scholarly journals Structure–Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product

2017 ◽  
Vol 139 (7) ◽  
pp. 2541-2544 ◽  
Author(s):  
Hai L. Tran ◽  
Katrina W. Lexa ◽  
Olivier Julien ◽  
Travis S. Young ◽  
Christopher T. Walsh ◽  
...  
Keyword(s):  
Natural Product ◽  
Molecular Mechanics ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

2020 ◽  
Vol 63 (3) ◽  
pp. 1105-1131 ◽  
Author(s):  
Maryline Kienle ◽  
Patrick Eisenring ◽  
Barbara Stoessel ◽  
Oliver P. Horlacher ◽  
Samuel Hasler ◽  
...  
Keyword(s):  
Natural Product ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

scholarly journals Synthesis and Structure–Activity Relationship Study of NBRI16716B, an Antitumor Natural Product

2015 ◽  
Vol 63 (6) ◽  
pp. 463-468 ◽  
Author(s):  
Hikaru Abe ◽  
Chiharu Sakashita ◽  
Manabu Kawada ◽  
Akio Nomoto ◽  
Takumi Watanabe ◽  
...  
Keyword(s):  
Natural Product ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study

scholarly journals Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

2020 ◽  
Vol 11 (5) ◽  
pp. 1316-1334
Author(s):  
Giambattista Testolin ◽  
Katarina Cirnski ◽  
Katharina Rox ◽  
Hans Prochnow ◽  
Verena Fetz ◽  
...  
Keyword(s):  
Natural Product ◽  
Antibacterial Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
In Vivo Efficacy ◽  
Structure Activity ◽  
Imaging Probes ◽  
Synthetic Studies

Structure–activity relationship studies of the natural product cystobactamid at four different positions led to novel imaging probes and analogs with superior antibacterial activities and in vivo efficacy.

Cover Picture: Structure-Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein (ChemMedChem 11/2017)

ChemMedChem ◽  
2017 ◽  
Vol 12 (11) ◽  
pp. 785-785
Author(s):  
Hang Zhang ◽  
Xiao-Feng Xiong ◽  
Michael W. Boesgaard ◽  
Christina R. Underwood ◽  
Hans Bräuner-Osborne ◽  
...  
Keyword(s):  
Natural Product ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Cyclic Depsipeptide ◽  
Structure Activity

Research Progress on the Natural Product Aloperine and Its Derivatives

2021 ◽  
Vol 21 ◽  
Author(s):  
Yu Cheng ◽  
Abdur Rauf ◽  
Xiandao Pan
Keyword(s):  
Natural Product ◽  
Recent Progress ◽  
Molecular Mechanisms ◽  
Structure Activity Relationship ◽  
Research Progress ◽  
Activity Relationship ◽  
Pharmacological Effects ◽  
Structure Activity ◽  
Relationship Of

: In this review, an effort towards the presentation of an all-around account of the recent progress on the natural product, aloperine is made, and the antivirus structure-activity relationship of its derivatives is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding molecular mechanisms of aloperine are discussed. Some new modification directions of aloperine are given in the end, which might be brief guidance for further investigations on the natural product aloperine.

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