Anchorage-Dependent Living Supramolecular Self-Assembly of Polymeric Micelles

2021 ◽  
Author(s):  
Zhengmin Tang ◽  
Liang Gao ◽  
Jiaping Lin ◽  
Chunhua Cai ◽  
Yuan Yao ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles

scholarly journals Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Caio H. N. Barros ◽  
Dishon W. Hiebner ◽  
Stephanie Fulaz ◽  
Stefania Vitale ◽  
Laura Quinn ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Self Assembly ◽  
Glycolic Acid ◽  
Extracellular Polymeric Substances ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Enhanced Resistance ◽  
Antimicrobial Nanoparticles ◽  
Good Penetration ◽  
Antibiofilm Agents

Abstract Background The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategies must take into account the existence of extracellular polymeric substances, which obstruct the diffusion of antibiofilm agents and assists in the maintenance of a well-defended microbial community. Within this context, nanoparticles have been studied for their drug delivery efficacy and easily customised surface. Nevertheless, there usually is a requirement for nanocarriers to be used in association with an antimicrobial agent; the intrinsically antimicrobial nanoparticles are most often made of metals or metal oxides, which is not ideal from ecological and biomedical perspectives. Based on this, the use of polymeric micelles as nanocarriers is appealing as they can be easily prepared using biodegradable organic materials. Results In the present work, micelles comprised of poly(lactic-co-glycolic acid) and dextran are prepared and then functionalised with curcumin. The effect of the functionalisation in the micelle’s physical properties was elucidated, and the antibacterial and antibiofilm activities were assessed for the prepared polymeric nanoparticles against Pseudomonas spp. cells and biofilms. It was found that the nanoparticles have good penetration into the biofilms, which resulted in enhanced antibacterial activity of the conjugated micelles when compared to free curcumin. Furthermore, the curcumin-functionalised micelles were efficient at disrupting mature biofilms and demonstrated antibacterial activity towards biofilm-embedded cells. Conclusion Curcumin-functionalised poly(lactic-co-glycolic acid)-dextran micelles are novel nanostructures with an intrinsic antibacterial activity tested against two Pseudomonas spp. strains that have the potential to be further exploited to deliver a secondary bioactive molecule within its core. Graphic Abstract

Artificial Cellulosome Complex from the Self‐Assembly of Ni‐NTA‐Functionalized Polymeric Micelles and Cellulases

ChemBioChem ◽  
2019 ◽  
Vol 20 (11) ◽  
pp. 1394-1399 ◽  
Author(s):  
Lin Lu ◽  
Libo Zhang ◽  
Liang Yuan ◽  
Tianyu Zhu ◽  
Wilfred Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles ◽  
The Self

Novel biocompatible fluorescent polymeric micelles based on 1,8-naphthalimide derivatives for cell imaging

2015 ◽  
Vol 6 (3) ◽  
pp. 364-368 ◽  
Author(s):  
Bei-Yu Liu ◽  
Wan-Xia Wu ◽  
Na Wang ◽  
Xiao-Qi Yu
Keyword(s):  
Self Assembly ◽  
Cell Imaging ◽  
Polymeric Micelles ◽  
Ph Sensor ◽  
Polymeric Micelle ◽  
Living Cells ◽  
Amphiphilic Block Copolymers ◽  
Good Potential ◽  
New Type ◽  
Good Biocompatibility

A new type of fluorescent polymeric micelle was developed by the aqueous self-assembly from amphiphilic block copolymers via click chemistry and showed good potential for application in cell imaging with good biocompatibility. Notably, P1 can readily serve as an excellent intracellular pH sensor in whole living cells based on PET inhibition

Chaotropic-Anion-Induced Supramolecular Self-Assembly of Ionic Polymeric Micelles

2014 ◽  
Vol 126 (31) ◽  
pp. 8212-8216 ◽  
Author(s):  
Yang Li ◽  
Yiguang Wang ◽  
Gang Huang ◽  
Xinpeng Ma ◽  
Kejin Zhou ◽  
...  
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles

Effect of Tail Architecture on Self-Assembly of Amphiphiles for Polymeric Micelles

Langmuir ◽  
2009 ◽  
Vol 25 (5) ◽  
pp. 2749-2756 ◽  
Author(s):  
Lisheng Cheng ◽  
Dapeng Cao
Keyword(s):  
Self Assembly ◽  
Polymeric Micelles

Enzyme-responsive polymeric micelles with fluorescence fabricated through aggregation-induced copolymer self-assembly for anticancer drug delivery

2020 ◽  
Vol 11 (48) ◽  
pp. 7704-7713
Author(s):  
Ke Yan ◽  
Shujing Zhang ◽  
Kun Zhang ◽  
Yalei Miao ◽  
Yudian Qiu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Polymeric Micelle ◽  
Anticancer Drug Delivery ◽  
Hydrophobic Chain

The TPE moiety with AIE is employed as functional hydrophobic chain to induce copolymer self-assembly and form polymeric micelle that can show enzyme-responsive drug delivery.

scholarly journals Effect of Molecular Weight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Hojjat Sadeghi ◽  
Farzin Firozian ◽  
Mina Mirian
Keyword(s):  
Molecular Weight ◽  
Particle Size ◽  
Zeta Potential ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Molar Ratio ◽  
Loading Capacity ◽  
Hydrophobic Polymers ◽  
Polymer Surfactants

Amphiphilic polymer surfactants are composed of hydrophilic and hydrophobic polymers and are widely used in targeted drug delivery. The purpose of this study was the evaluation of the effect of molecular weight and molar ratio of dextran on physicochemical properties of dextran stearate polymeric micelles. Dextran stearate was synthesized by acylation of dextran with stearoyl chloride. Etoposide loaded polymeric micelles were prepared by dialysis method. The resulting micelles were evaluated for particle size, zeta potential, critical micelle concentration (CMC), drug loading capacity, and release efficiency. Cytotoxicity and cellular uptake of micelles were studied in CT-26 colorectal carcinoma cell line. Molecular weight and molar ratio of dextran-stearate were impressive on zeta potential, CMC, drug loading capacity, and release efficiency. Unlike polymer molecular weight, molar ratio of stearate had a significant effect on cytotoxicity and particle size of etoposide loaded micelles. Although molecular weight of dextran had no significant effect on cytotoxicity of micelles on CT-26 cells, it had drastic attributes for stability of polymeric micelles. Consequently, both variables of molecular weight of dextran and molar ratio of stearate should be taken into account to have a stable and effective micelle of dextran-stearate.

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