PEGylated N-Heterocyclic Carbene Anchors Designed To Stabilize Gold Nanoparticles in Biologically Relevant Media

2015 ◽  
Vol 137 (25) ◽  
pp. 7974-7977 ◽  
Author(s):  
Michelle J. MacLeod ◽  
Jeremiah A. Johnson
Keyword(s):  
Gold Nanoparticles ◽  
Biologically Relevant

Using selenium-conjugated polyethylene glycol to enhance the stability of gold nanoparticles in biologically relevant samples

2018 ◽  
Vol 62 (2) ◽  
pp. 280-286 ◽  
Author(s):  
Yang Xue ◽  
Bo Dong ◽  
Xuehui Liu ◽  
Fengchao Wang ◽  
Jie Yang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Polyethylene Glycol ◽  
Biologically Relevant ◽  
The Stability

Cells Undergo Major Changes in the Quantity of Cytoplasmic Organelles after Uptake of Gold Nanoparticles with Biologically Relevant Surface Coatings

ACS Nano ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 2248-2264 ◽  
Author(s):  
Burcu Kepsutlu ◽  
Virginia Wycisk ◽  
Katharina Achazi ◽  
Sergey Kapishnikov ◽  
Ana Joaquina Pérez-Berná ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Surface Coatings ◽  
Biologically Relevant ◽  
Cytoplasmic Organelles

PEGylated gold nanoparticles promoted rapid macromolecular chain-end transformation and formation of injectable hydrogels

2020 ◽  
Vol 8 (3) ◽  
pp. 465-477 ◽  
Author(s):  
Bhingaradiya Nutan ◽  
Suresh K. Jewrajka
Keyword(s):  
Gold Nanoparticles ◽  
Michael Addition ◽  
Addition Reactions ◽  
Injectable Hydrogels ◽  
Au Nps ◽  
Biologically Relevant ◽  
Macromolecular Chain ◽  
Grafting Density ◽  
Rapid Formation

Highly stable PEGylated Au NPs with low grafting density exhibit significant effect towards azide–alkyne click cycloaddition and Michael addition reactions leading to rapid formation of injectable hydrogels and biologically relevant macromolecules.

scholarly journals Chemiresistive/SERS dual sensor based on densely packed gold nanoparticles

2015 ◽  
Vol 6 ◽  
pp. 2498-2503 ◽  
Author(s):  
Sanda Boca ◽  
Cosmin Leordean ◽  
Simion Astilean ◽  
Cosmin Farcau
Keyword(s):  
Gold Nanoparticles ◽  
Electron Tunneling ◽  
Building Blocks ◽  
Biologically Relevant ◽  
Self Assembling ◽  
Dual Sensor ◽  
Surface Enhanced Raman ◽  
Common Principle ◽  
Enhanced Raman Scattering ◽  
Optically Detected

Chemiresistors are a class of sensitive electrical devices capable of detecting (bio)chemicals by simply monitoring electrical resistance. Sensing based on surface enhanced Raman scattering (SERS) represents a radically different approach, in which molecules are optically detected according to their vibrational spectroscopic fingerprint. Despite different concepts are involved, one can find in the literature examples from both categories reporting sensors made of gold nanoparticles. The same building blocks appear because both sensor classes share a common principle: nanometric interparticle gaps are needed, for electron tunneling in chemiresistors, and for enhancing electromagnetic fields by plasmon coupling in SERS-based sensors. By exploiting such nano-gaps in self-assembled films of gold nanoparticles, we demonstrate the proof of concept of a dual electrical/optical sensor, with both chemiresistive and SERS capabilities. The proposed device is realized by self-assembling 15 nm gold nanoparticles into few micrometers-wide strips across commercially available interdigitated electrodes. The dual-mode operation of the device is demonstrated by the detection of a biologically relevant model analyte, 4-mercaptophenyl boronic acid.

scholarly journals GOLD NANOPARTICLES ENCAPSULATED IN A POLYMERIC MATRIX OF SODIUM ALGINATE

