Sensitivity-Enhanced Solid-State NMR Detection of Structural Differences and Unique Polymorphs in Pico- to Nanomolar Amounts of Brain-Derived and Synthetic 42-Residue Amyloid-β Fibrils

2021 ◽  
Author(s):  
Ayesha Wickramasinghe ◽  
Yiling Xiao ◽  
Naohiro Kobayashi ◽  
Songlin Wang ◽  
Kathryn P. Scherpelz ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Β ◽  
Structural Differences

scholarly journals Solid-State NMR Reveals Structural Differences between Fibrils of Wild-Type and Disease-Related A53T Mutant α-Synuclein

2008 ◽  
Vol 380 (3) ◽  
pp. 444-450 ◽  
Author(s):  
Henrike Heise ◽  
M. Soledad Celej ◽  
Stefan Becker ◽  
Dietmar Riedel ◽  
Avishay Pelah ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Wild Type ◽  
Structural Differences

scholarly journals Solid-state NMR sequential assignment of an Amyloid-β(1–42) fibril polymorph

2016 ◽  
Vol 10 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Francesco Ravotti ◽  
Marielle Aulikki Wälti ◽  
Peter Güntert ◽  
Roland Riek ◽  
Anja Böckmann ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Β ◽  
Sequential Assignment

scholarly journals Solid-state NMR Reveals a Close Structural Relationship between Amyloid-β Protofibrils and Oligomers

2012 ◽  
Vol 287 (27) ◽  
pp. 22822-22826 ◽  
Author(s):  
Holger A. Scheidt ◽  
Isabel Morgado ◽  
Daniel Huster
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Β ◽  
Structural Relationship

Association of amyloid-β peptide with membrane surfaces monitored by solid state NMR

2002 ◽  
Vol 4 (22) ◽  
pp. 5524-5530 ◽  
Author(s):  
Fredrick Lindström ◽  
Marcus Bokvist ◽  
Tobias Sparrman ◽  
Gerhard Gröbner
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Membrane Surfaces

Tripeptides on Gold Nanoparticles: Structural Differences between Two Reverse Sequences as Determined by Solid-State NMR and DFT Calculations

2015 ◽  
Vol 119 (36) ◽  
pp. 11998-12006 ◽  
Author(s):  
Ichhuk Karki ◽  
Hong Wang ◽  
Natalie R. Geise ◽  
Brendan W. Wilson ◽  
James P. Lewis ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Solid State ◽  
Dft Calculations ◽  
Solid State Nmr ◽  
Structural Differences

scholarly journals A Combined 25 Mg Solid‐State NMR and Ab Initio DFT Approach to Probe the Local Structural Differences in Magnesium Acetate Phases Mg(CH 3 COO) 2  ⋅ nH 2 O (n=0, 1, 4)

ChemPhysChem ◽  
2018 ◽  
Vol 19 (14) ◽  
pp. 1722-1732 ◽  
Author(s):  
Valerie R. Seymour ◽  
Stephen P. Day ◽  
Gudrun Scholz ◽  
Kerstin Scheurell ◽  
Dinu Iuga ◽  
...  
Keyword(s):  
Solid State ◽  
Ab Initio ◽  
Solid State Nmr ◽  
Magnesium Acetate ◽  
Structural Differences ◽  
Ab Initio Dft

scholarly journals Structural characteristics of oligomers formed by pyroglutamate-modified amyloid β peptides studied by solid-state NMR

2020 ◽  
Vol 22 (29) ◽  
pp. 16887-16895 ◽  
Author(s):  
Holger A. Scheidt ◽  
Anirban Das ◽  
Alexander Korn ◽  
Martin Krueger ◽  
Sudipta Maiti ◽  
...  
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Structural Characteristics ◽  
Amyloid Β ◽  
Wild Type

Structure of oligomers of truncated and pyroglutamate modified amyloid β variants is similar to the wild type.

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