Controlling Localized Plasmons via an Atomistic Approach: Attainment of Site-Selective Activation inside a Single Molecule

2022 ◽  
Author(s):  
Sayantan Mahapatra ◽  
Jeremy F. Schultz ◽  
Linfei Li ◽  
Xu Zhang ◽  
Nan Jiang
Keyword(s):  
Single Molecule ◽  
Selective Activation ◽  
Localized Plasmons ◽  
Site Selective

Metal-free amino-controlled electrochemical intramolecular C–O and C–N couplings by site-selective activation of aryl C–N and C–O bonds

2021 ◽  
Author(s):  
Mu-Jia Luo ◽  
Gui-Fen Lv ◽  
Yang Li ◽  
Jin-Heng Li
Keyword(s):  
Free Amino ◽  
Selective Activation ◽  
Metal Free ◽  
Site Selective

Metal-free amino-assisted electrochemical intramolecular C–O or C–N couplings of amino-2-(2-aminoaryl)phenols are described.

scholarly journals Photoredox Catalyzed Site-Selective Generation of Carbanions from C(sp3)-H bonds in Amines

2021 ◽  
Author(s):  
Kathiravan Murugesan ◽  
Karsten Donabauer ◽  
Rok Narobe ◽  
Armin Bauer ◽  
Volker Derdau ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Late Stage ◽  
Carbonyl Compounds ◽  
Chemical Research ◽  
Selective Activation ◽  
Mechanistic Investigation ◽  
Specific Position ◽  
Selective Generation ◽  
Carbon Hydrogen Bonds ◽  
Site Selective

The selective activation of sp3 carbon-hydrogen bonds in presence of multiple C¬-H bonds is challenging and remains of supreme importance in chemical research. Herein, we describe the activation of a C(sp3) H bond in α position to an amine via a carbanion intermediate. In the presence of several α amine sites, only one specific position is selectively activated. Applying this protocol, the proposed carbanion intermediate was effectively trapped with different electrophiles such as deuterium (D+), tritium (T+), or carbonyl compounds compiling over 50 examples. Further, this methodology was used to install deuterium or tritium in different drug derivatives (> 10 drugs) at a selected position in a late-stage functionalization. In addition, the protocol is suitable for a gram-scale synthesis and a detailed mechanistic investigation has been carried out to support our hypothesis.

A highly acidic acridine for efficient site-selective activation of RNA leading to an eminent ribozyme mimic

2002 ◽  
Vol 43 (46) ◽  
pp. 8249-8252 ◽  
Author(s):  
Akinori Kuzuya ◽  
Kenzo Machida ◽  
Makoto Komiyama
Keyword(s):  
Selective Activation ◽  
Site Selective ◽  
Ribozyme Mimic

Stereochemically Pure Acridine-modified DNA for Site-selective Activation and Scission of RNA

2003 ◽  
Vol 32 (5) ◽  
pp. 464-465 ◽  
Author(s):  
Yun Shi ◽  
Akinori Kuzuya ◽  
Makoto Komiyama
Keyword(s):  
Selective Activation ◽  
Modified Dna ◽  
Site Selective

Site-Selective Activation of RNA Leading to Sequence-Selective RNA Cutters

2002 ◽  
Vol 75 (12) ◽  
pp. 2547-2554 ◽  
Author(s):  
Makoto Komiyama ◽  
Akinori Kuzuya ◽  
Ryo Mizoguchi
Keyword(s):  
Selective Activation ◽  
Site Selective
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