scholarly journals Proton Transport Mechanism of M2 Proton Channel Studied by Laser-Induced pH Jump

2017 ◽  
Vol 139 (19) ◽  
pp. 6621-6628 ◽  
Author(s):  
Ban-Seok Jeong ◽  
R. Brian Dyer
Keyword(s):  
Proton Transport ◽  
Transport Mechanism ◽  
Proton Channel ◽  
Ph Jump ◽  
M2 Proton Channel

scholarly journals From Acid Activation Mechanisms of Proton Conduction to Design of Inhibitors of the M2 Proton Channel of Influenza A Virus

2022 ◽  
Vol 8 ◽  
Author(s):  
Elnaz Aledavood ◽  
Beatrice Selmi ◽  
Carolina Estarellas ◽  
Matteo Masetti ◽  
F. Javier Luque
Keyword(s):  
Proton Transport ◽  
Influenza A ◽  
Viral Proteins ◽  
Fusion Peptide ◽  
Proton Channel ◽  
Acid Activation ◽  
Endosomal Membranes ◽  
Activation Mechanisms ◽  
Resistant Strains ◽  
M2 Proton Channel

With an estimated 1 billion people affected across the globe, influenza is one of the most serious health concerns worldwide. Therapeutic treatments have encompassed a number of key functional viral proteins, mainly focused on the M2 proton channel and neuraminidase. This review highlights the efforts spent in targeting the M2 proton channel, which mediates the proton transport toward the interior of the viral particle as a preliminary step leading to the release of the fusion peptide in hemagglutinin and the fusion of the viral and endosomal membranes. Besides the structural and mechanistic aspects of the M2 proton channel, attention is paid to the challenges posed by the development of efficient small molecule inhibitors and the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains.

scholarly journals Proton Transport Mechanism and Pathways in the Superprotonic Phase of M3H(AO4)2 Solid Acids from Ab Initio Molecular Dynamics Simulations

2021 ◽  
Author(s):  
Boris Merinov ◽  
Sergey Morozov
Keyword(s):  
Molecular Dynamics ◽  
Ab Initio ◽  
Proton Transport ◽  
Transport Mechanism ◽  
Solid Acids ◽  
Ab Initio Molecular Dynamics ◽  
Theoretical Studies ◽  
Dynamics Simulations ◽  
Experimental And Theoretical Studies ◽  
Superprotonic Phase

The proton transport mechanism in superprotonic phases of solid acids is a subject of experimental and theoretical studies for a number of years. Despite this, details of the mechanism still...

scholarly journals Functional, Dynamic and Structural Understanding of M2 Proton Channel from Influenza A and its Inhibition

2016 ◽  
Vol 110 (3) ◽  
pp. 192a
Author(s):  
Timothy A. Cross ◽  
Riqiang Fu ◽  
E. Vindana Ekanayake ◽  
Yimin Miao ◽  
Joana Paulino ◽  
...  
Keyword(s):  
Influenza A ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals Designing Inhibitors of M2 Proton Channel against H1N1 Swine Influenza Virus

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9388 ◽  
Author(s):  
Qi-Shi Du ◽  
Ri-Bo Huang ◽  
Shu-Qing Wang ◽  
Kuo-Chen Chou
Keyword(s):  
Influenza Virus ◽  
Swine Influenza Virus ◽  
Swine Influenza ◽  
Proton Channel ◽  
M2 Proton Channel

scholarly journals pH Titration and Acid Activation of the Full-Length Influenza a M2 Proton Channel in Lipid Bilayers

2015 ◽  
Vol 108 (2) ◽  
pp. 246a
Author(s):  
Yimin Miao ◽  
Riqiang Fu ◽  
Huan-Xiang Zhou ◽  
Huajun Qin ◽  
Timothy A. Cross
Keyword(s):  
Lipid Bilayers ◽  
Influenza A ◽  
Full Length ◽  
Proton Channel ◽  
Acid Activation ◽  
Ph Titration ◽  
M2 Proton Channel
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