transfer between the two CDNs effected by hairpin fuel strands in the environment of the system, leading to the coupling of the photochemical and dark-operating modules.

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues

2020 ◽  
Vol 13 (636) ◽  
pp. eaaz5599 ◽  
Author(s):  
Kelan Chen ◽  
Richard W. Birkinshaw ◽  
Alexandra D. Gurzau ◽  
Iromi Wanigasuriya ◽  
Ruoyun Wang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Muscular Dystrophy ◽  
Three Dimensional ◽  
Underlying Mechanism ◽  
Structural Features ◽  
Facioscapulohumeral Muscular Dystrophy ◽  
Dimensional Structure ◽  
Nucleic Acid Binding ◽  
X Ray Crystallography ◽  
Hinge Domain

Structural maintenance of chromosomes flexible hinge domain containing 1 (SMCHD1) is an epigenetic regulator in which polymorphisms cause the human developmental disorder, Bosma arhinia micropthalmia syndrome, and the degenerative disease, facioscapulohumeral muscular dystrophy. SMCHD1 is considered a noncanonical SMC family member because its hinge domain is C-terminal, because it homodimerizes rather than heterodimerizes, and because SMCHD1 contains a GHKL-type, rather than an ABC-type ATPase domain at its N terminus. The hinge domain has been previously implicated in chromatin association; however, the underlying mechanism involved and the basis for SMCHD1 homodimerization are unclear. Here, we used x-ray crystallography to solve the three-dimensional structure of the Smchd1 hinge domain. Together with structure-guided mutagenesis, we defined structural features of the hinge domain that participated in homodimerization and nucleic acid binding, and we identified a functional hotspot required for chromatin localization in cells. This structure provides a template for interpreting the mechanism by which patient polymorphisms within the SMCHD1 hinge domain could compromise function and lead to facioscapulohumeral muscular dystrophy.

A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator

2019 ◽  
Vol 55 (45) ◽  
pp. 6453-6456 ◽  
Author(s):  
Ze-Zhou Yang ◽  
Zhi-Bin Wen ◽  
Xin Peng ◽  
Ya-Qin Chai ◽  
Wen-Bin Liang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Three Dimensional ◽  
Nucleic Acid Amplification ◽  
Ultrasensitive Detection ◽  
Fluorescent Assay ◽  
Target Recycling ◽  
Dna Walker ◽  
G Quadruplex

A fluorescent assay for the ultrasensitive detection of miRNA-21 is based on immobilization of PPIX as signal indicators in massive G-quadruplex structures obtained by target recycling, three-dimensional DNA walker and RCA coupled cascade nucleic acid amplification.

Address of the President Lord Blackett, O.M., C.H. at the Anniversary Meeting, 30 November 1970

1971 ◽  
Vol 177 (1046) ◽  
pp. 1-14
Keyword(s):  
Natural Products ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Biological Systems ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Theoretical Knowledge ◽  
Three Dimensional Structure ◽  
Subsequent Determination

Todd has made highly significant contributions to the chemistry of natural products, in particular in relation to compounds which play important roles in biological systems. His researches on vitamins B 1 , E and B 12 were most elegant and have had far-reaching implications, but none more so than his structural and synthetic studies in the nucleic acid field. Here he developed methods for the synthesis of the nucleosides and for their phosphorylation; his work on the way they are combined made possible the subsequent determination of the three-dimensional structure of the nucleic acids thereby providing the basis for much of the exciting activity in the nucleotide field today. Todd’s achievements arise out of a rare combination of theoretical knowledge and outstanding experimental skill, with the most judicious exploitation of modern techniques. His work and his quality as an investigator have been widely recognized by biologists as well as by organic chemists.

Human Primary Osteoarthritic Chondrocytes Reared in Long‐term, Serum‐free, Three‐dimensional Alginate Culture Remain Metabolically Stable: A Nucleic Acid Study

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Andrea Healy ◽  
Gregory Philip Morris ◽  
Hannah Popper ◽  
Patrisia Mattioli ◽  
Patrick Laird ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Three Dimensional ◽  
Serum Free ◽  
Osteoarthritic Chondrocytes

Evaluation of Three-Dimensional Microchannel Glass Biochips for Multiplexed Nucleic Acid Fluorescence Hybridization Assays

2001 ◽  
Vol 73 (11) ◽  
pp. 2412-2420 ◽  
Author(s):  
Vincent Benoit ◽  
Adam Steel ◽  
Matt Torres ◽  
Yong-Yi Yu ◽  
Hongjun Yang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Three Dimensional ◽  
Hybridization Assays
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