Asymmetric Radical Process for General Synthesis of Chiral Heteroaryl Cyclopropanes

2021 ◽  
Author(s):  
Xiaoxu Wang ◽  
Jing Ke ◽  
Yiling Zhu ◽  
Arghya Deb ◽  
Yijie Xu ◽  
...  
Keyword(s):  
Radical Process ◽  
General Synthesis

A Short Synthesis of (+)-Brefeldin C via Enantioselective Radical Hydroalkynylation

2019 ◽  
Author(s):  
Lars Gnägi ◽  
Severin Vital Martz ◽  
Daniel Meyer ◽  
Robin Marc Schärer ◽  
Philippe Renaud
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Oxidation State ◽  
Single Step ◽  
Radical Process ◽  
Target Molecule ◽  
Short Synthesis ◽  
The One

<div><div><div><div><p>A very concise total synthesis of (+)-brefeldin C starting from 2-furanylcyclopentene is described. This approach is based on an unprecedented enantioselective radical hydroalkynylation process to introduce the two cyclopentane stereocenters in a single step. The use of a furan substituent allows to achieve a high trans diastereoselectivity during the radical process and it contains the four carbon atoms C1–C4 of the natural product in an oxidation state closely related to the one of the target molecule. The eight-step synthesis require six product purifications and it provides (+)-brefeldin C in 18% overall yield.</p></div></div></div></div>

Generation of (E)-β-sulfonyl enamines from sulfur dioxide via a radical process

2021 ◽  
Vol 8 (8) ◽  
pp. 1789-1794
Author(s):  
Xiaodong Tu ◽  
Jiapian Huang ◽  
Wenlin Xie ◽  
Tonghao Zhu ◽  
Jie Wu
Keyword(s):  
Sulfur Dioxide ◽  
Radical Process ◽  
Three Component Reaction

An iron(ii)-catalyzed three-component reaction of O-acyl oximes, sulfur dioxide, and N-vinylacetamides is accomplished. Diverse (E)-β-sulfonyl enamines are obtained in moderate to good yields by using this protocol with excellent stereoselectivity and regioselectivity.

General Synthesis of Ordered Mesoporous Carbonaceous Hybrid Nanostructures with Molecularly Dispersed Polyoxometallates

2021 ◽  
Author(s):  
Chaoliang Tan ◽  
Chunhong Chen ◽  
Shanjun Mao ◽  
Zhe Wang ◽  
Yiyao Ge ◽  
...  
Keyword(s):  
Hybrid Nanostructures ◽  
Ordered Mesoporous ◽  
General Synthesis

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

A general synthesis approach in action: preparation and characterization of polyoxomolybdenum(vi) organophosphonates through oxidative Mo–Mo bond cleavage in {MoV2O4}

CrystEngComm ◽  
2012 ◽  
Vol 14 (14) ◽  
pp. 4826 ◽  
Author(s):  
Lijuan Zhang ◽  
Jingmei Sun ◽  
Yunshan Zhou ◽  
Sadaf ul Hassan ◽  
Enbo Wang ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Action Preparation ◽  
General Synthesis ◽  
Synthesis Approach

ChemInform Abstract: A General Synthesis of Dialkyl 1-(Triorganostannyl)alkylphosphonates.

ChemInform ◽  
2010 ◽  
Vol 22 (36) ◽  
pp. no-no
Author(s):  
N. MIMOUNI ◽  
E. ABOUT-JAUDET ◽  
N. COLLIGNON
Keyword(s):  
General Synthesis
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