scholarly journals Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer

2017 ◽  
Vol 139 (29) ◽  
pp. 9847-9850 ◽  
Author(s):  
David N. Primer ◽  
Gary A. Molander
Keyword(s):  
Cross Coupling ◽  
Alkyl Transfer ◽  
The Cross

A horizontal linear vibrator for measuring the cross-coupling coefficient of superconducting gravity gradiometers

Measurement ◽  
2021 ◽  
Vol 174 ◽  
pp. 109083
Author(s):  
Lu Zhang ◽  
Yuntao Qiu ◽  
Xikai Liu ◽  
Liang Chen ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Coupling Coefficient ◽  
Cross Coupling ◽  
Superconducting Gravity ◽  
The Cross

scholarly journals Divergent Pathways Regulate Ligand-Independent Activation of ERα in SK-N-BE Neuroblastoma and COS-1 Renal Carcinoma Cells

1998 ◽  
Vol 12 (6) ◽  
pp. 835-841
Author(s):  
Cesare Patrone ◽  
Elisabetta Gianazza ◽  
Sabrina Santagati ◽  
Paola Agrati ◽  
Adriana Maggi
Keyword(s):  
Cell Line ◽  
Intracellular Signaling ◽  
Steroid Receptors ◽  
Neuroblastoma Cell ◽  
Cross Coupling ◽  
Activation Function ◽  
Neuroblastoma Cell Line ◽  
Membrane Receptors ◽  
Insulin Dependent ◽  
The Cross

Abstract The α-estrogen receptor (ERα) transcriptional activity can be regulated either by binding to the cognate ligand or by intracellular signaling pathways responsive to a variety of factors acting through cell membrane receptors. Studies carried out in HeLa and COS-1 cells demonstrated that the cross-coupling between estrogen and growth factor receptors is mediated by p21ras and requires phosphorylation of a specific serine residue (Ser 118 in the human ERα and Ser 122 in mouse ERα) located in the ERα N-terminal activation function 1 (AF-1). Likewise, in the SK-N-BE neuroblastoma cell line p21ras is involved in the cross-coupling between insulin and ERα receptors. However, in this cell line Ser 122 is not necessary for insulin-dependent activation of unliganded ERα. In addition, after insulin activation, the electrophoretic mobility associated to serine hyperphosphorylation of ERα in SK-N-BE and in COS-1 cells is different. Our study rules out the possibility of tyrosine phosporylation in unliganded ERα activation by means of transactivation studies of ERα tyrosine mutants and analysis of Tyr phosphorylation immunoreactivity. The two cofactors for steroid receptors RIP 140 and SRC-1 do not seem to be specifically involved in the insulin-induced ERα transactivation. The present study demonstrates the possibility of an alternative, cell-specific pathway of cross-coupling between intracellular and membrane receptors, which might be of importance for the understanding of the physiological significance of this mode of activation in the nervous system.

Nickel-Catalyzed Reductive 1,3-Diene Formation from the Cross-Coupling of Vinyl Bromides

2021 ◽  
Author(s):  
Yunfei Sha ◽  
Jiandong Liu ◽  
Liang Wang ◽  
Demin Liang ◽  
Da Wu ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Open Chain ◽  
Vinyl Halides ◽  
The Cross

Facile construction of 1,3-dienes building upon cross-electrophile coupling of two open-chain vinyl halides is disclosed in this work, showing moderate chemoselectivities between the terminal bromoalkenes and internal vinyl bromides. The...

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