scholarly journals Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450

2015 ◽  
Vol 137 (43) ◽  
pp. 13861-13865 ◽  
Author(s):  
John A. McIntosh ◽  
Thomas Heel ◽  
Andrew R. Buller ◽  
Linda Chio ◽  
Frances H. Arnold
Keyword(s):  
Cytochrome P450 ◽  
Heme Ligation ◽  
Structural Adaptability

scholarly journals Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions

2018 ◽  
Vol 140 (48) ◽  
pp. 16402-16407 ◽  
Author(s):  
Kai Chen ◽  
Shuo-Qing Zhang ◽  
Oliver F. Brandenberg ◽  
Xin Hong ◽  
Frances H. Arnold
Keyword(s):  
Cytochrome P450 ◽  
Transfer Reactions ◽  
Heme Ligation ◽  
Carbene Transfer

scholarly journals Intramolecular Heme Ligation of the Cytochrome P450 2C9 R108H Mutant Demonstrates Pronounced Conformational Flexibility of the B−C Loop Region: Implications for Substrate Binding

Biochemistry ◽  
2010 ◽  
Vol 49 (40) ◽  
pp. 8700-8708 ◽  
Author(s):  
Arthur G. Roberts ◽  
Matthew J. Cheesman ◽  
Andrew Primak ◽  
Michael K. Bowman ◽  
William M. Atkins ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Substrate Binding ◽  
Conformational Flexibility ◽  
Cytochrome P450 2C9 ◽  
Loop Region ◽  
Heme Ligation

Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine

2021 ◽  
Author(s):  
Ansgar Bokel ◽  
Michael C. Hutter ◽  
Vlada B. Urlacher
Keyword(s):  
Cytochrome P450 ◽  
Molecular Evolution ◽  
Cytochrome P450 Monooxygenase ◽  
P450 Monooxygenase ◽  
Effective Synthesis

Engineered cytochrome P450 monooxygenase CYP154E1 enables the effective synthesis of the potential antidepressant (2R,6R)-hydroxynorketamine via N-demethylation and regio- and stereoselective hydroxylation of (R)-ketamine.

Comparison of mechanism-based inhibition of human cytochrome P450 2C19 by ticlopidine, clopidogrel, and prasugrel

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052457079-8
Author(s):  
Y. Nishiya ◽  
K. Hagihara ◽  
A. Kurihara ◽  
N. Okudaira ◽  
N.A. Farid ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Cytochrome ◽  
Cytochrome P450 2C19

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Pharmacogenetics of Clozapine: In Vivo Role of Cytochrome P450 Isoforms and P-Glycoprotein

2008 ◽  
Vol 41 (05) ◽  
Author(s):  
E Jaquenoud-Sirot ◽  
B Knezevic ◽  
G Perla Morena ◽  
P Baumann ◽  
CB Eap
Keyword(s):  
Cytochrome P450 ◽  
P Glycoprotein ◽  
Cytochrome P450 Isoforms
Sign in / Sign up

Export Citation Format

Share Document