Total Synthesis of Dalesconol A by Pd(0)/Norbornene-Catalyzed Three-Fold Domino Reaction and Pd(II)-Catalyzed Trihydroxylation

Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction

Angewandte Chemie International Edition ◽

10.1002/anie.201209868 ◽

2013 ◽

Vol 52 (11) ◽

pp. 3191-3194 ◽

Cited By ~ 37

Author(s):

Lutz F. Tietze ◽

Svenia-C. Duefert ◽

Jérôme Clerc ◽

Matthias Bischoff ◽

Christian Maaß ◽

...

Keyword(s):

Total Synthesis ◽

Domino Reaction ◽

Palladium Catalyzed

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Total Synthesis of Cyclopiamide A Using Palladium-Catalyzed Domino Cyclization

Molecules ◽

10.3390/molecules25214903 ◽

2020 ◽

Vol 25 (21) ◽

pp. 4903

Author(s):

Sunhwa Park ◽

Kye Jung Shin ◽

Jae Hong Seo

Keyword(s):

Total Synthesis ◽

Domino Reaction ◽

Palladium Catalyzed ◽

One Step

Total synthesis of cyclopiamide A was accomplished using a palladium-catalyzed domino cyclization. Three rings in the tetracyclic skeleton of cyclopiamide A were constructed in a one-step domino reaction incorporating double carbopalladation and C-H activation.

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Total Synthesis of Linoxepin through a Palladium-Catalyzed Domino Reaction

Angewandte Chemie ◽

10.1002/ange.201209868 ◽

2013 ◽

Vol 125 (11) ◽

pp. 3273-3276 ◽

Cited By ~ 17

Author(s):

Lutz F. Tietze ◽

Svenia-C. Duefert ◽

Jérôme Clerc ◽

Matthias Bischoff ◽

Christian Maaß ◽

...

Keyword(s):

Total Synthesis ◽

Domino Reaction ◽

Palladium Catalyzed

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A Concise Total Synthesis of (±)-Camptothecin

Synthesis ◽

10.1055/s-0037-1611870 ◽

2019 ◽

Vol 51 (18) ◽

pp. 3506-3510

Author(s):

Qian Liu ◽

Guan-xin Huang ◽

Min-jie Liu ◽

Fen-Er Chen

Keyword(s):

Total Synthesis ◽

Michael Addition ◽

Heck Reaction ◽

Hydrobromic Acid ◽

Functional Group ◽

Domino Reaction ◽

One Pot ◽

Protective Groups ◽

Efficient Scheme ◽

Functional Group Transformation

A total synthesis of racemic camptothecin, characterized by a concise construction of the ring systems and easy functional group transformation, is described. A domino reaction consisting of a Heck reaction and an aza-intramolecular Michael addition to form the C ring serves as the first key step in the synthesis. The D ring was constructed by a simple Wittig–Horner reaction followed by removal of the protective groups. Hydroxymethylation, demethylation, and lactone formation reactions were performed in one-pot to construct the E ring under hydrobromic acid conditions. This work provides an efficient scheme for further synthetic exploration of camptothecin and its analogues.

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A Simple Synthesis of Densely Substituted Benzofurans by Domino Reaction of 2-Hydroxybenzyl Alcohols with 2-Substituted Furans

Synthesis ◽

10.1055/s-0039-1690000 ◽

2019 ◽

Vol 51 (19) ◽

pp. 3747-3757 ◽

Cited By ~ 2

Author(s):

Anton S. Makarov ◽

Anna E. Kekhvaeva ◽

Petrakis N. Chalikidi ◽

Vladimir T. Abaev ◽

Igor V. Trushkov ◽

...

Keyword(s):

Total Synthesis ◽

Intermediate Formation ◽

Simple Synthesis ◽

Domino Reaction ◽

Acid Catalyzed ◽

Substituted Furans

The Brönsted acid-catalyzed cascade synthesis of densely substituted benzofurans from easily available salicyl alcohols and biomass-derived furans has been developed. The disclosed sequence includes the intermediate formation of 2-(2-hydroxybenzyl)furans that quickly rearrange into functionalized benzofurans. The established protocol was applied for the total synthesis of sugikurojinol B.

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