Pd/GF-Phos-Catalyzed Asymmetric Three-Component Coupling Reaction to Access Chiral Diarylmethyl Alkynes

Palladium-Catalyzed Three-Component Coupling Reaction of Benzyl Chlorides, Allyltributylstannane, and Carbon Monoxide: Efficient Synthesis of α,β-Unsaturated Ketones

CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) ◽

10.3724/sp.j.1088.2012.10930 ◽

2013 ◽

Vol 33 (3) ◽

pp. 523-529

Author(s):

Xin ZHANG ◽

Xiujuan FENG ◽

Hesong LIU ◽

Yuhu QIN ◽

Yao DAI

Keyword(s):

Carbon Monoxide ◽

Coupling Reaction ◽

Efficient Synthesis ◽

Unsaturated Ketones ◽

Benzyl Chlorides ◽

Palladium Catalyzed ◽

Three Component Coupling

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N-Alkylation/aldol reaction of α-aldimino thioesters: a facile three-component coupling reaction

RSC Advances ◽

10.1039/d1ra02000e ◽

2021 ◽

Vol 11 (22) ◽

pp. 13097-13104

Author(s):

Makoto Shimizu ◽

Asako Higashino ◽

Isao Mizota ◽

Yusong Zhu

Keyword(s):

Aldol Reaction ◽

Coupling Reaction ◽

Three Component Coupling

Treatment of α-aldimino thioesters with dialkylzinc reagents in the presence of aldehydes or imines gives three-component coupling products in good yields with good to high anti-selectivities.

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PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.7.157 ◽

2011 ◽

Vol 7 ◽

pp. 1334-1341 ◽

Cited By ~ 29

Author(s):

Sanny Verma ◽

Suman L Jain ◽

Bir Sain

Keyword(s):

Coupling Reaction ◽

Recyclable Catalyst ◽

Efficient Synthesis ◽

Molecular Bromine ◽

Keto Ester ◽

One Step ◽

High Yields ◽

Multicomponent Coupling ◽

Three Component Coupling

PEG-embedded potassium tribromide ([K+PEG]Br3 −) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester. At the end of the reaction the [K+PEG]Br3 − was readily regenerated from the reaction mixture by treating the residue containing [K+PEG]Br− with molecular bromine.

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