scholarly journals New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1

2015 ◽  
Vol 137 (34) ◽  
pp. 10867-10869 ◽  
Author(s):  
David Conradt ◽  
Michael A. Schätzle ◽  
Julian Haas ◽  
Craig A. Townsend ◽  
Michael Müller
Keyword(s):  
Aflatoxin B1 ◽  
Versicolorin A

Biosynthesis of aflatoxin B1. Conversion of versicolorin A to aflatoxin B1 by Aspergillus parasiticus

1976 ◽  
Vol 24 (6) ◽  
pp. 1167-1170 ◽  
Author(s):  
Louise S. Lee ◽  
Joan W. Bennett ◽  
Alva F. Cucullu ◽  
Robert L. Ory
Keyword(s):  
Aflatoxin B1 ◽  
Aspergillus Parasiticus ◽  
Versicolorin A

scholarly journals Versicolorin A enhances the genotoxicity of Aflatoxin B1 in human liver cells by inducing the transactivation of the Ah-Receptor

2021 ◽  
pp. 112258
Author(s):  
Clémence Budin ◽  
Hai-Yen Man ◽  
Carine Al-Ayoubi ◽  
Sylvie Puel ◽  
Barbara M.A. van Vugt-Lussenburg ◽  
...  
Keyword(s):  
Aflatoxin B1 ◽  
Human Liver ◽  
Liver Cells ◽  
Ah Receptor ◽  
Human Liver Cells ◽  
Versicolorin A

HISTOLOGICAL CHANGES IN THE INTESTINES OF POULTRY DURING FODDER INTOXICATION

2020 ◽  
Author(s):  
E.P. Dolgov ◽  
◽  
A.A. Abramov ◽  
E.V. Kuzminova ◽  
E.V. Rogaleva ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Examination ◽  
Aflatoxin B1 ◽  
Structural Changes ◽  
Clinical Manifestations ◽  
Feed Additives ◽  
The Body ◽  
Histological Changes ◽  
Beet Pulp

The article presents the data on the study of the influence of mycotoxins combination (T-2 toxin at the concentration of 0.095 mg/kg and aflatoxin B1 in the concentration of 0.019 mg/kg) on the body of quails and the results of pharmacocorrection of toxicosis with a complex consisting of beet pulp and lecithin. Structural changes in the intestines of quais at fodder mycotoxicosis are described. The use of antitoxic feed additives in poultry led to a weakening of the action of xenobiotics, which was confirmed by an increase in the safety of poultry and increase in body weight of quails, a decrease in the clinical manifestations of intoxication, as well as in positive changes in the structure of the intestine of the poultry during histological examination.

Reduction of Milk Contamination with Aflatoxin-M1 through Vaccination of Dairy Cattle with Aflatoxin-B1 Vaccine

2020 ◽  
Keyword(s):  
Dairy Cattle ◽  
Aflatoxin B1 ◽  
Booster Vaccination ◽  
Primary Vaccination ◽  
Nano Particles ◽  
Aflatoxin M1 ◽  
Serum Samples ◽  
Serum Albumins ◽  
Milk Contamination ◽  
Before And After

Aflatoxin M1 is one of mycotoxin derivatives, which is secreted in milk of dairy cattle fed on feed contaminated with Aflatoxin-B1 (AFB1). The current study was designed to prepare a vaccine against AFB1and to evaluate its efficacy in reducing or preventing secretion of AFM1 in milk. Aflatoxin-B1 was prepared, purified and transformed into oxime, then it was fixed on bovine serum albumins. The AFB1-BSA conjugate was adjuvanted with Gold Nano particles then Montanide ISA 206. The prepared vaccine was used for immunization of rabbits by S/c routes as 100 µg/dose and dairy cattle by I/M routes as 500 µg/dose. The vaccinated animals were boosted at 3 weeks post primary immunization. Serum samples were collected and examined for the anti-AFB1 using AGPT. A mean titer of 15.2 AGPU/ml was detected at 2 weeks post primary vaccination then significantly increased till reached to 76.8 AGPU/ml at 6 weeks post Booster vaccination. All vaccinated rabbits were challenged with dose of 0.3 mg AFB1 toxin/Kg. The vaccinated rabbit showed 100% protection and no AFB1 toxin residue was detected in their livers. Milk samples were collected from non-vaccinated and AFB1-immunized dairy cattle then examined with ELISA for quantitation of AFM1 residues before and after vaccination. The results showed that the prepared AFB1 vaccine was safe, potent and able to reduce AFM1 release in milk of vaccinated heifers by 70%. So the vaccination of lactating animals with the AFB1vaccine might represent a valid tool for the prevention of AFM1 contamination of milk and dairy products.

Sign in / Sign up

Export Citation Format

Share Document