Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

Masaki Horitani; Amanda S. Byer; Krista A. Shisler; Tilak Chandra; Joan B. Broderick; Brian M. Hoffman

doi:10.1021/jacs.5b00498

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

Journal of the American Chemical Society ◽

10.1021/jacs.5b00498 ◽

2015 ◽

Vol 137 (22) ◽

pp. 7111-7121 ◽

Cited By ~ 37

Author(s):

Masaki Horitani ◽

Amanda S. Byer ◽

Krista A. Shisler ◽

Tilak Chandra ◽

Joan B. Broderick ◽

...

Keyword(s):

Free Radical ◽

Double Resonance ◽

Electron Nuclear Double Resonance ◽

Radical Sam ◽

Radical Sam Enzymes

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Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Studies of X-Irradiated Crystals of Cytosine Hydrochloride. Part I: Free Radical Formation at 10 K after High Radiation Doses

Radiation Research ◽

10.2307/3579919 ◽

1998 ◽

Vol 149 (2) ◽

pp. 109 ◽

Cited By ~ 15

Author(s):

Eli O. Hole ◽

William H. Nelson ◽

Einar Sagstuen ◽

David M. Close

Keyword(s):

Electron Paramagnetic Resonance ◽

Free Radical ◽

Double Resonance ◽

Radical Formation ◽

Radiation Doses ◽

High Radiation ◽

Electron Nuclear Double Resonance ◽

Paramagnetic Resonance ◽

Free Radical Formation ◽

Electron Paramagnetic

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Electron nuclear double resonance of bacteriochlorophyll free radical in vitro and in vivo

Journal of the American Chemical Society ◽

10.1021/ja00786a066 ◽

1973 ◽

Vol 95 (5) ◽

pp. 1680-1682 ◽

Cited By ~ 94

Author(s):

James R. Norris ◽

Mary Ellen. Druyan ◽

Joseph J. Katz

Keyword(s):

Free Radical ◽

Double Resonance ◽

Electron Nuclear Double Resonance

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Evaluation and assignment of proton and nitrogen hyperfine coupling constants in the free-radical 1-picryl-2,2-diphenylhydrazyl. An NMR, electron-nuclear double resonance, and electron-nuclear-nuclear triple resonance study

The Journal of Physical Chemistry ◽

10.1021/j100489a027 ◽

1979 ◽

Vol 83 (26) ◽

pp. 3449-3456 ◽

Cited By ~ 21

Author(s):

Reinhard. Biehl ◽

Klaus. Moebius ◽

Sally E. O'Connor ◽

Robert I. Walter ◽

Herbert. Zimmermann

Keyword(s):

Free Radical ◽

Hyperfine Coupling ◽

Double Resonance ◽

Coupling Constants ◽

Triple Resonance ◽

Electron Nuclear Double Resonance ◽

Hyperfine Coupling Constants

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Electron-nuclear double resonance of the hydrogen peroxide compound of cytochrome c peroxidase: identification of the free radical site with a methionyl cluster.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.76.12.6132 ◽

1979 ◽

Vol 76 (12) ◽

pp. 6132-6136 ◽

Cited By ~ 54

Author(s):

B. M. Hoffman ◽

J. E. Roberts ◽

T. G. Brown ◽

C. H. Kang ◽

E. Margoliash

Keyword(s):

Hydrogen Peroxide ◽

Free Radical ◽

Cytochrome C ◽

Double Resonance ◽

Cytochrome C Peroxidase ◽

Electron Nuclear Double Resonance ◽

Radical Site ◽

Peroxide Compound

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ChemInform Abstract: EVALUATION AND ASSIGNMENT OF PROTON AND NITROGEN HYPERFINE COUPLING CONSTANTS IN THE FREE-RADICAL 1-PICRYL-2,2-DIPHENYLHYDRAZYL. AN NMR, ELECTRON-NUCLEAR DOUBLE RESONANCE, AND ELECTRON-NUCLEAR-NUCLEAR TRIPLE RESONANCE STUDY

Chemischer Informationsdienst ◽

10.1002/chin.198014057 ◽

1980 ◽

Vol 11 (14) ◽

Author(s):

R. BIEHL ◽

K. MOEBIUS ◽

S. E. O'CONNOR ◽

R. I. WALTER ◽

H. ZIMMERMANN

Keyword(s):

Free Radical ◽

Hyperfine Coupling ◽

Double Resonance ◽

Coupling Constants ◽

Triple Resonance ◽

Electron Nuclear Double Resonance ◽

Hyperfine Coupling Constants

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Free Radical Formation in Single Crystals of 9-Methyladenine X-Irradiated at 10 K. An Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Study

Radiation Research ◽

10.2307/3578944 ◽

1995 ◽

Vol 144 (3) ◽

pp. 258 ◽

Cited By ~ 5

Author(s):

Eli O. Hole ◽

Einar Sagstuen ◽

William H. Nelson ◽

David M. Close

Keyword(s):

Electron Paramagnetic Resonance ◽

Free Radical ◽

Single Crystals ◽

Double Resonance ◽

Radical Formation ◽

Electron Nuclear Double Resonance ◽

Paramagnetic Resonance ◽

Free Radical Formation ◽

Electron Paramagnetic

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Radical SAM Enzymes

10.1016/s0076-6879(18)x0008-1 ◽

2018 ◽

Keyword(s):

Radical Sam ◽

Radical Sam Enzymes

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Electron-nuclear double resonance of impurity centers in nonmetallic crystals

Uspekhi Fizicheskih Nauk ◽

10.3367/ufnr.0125.197808b.0631 ◽

1978 ◽

Vol 125 (8) ◽

pp. 631-663 ◽

Cited By ~ 13

Author(s):

B.G. Grachev ◽

M.F. Deigen

Keyword(s):

Double Resonance ◽

Electron Nuclear Double Resonance ◽

Impurity Centers

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Faculty Opinions recommendation of Anaerobic sulfatase-maturating enzymes: radical SAM enzymes able to catalyze in vitro sulfatase post-translational modification.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1072057.525038 ◽

2007 ◽

Author(s):

Joan Broderick

Keyword(s):

Post Translational Modification ◽

Radical Sam ◽

Radical Sam Enzymes

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Faculty Opinions recommendation of Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717960468.793471870 ◽

2013 ◽

Author(s):

E Neil G Marsh ◽

Gabriel Román-Meléndez

Keyword(s):

Radical Sam ◽

Radical Sam Enzymes

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