scholarly journals Interplay between Short-Range Attraction and Long-Range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein–RNA Complexes

2019 ◽  
Vol 141 (37) ◽  
pp. 14593-14602 ◽  
Author(s):  
Ibraheem Alshareedah ◽  
Taranpreet Kaur ◽  
Jason Ngo ◽  
Hannah Seppala ◽  
Liz-Audrey Djomnang Kounatse ◽  
...  
Keyword(s):  
Long Range ◽  
Short Range ◽  
Rna Complexes

scholarly journals Interplay Between Short-range Attraction and Long-range Repulsion Controls Reentrant Liquid Condensation of Ribonucleoprotein-RNA Complexes

2019 ◽  
Author(s):  
Ibraheem Alshareedah ◽  
Taranpreet Kaur ◽  
Jason Ngo ◽  
Hannah Seppala ◽  
Liz-Audrey Djomnang Kounatse ◽  
...  
Keyword(s):  
Phase Separation ◽  
Long Range ◽  
Short Range ◽  
Rna Binding ◽  
Driving Forces ◽  
Low Complexity ◽  
Model Systems ◽  
Supramolecular Organization ◽  
Cluster Phase ◽  
Rna Complexes

AbstractIn eukaryotic cells, ribonucleoproteins (RNPs) form mesoscale condensates by liquid-liquid phase separation that play essential roles in subcellular dynamic compartmentalization. The formation and dissolution of many RNP condensates are finely dependent on the RNA-to-RNP ratio, giving rise to a window-like phase separation behavior. This is commonly referred to as reentrant liquid condensation (RLC). Here, using RNP-inspired polypeptides with low-complexity RNA-binding sequences as well as the C-terminal disordered domain of the ribonucleoprotein FUS as model systems, we investigate the molecular driving forces underlying this non-monotonous phase transition. We show that an interplay between short-range cation-π attractions and long-range electrostatic forces governs the heterotypic RLC of RNP-RNA complexes. Short-range attractions, which can be encoded by both polypeptide chain primary sequence and nucleic acid base sequence, are activated by RNP-RNA condensate formation. After activation, the short-range forces regulate material properties of polypeptide-RNA condensates and subsequently oppose their reentrant dissolution. In the presence of excess RNA, a competition between short-range attraction and long-range electrostatic repulsion drives the formation of a colloid-like cluster phase. With increasing short-range attraction, the fluid dynamics of the cluster phase is arrested, leading to the formation of a colloidal gel. Our results reveal that phase behavior, supramolecular organization, and material states of RNP-RNA assemblies are controlled by a dynamic interplay between molecular interactions at different length scales.

scholarly journals Structural basis of long-range to short-range synaptic transition in NHEJ

Nature ◽  
2021 ◽  
Author(s):  
Siyu Chen ◽  
Linda Lee ◽  
Tasmin Naila ◽  
Susan Fishbain ◽  
Annie Wang ◽  
...  
Keyword(s):  
Long Range ◽  
Short Range ◽  
Structural Basis

scholarly journals Comparison of short-range order in irradiated dysprosium titanates

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Roman Sherrod ◽  
Eric C. O’Quinn ◽  
Igor M. Gussev ◽  
Cale Overstreet ◽  
Joerg Neuefeind ◽  
...  
Keyword(s):  
Long Range ◽  
Short Range ◽  
Structural Model ◽  
Ion Irradiation ◽  
Function Analysis ◽  
Ion Beam ◽  
Structural Response ◽  
Heavy Ion ◽  
Range Order ◽  
Radiation Resistant

AbstractThe structural response of Dy2TiO5 oxide under swift heavy ion irradiation (2.2 GeV Au ions) was studied over a range of structural length scales utilizing neutron total scattering experiments. Refinement of diffraction data confirms that the long-range orthorhombic structure is susceptible to ion beam-induced amorphization with limited crystalline fraction remaining after irradiation to 8 × 1012 ions/cm2. In contrast, the local atomic arrangement, examined through pair distribution function analysis, shows only subtle changes after irradiation and is still described best by the original orthorhombic structural model. A comparison to Dy2Ti2O7 pyrochlore oxide under the same irradiation conditions reveals a different behavior: while the dysprosium titanate pyrochlore is more radiation resistant over the long-range with smaller degree of amorphization as compared to Dy2TiO5, the former involves more local atomic rearrangements, best described by a pyrochlore-to-weberite-type transformation. These results highlight the importance of short-range and medium-range order analysis for a comprehensive description of radiation behavior.

SHORT-RANGE AND LONG-RANGE ORDER OF TITANIUM IN Ti1+xS2

1977 ◽  
Vol 38 (C7) ◽  
pp. C7-202-C7-206 ◽  
Author(s):  
R. MORET ◽  
M. HUBER ◽  
R. COMÈS
Keyword(s):  
Long Range ◽  
Short Range ◽  
Range Order ◽  
Long Range Order

scholarly journals Short range smectic order driving long range nematic order: example of cuprates

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
R. S. Markiewicz ◽  
J. Lorenzana ◽  
G. Seibold ◽  
A. Bansil
Keyword(s):  
Long Range ◽  
Short Range ◽  
Nematic Order

ANDERSON LOCALIZATION FOR A MULTIDIMENSIONAL MODEL INCLUDING LONG RANGE POTENTIALS AND DISPLACEMENTS

2002 ◽  
Vol 14 (03) ◽  
pp. 273-302 ◽  
Author(s):  
HERIBERT ZENK
Keyword(s):  
Long Range ◽  
Anderson Model ◽  
Anderson Localization ◽  
Short Range ◽  
Energy Interval ◽  
Multidimensional Model ◽  
Short Summary

We give a short summary on how to combine and extend results of Combes and Hislop [2] (short range Anderson model with additional displacements), Kirsch, Stollmann and Stolz [13] and [14] (long range Anderson model without displacements) to get localization in an energy interval above the infimum of the almost sure spectrum for a continuous multidimensional Anderson model including long range potentials and displacements.

Study on the relationships of mechanical performance with the short-range and long-range structure of 500–900℃ carbonized fiber

2014 ◽  
Vol 45 (1) ◽  
pp. 33-47 ◽  
Author(s):  
Xue Lin ◽  
Chengguo Wang ◽  
Meijie Yu ◽  
Zhitao Lin ◽  
Yuzhen Liu
Keyword(s):  
Long Range ◽  
Short Range ◽  
Mechanical Performance
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