2016 ◽  
Vol 73 (2) ◽  
pp. 134
Author(s):  
Oana Lelia POP ◽  
Loredana Florina LEOPOLD ◽  
Olivia Dumitrita RUGINA ◽  
Zortia DIACONEASA ◽  
Ioana OPREA ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Confocal Microscopy ◽  
Sodium Alginate ◽  
Spherical Shape ◽  
Building Blocks ◽  
In Vitro Cytotoxicity ◽  
In Vitro Tests ◽  
Biologically Relevant ◽  
Cell Functions

Plasmonic nanoparticles can be used as building blocks for the design of multifunctional systems based on polymeric capsules. The use of functionalised particles in therapeutics and imaging and understanding their effect on the cell functions are among the current challenges in nanobiotechnology and nanomedicine. The aim of the study was to manufacture and characterize polymeric microstructures by encapsulating plasmonic gold nanoparticles in biocompatible matrix of sodium alginate. The gold nanoparticles were obtained by reduction of tetracluoroauric acid with sodium citrate. To characterize the microcapsules, UV-Vis and FTIR spectroscopy, optical and confocal microscopy experiments were performed. In vitro cytotoxicity tests on HFL-1 cells were also performed. The capsules have spherical shape and 120 μm diameter. The presence of encapsulated gold nanoparticles is also shown by confocal microscopy. In vitro tests show that the microcapsules are not cytotoxic upon 24 h of cells exposure to microcapsules concentrations ranging from 2.5 to 25 capsules per cell. The obtained microcapsules of sodium alginate loaded with plasmonic gold nanoparticles could potentially be considered as release systems for biologically relevant molecules.

Gold nanoparticle-based sensing strategies for biomolecular detection

2010 ◽  
Vol 82 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Lihua Wang ◽  
Shiping Song ◽  
Dun Pan ◽  
Di Li ◽  
Chunhai Fan
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Small Molecule ◽  
Recent Progress ◽  
Short Review ◽  
Biological Detection ◽  
Biomolecular Detection ◽  
Biologically Relevant ◽  
Biological Studies ◽  
Optical And Electronic Properties

Gold nanoparticles (AuNPs) have been extensively employed in biological studies for several decades. More recently, progress has well demonstrated that DNA-conjugated AuNPs are highly promising nanoprobes for the sensitive detection of various biomolecules, based on the unique optical and electronic properties of AuNPs. In this short review, we focus on the use of AuNP-based nanoprobes for biological detection of nucleic acids, proteins, and other biologically relevant small-molecule targets, mainly based on the recent progress in our laboratory.

Investigation of thin sections of biological standards by EDX, EELS, and Auger electron spectroscopy

1990 ◽  
Vol 48 (2) ◽  
pp. 184-185
Author(s):  
S. Lehner ◽  
H.E. Bauer ◽  
R. Wurster ◽  
H. Seiler
Keyword(s):  
Processing System ◽  
Beam Current ◽  
Beam Diameter ◽  
Thin Sections ◽  
Biologically Relevant ◽  
Energy Filtering ◽  
Low Viscosity ◽  
Carbon Foils ◽  
Electron Microscopical ◽  
Exchange Membrane

In order to compare different microanalytical techniques commercially available cation exchange membrane SC-1 (Stantech Inc, Palo Alto), was loaded with biologically relevant elements as Na, Mg, K, and Ca, respectively, each to its highest possible concentration, given by the number concentration of exchangeable binding sites (4 % wt. for Ca). Washing in distilled water, dehydration through a graded series of ethanol, infiltration and embedding in Spurr’s low viscosity epoxy resin was followed by thin sectioning. The thin sections (thickness of about 50 nm) were prepared on carbon foils and mounted on electron microscopical finder grids.The samples were analyzed with electron microprobe JXA 50A with transmitted electron device, EDX system TN 5400, and on line operating image processing system SEM-IPS, energy filtering electron microscope CEM 902 with EELS/ESI and Auger spectrometer 545 Perkin Elmer.With EDX, a beam current of some 10-10 A and a beam diameter of about 10 nm, a minimum-detectable mass of 10-20 g Ca seems within reach.

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