Direct Catalytic Desaturation of Lactams Enabled by Soft Enolization

2017 ◽  
Vol 139 (23) ◽  
pp. 7757-7760 ◽  
Author(s):  
Ming Chen ◽  
Guangbin Dong
Keyword(s):  
Soft Enolization

MgBr2·OEt2-Promoted Coupling of Ketones and Activated Acyl Donors via Soft Enolization: A Practical Synthesis of 1,3-Diketones

Synthesis ◽  
2008 ◽  
Vol 2008 (13) ◽  
pp. 2148-2152 ◽  
Author(s):  
Don Coltart ◽  
Daniel Lim ◽  
Guoqiang Zhou ◽  
Alexandra Livanos ◽  
Fang Fang
Keyword(s):  
Soft Enolization ◽  
Practical Synthesis ◽  
Acyl Donors

Direct Synthesis of 5-Acyl-3-oxy-4-pyrones Based On Acid-­Catalyzed Acylation of Enaminodiones with Acylbenzotriazoles via Soft Enolization

Synthesis ◽  
2020 ◽  
Vol 52 (15) ◽  
pp. 2267-2276 ◽  
Author(s):  
Dmitrii L. Obydennov ◽  
Viktoria V. Viktorova ◽  
Elena V. Chernyshova ◽  
Alexander S. Shirinkin ◽  
Sergey A. Usachev ◽  
...  
Keyword(s):  
Ring Opening ◽  
Direct Synthesis ◽  
Pyrone Ring ◽  
Mild Conditions ◽  
Soft Enolization ◽  
Acid Catalyzed

A novel convenient acid-catalyzed acylation of enaminodiones with acylbenzotriazoles via soft enolization has been developed for the direct synthesis of hard-to-reach 5-acyl-3-oxy-4-pyrones. The important advantages of the reaction include broad substrate scope, mild conditions, scalability, and readily isolation of products by crystallization without the use of chromatography. Further modification of the pyrone ring and synthesis of various azaheterocycles via ring-opening transformation have been demonstrated for the preparation of potential scaffolds for inhibition of metalloenzymes.

ChemInform Abstract: Acid-Base Pairs in Lewis Acidic Zeolites Promote Direct Aldol Reactions by Soft Enolization.

ChemInform ◽  
2015 ◽  
Vol 46 (47) ◽  
pp. no-no ◽  
Author(s):  
Jennifer D. Lewis ◽  
Stijn Van de Vyver ◽  
Yuriy Roman-Leshkov
Keyword(s):  
Aldol Reactions ◽  
Acid Base ◽  
Base Pairs ◽  
Soft Enolization ◽  
Acidic Zeolites
Sign in / Sign up

Export Citation Format

Share Document