Uniting Amide Synthesis and Activation by PIII/PV–Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines

2021 ◽  
Author(s):  
Jeffrey M. Lipshultz ◽  
Alexander T. Radosevich
Keyword(s):  
Amide Synthesis ◽  
Component Assembly

scholarly journals Discovery, characterization and engineering of ligases for amide synthesis

Nature ◽  
2021 ◽  
Vol 593 (7859) ◽  
pp. 391-398
Author(s):  
Michael Winn ◽  
Michael Rowlinson ◽  
Fanghua Wang ◽  
Luis Bering ◽  
Daniel Francis ◽  
...  
Keyword(s):  
Amide Synthesis

The Influence of Manufacturing Tolerances on Swirler Durability

2014 ◽  
Author(s):  
Nagaraja S. Rudrapatna ◽  
Richard R. Bohman ◽  
Jonathan K. Anderson ◽  
Rudolph Dudebout ◽  
Richard Hausen
Keyword(s):  
Damage Mechanism ◽  
Jet Fuel ◽  
Combustible Mixture ◽  
Fuel Injector ◽  
Component Level ◽  
Pareto Chart ◽  
Flow Features ◽  
Manufacturing Tolerances ◽  
Oxidation Damage ◽  
Component Assembly

Jet fuel flowing through the fuel injector is atomized and then mixed with high temperature compressed air flowing through the swirler to create a combustible mixture inside a gas turbine combustor. Individual geometric and flow features are carefully tuned at a component level to deliver optimum combustion performance. In a critical interface such as the fuel injector and swirler, manufacturing tolerances not only have an impact on combustor performance and operability but also on durability, as the relative position of the fuel injector to the swirler significantly impacts the swirler temperature. This paper studies the influence of manufacturing tolerances on component assembly and the resulting impact on swirler temperature. The oxidation damage mechanism of the swirler is used as a measure to assess swirler durability. A Pareto chart of the effect of manufacturing tolerances on metal temperature is used to highlight the key influencing parameters. Probability distribution associated with manufacturing tolerances is gathered with Monte Carlo simulation to guide the design.

scholarly journals Shock Pulse Shaping in a Small-Form Factor Velocity Amplifier

2010 ◽  
Vol 17 (6) ◽  
pp. 787-802 ◽  
Author(s):  
Gerard Kelly ◽  
Jeff Punch ◽  
Suresh Goyal ◽  
Michael Sheehy
Keyword(s):  
Pulse Shaping ◽  
Vertical Axis ◽  
Mechanical Shock ◽  
Practical Applications ◽  
Shock Testing ◽  
Acceleration Signal ◽  
High Acceleration ◽  
Component Assembly ◽  
Small Form Factor ◽  
Shock Pulses

This theme of this paper is the design and characterisation of a velocity amplifier (VAMP) machine for high-acceleration shock testing of micro-scale devices. The VAMP applies multiple sequential impacts to amplify velocity through a system of three progressively smaller masses constrained to move in the vertical axis. Repeatable, controlled, mechanical shock pulses are created through the metal-on-metal impact between pulse shaping test rods, which form part of the penultimate and ultimate masses. The objectives are to investigate the controllable parameters that affect the shock pulses induced on collision, namely; striker and incident test rod material; test rod length; pulse shaping mechanisms; and impact velocity. The optimum VAMP configuration was established as a 60 mm long titanium striker test rod and a 120 mm long titanium incident rod. This configuration exhibited an acceleration magnitude and a primary pulse duration range of 5,800–23,400 g and 28.0–44.0μs respectively. It was illustrated that the acceleration spectral content can be manipulated through control of the test rod material and length. This is critical in the context of practical applications, where it is postulated that the acceleration signal can be controlled to effectively excite specific components in a multi-component assembly affixed to the VAMP incident test rod.

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