Epimerization of Tertiary Carbon Centers via Reversible Radical Cleavage of Unactivated C(sp3)–H Bonds

2018 ◽  
Vol 140 (30) ◽  
pp. 9678-9684 ◽  
Author(s):  
Yaxin Wang ◽  
Xiafei Hu ◽  
Cristian A. Morales-Rivera ◽  
Guo-Xing Li ◽  
Xin Huang ◽  
...  
Keyword(s):  
Carbon Centers ◽  
Tertiary Carbon ◽  
Radical Cleavage

Construction of Consecutive Chiral Non-racemic Quaternary and Tertiary Carbon Centers: A Short Synthetic Route to (-)-Acetomycin.

ChemInform ◽  
2004 ◽  
Vol 35 (7) ◽  
Author(s):  
Jun'ichi Uenishi ◽  
Motoi Kawatsura ◽  
Daiji Ikeda ◽  
Nobuhiro Muraoka
Keyword(s):  
Synthetic Route ◽  
Carbon Centers ◽  
Tertiary Carbon

scholarly journals Palladium-Catalyzed Diastereo- and Enantioselective Allylic Alkylation of Oxazolones with 1,3-Dienes Under Base-Free Conditions

2020 ◽  
Author(s):  
Haijian Yang ◽  
Dong Xing
Keyword(s):  
Catalytic System ◽  
Allylic Alkylation ◽  
Chiral Ligand ◽  
Palladium Hydride ◽  
Carbon Centers ◽  
Tertiary Carbon ◽  
Palladium Catalyzed

<p>Herein, we report a highly diastereo- and enantioselective allylic alkylation of oxozolones with 1,3-dienes by palladium-hydride catalyst under base-free conditions. With DTBM-SEGPHOS as the chiral ligand, a series of enantioenriched oxazolones bearing tertiary carbon centers were synthesized from substituted 1,3-dienes via exclusive 1,2-addition with moderate to good diastereoselectivities and high enantioselectivities. When simple 1,3-butadiene was used as the allyl precursor under this base-free catalytic system, 1,4-addition products were obtained in good yields with high regioselectivities. </p>

The conformational bias of aryl, arylsulfonyl geminally substituted tertiary carbon centers: applications in substrate-based stereocontrol

2006 ◽  
Vol 4 (9) ◽  
pp. 1806 ◽  
Author(s):  
Jeremy P. Scott ◽  
Peter R. Mullens ◽  
Sarah E. Brewer ◽  
Karel M. J. Brands ◽  
Jennifer R. Chilenski ◽  
...  
Keyword(s):  
Carbon Centers ◽  
Tertiary Carbon
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