Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor

Annet E.M. Blom; Hugo Rego Campello; Henry A. Lester; Timothy Gallagher; Dennis A. Dougherty

doi:10.1021/jacs.9b06580

Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor

Journal of the American Chemical Society ◽

10.1021/jacs.9b06580 ◽

2019 ◽

Vol 141 (40) ◽

pp. 15840-15849 ◽

Cited By ~ 3

Author(s):

Annet E.M. Blom ◽

Hugo Rego Campello ◽

Henry A. Lester ◽

Timothy Gallagher ◽

Dennis A. Dougherty

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Binding Interactions ◽

Cytisine Derivatives

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Synthesis, Binding, and Modeling Studies of New Cytisine Derivatives, as Ligands for Neuronal Nicotinic Acetylcholine Receptor Subtypes

Journal of Medicinal Chemistry ◽

10.1021/jm900225j ◽

2009 ◽

Vol 52 (14) ◽

pp. 4345-4357 ◽

Cited By ~ 29

Author(s):

Bruno Tasso ◽

Caterina Canu Boido ◽

Emanuela Terranova ◽

Cecilia Gotti ◽

Loredana Riganti ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Subtypes ◽

Nicotinic Acetylcholine ◽

Cytisine Derivatives ◽

Modeling Studies

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Possible Drug Candidates for Alzheimers Disease Deduced from Studying their Binding Interactions with α7 Nicotinic Acetylcholine Receptor

Medicinal Chemistry ◽

10.2174/157340609788185909 ◽

2009 ◽

Vol 5 (3) ◽

pp. 250-262 ◽

Cited By ~ 30

Author(s):

Ruo-Xu Gu ◽

Hui Gu ◽

Zhi-Yuan Xie ◽

Jing-Fang Wang ◽

Hugo Arias ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Alzheimers Disease ◽

Nicotinic Acetylcholine ◽

Binding Interactions ◽

Drug Candidates

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Probing Binding Interactions of Agonists with the α6β2 Nicotinic Acetylcholine Receptor

Biophysical Journal ◽

10.1016/j.bpj.2015.11.3220 ◽

2016 ◽

Vol 110 (3) ◽

pp. 603a

Author(s):

Michael R. Post ◽

Dennis A. Dougherty ◽

Henry A. Lester

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Binding Interactions

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Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes

Neuropharmacology ◽

10.1016/s0028-3908(03)00025-x ◽

2003 ◽

Vol 44 (4) ◽

pp. 503-515 ◽

Cited By ~ 62

Author(s):

Y Slater

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Neuronal Nicotinic Acetylcholine Receptor ◽

Receptor Subtypes ◽

Nicotinic Acetylcholine ◽

Cytisine Derivatives

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Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human <i>α</i>4<i>β</i>2 Nicotinic Acetylcholine Receptor

Journal of Biomedical Science and Engineering ◽

10.4236/jbise.2016.91005 ◽

2016 ◽

Vol 09 (01) ◽

pp. 41-100 ◽

Cited By ~ 3

Author(s):

Shu Mao ◽

Hui Wen Ng ◽

Michael Orr ◽

Heng Luo ◽

Hao Ye ◽

...

Keyword(s):

Ligand Binding ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Homology Model ◽

Extracellular Domain ◽

Nicotinic Acetylcholine ◽

Binding Interactions

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Binding Interactions of NS6740, a Silent Agonist of the α7 Nicotinic Acetylcholine Receptor

Molecular Pharmacology ◽

10.1124/mol.119.116244 ◽

2019 ◽

Vol 96 (2) ◽

pp. 212-218

Author(s):

Catriona E. W. Blunt ◽

Dennis A. Dougherty

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Binding Interactions

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Search for Nootropic Substances Based on Molecular Docking of Methanepyrido[1,2-a][1, 5]Diazocin[(-)-Cytisine] Derivatives to the Active Center of the Nicotinic Acetylcholine Receptor

Pharmaceutical Chemistry Journal ◽

10.1007/s11094-015-1333-6 ◽

2015 ◽

Vol 49 (9) ◽

pp. 582-586 ◽

Cited By ~ 1

Author(s):

A. Ya. Gerchikov ◽

M. N. Vasil’ev ◽

V. R. Khairullina ◽

I. P. Tsypysheva ◽

F. S. Zarudii

Keyword(s):

Molecular Docking ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Active Center ◽

Nicotinic Acetylcholine ◽

Cytisine Derivatives

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Fluorescent labeled α-conotoxin GI: binding interactions with the nicotinic acetylcholine receptor and monoclonal antibodies

Toxicon ◽

10.1016/0041-0101(96)80903-2 ◽

1996 ◽

Vol 34 (3) ◽

pp. 301

Author(s):

J.D. Ashcom ◽

B.G. Stiles

Keyword(s):

Monoclonal Antibodies ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Binding Interactions

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Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70598-x ◽

2008 ◽

Vol 2008 ◽

pp. 109-110

Author(s):

L.T. Tanoue

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Medicine ◽

10.1016/s0084-3873(08)70096-8 ◽

2007 ◽

Vol 2007 ◽

pp. 143-145

Author(s):

N.H. Hanna

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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