Enantioconvergent Nucleophilic Substitution Reaction of Racemic Alkyne–Dicobalt Complex (Nicholas Reaction) Catalyzed by Chiral Brønsted Acid

2016 ◽  
Vol 138 (34) ◽  
pp. 11038-11043 ◽  
Author(s):  
Masahiro Terada ◽  
Yusuke Ota ◽  
Feng Li ◽  
Yasunori Toda ◽  
Azusa Kondoh
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Nicholas Reaction ◽  
Chiral Bronsted Acid

scholarly journals Chiral Brønsted acid-catalyzed intramolecular SN2′ reaction for enantioselective construction of a quaternary stereogenic center

2018 ◽  
Vol 9 (26) ◽  
pp. 5747-5757 ◽  
Author(s):  
Masahiro Shimizu ◽  
Jun Kikuchi ◽  
Azusa Kondoh ◽  
Masahiro Terada
Keyword(s):  
Substitution Reaction ◽  
Allylic Substitution ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Sn2 Reaction ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Chiral Bronsted Acid ◽  
Stereogenic Center

Construction of a quaternary stereogenic center was accomplished through the enantioselective intramolecular allylic substitution reaction of bis-trichloroacetimidate catalyzed by a chiral phosphoramide derivative.

Brønsted Acid Catalyzed Dehydrative Nucleophilic Substitution of C3-Substituted 2-Indolylmethanols with Azlactones

Synthesis ◽  
2017 ◽  
Vol 50 (02) ◽  
pp. 295-302 ◽  
Author(s):  
Guang-Jian Mei ◽  
Feng Shi ◽  
Chen-Yu Bian ◽  
Dan Li ◽  
Qian Shi
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Direct Synthesis ◽  
Indole Derivatives ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Whole Process ◽  
Brönsted Acid ◽  
New Strategy ◽  
Acid Catalyzed

An efficient dehydrative nucleophilic substitution reaction of C3-substituted2-indolylmethanols with azlactones has been established. In the whole process, Brønsted acid was supposed to activate two substrates simultaneously. A series of structurally diversified indole derivatives were obtained in generally good yields and high diastereoselectivities (up to 86% yield, >95:5 dr). This protocol not only provides a new strategy for the direct synthesis of structurally diversified indole derivatives, but also enriches the chemistry of 2-indolylmethanols via dehydrative substitution reaction.

Practical catalytic enantioselective synthesis of 2,3-dihydroquin-azolinones by chiral brønsted acid catalysis

2021 ◽  
Author(s):  
Yongbiao Guo ◽  
Zhenhua Gao ◽  
Junchen Li ◽  
Xiaojing Bi ◽  
Enxue Shi ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Acid Catalysis ◽  
Enantioselective Synthesis ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Chiral Bronsted Acid ◽  
Bronsted Acid Catalysis

An efficient, practical and scalable protocol to prepare chiral 2,3-dihydroquinazolinones was developed under catalysis of spirocyclic SPINOL-phosphoric acid.

Cooperative Catalysis with Iron and a Chiral Brønsted Acid for Asymmetric Reductive Amination of Ketones

2014 ◽  
Vol 356 (16) ◽  
pp. 3451-3455 ◽  
Author(s):  
Shaolin Zhou ◽  
Steffen Fleischer ◽  
Haijun Jiao ◽  
Kathrin Junge ◽  
Matthias Beller
Keyword(s):  
Reductive Amination ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Cooperative Catalysis ◽  
Brönsted Acid ◽  
Chiral Bronsted Acid

Brønsted Acid-Catalyzed Nucleophilic Substitution of Alcohols

2006 ◽  
Vol 348 (14) ◽  
pp. 1841-1845 ◽  
Author(s):  
Roberto Sanz ◽  
Alberto Martínez ◽  
Delia Miguel ◽  
Julia M. Álvarez-Gutiérrez ◽  
Félix Rodríguez
Keyword(s):  
Nucleophilic Substitution ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Brönsted Acid ◽  
Acid Catalyzed
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