scholarly journals High-Fidelity Sequence-Selective Duplex Formation by Recognition-Encoded Melamine Oligomers

2021 ◽  
Author(s):  
Pavle Troselj ◽  
Peter Bolgar ◽  
Pablo Ballester ◽  
Christopher A. Hunter
Keyword(s):  
High Fidelity ◽  
Duplex Formation

scholarly journals Stability of local secondary structure determines selectivity of viral RNA chaperones

2018 ◽  
Author(s):  
Jack P.K. Bravo ◽  
Alexander Borodavka ◽  
Anders Barth ◽  
Antonio N. Calabrese ◽  
Peter Mojzes ◽  
...  
Keyword(s):  
Rna Structure ◽  
Rna Binding ◽  
High Fidelity ◽  
Multiple Sequence ◽  
Genomic Rnas ◽  
Local Secondary Structure ◽  
Complete Set ◽  
Rna Chaperones ◽  
Duplex Formation ◽  
Segmented Genome

AbstractTo maintain genome integrity, segmented double-stranded RNA viruses of theReoviridaefamily must accurately select and package a complete set of up to a dozen distinct genomic RNAs. It is thought that the high fidelity segmented genome assembly involves multiple sequence-specific RNA-RNA interactions between single-stranded RNA segment precursors. These are mediated by virus-encoded non-structural proteins with RNA chaperone-like activities, such as rotavirus NSP2 and avian reovirus σNS. Here, we compared the abilities of NSP2 and σNS to mediate sequence-specific interactions between rotavirus genomic segment precursors. Despite their similar activities, NSP2 successfully promotes inter-segment association, while σNS fails to do so. To understand the mechanisms underlying such selectivity in promoting inter-molecular duplex formation, we compared RNA-binding and helix-unwinding activities of both proteins. We demonstrate that octameric NSP2 binds structured RNAs with high affinity, resulting in efficient intramolecular RNA helix disruption. Hexameric σNS oligomerises into an octamer that binds two RNAs, yet it exhibits only limited RNA-unwinding activity compared to NSP2. Thus, the formation of intersegment RNA-RNA interactions is governed by both helix-unwinding capacity of the chaperones and stability of RNA structure. We propose that this protein-mediated RNA selection mechanism may underpin the high fidelity assembly of multi-segmented RNA genomes inReoviridae.

Using the Theory of Planned Behavior to Predict Faking in Selection Exercises Varying in Fidelity

2018 ◽  
Vol 17 (3) ◽  
pp. 155-160 ◽  
Author(s):  
Daniel Dürr ◽  
Ute-Christine Klehe
Keyword(s):  
Theory Of Planned Behavior ◽  
Planned Behavior ◽  
Predictive Validity ◽  
Group Discussion ◽  
Role Play ◽  
Selection Procedure ◽  
High Fidelity ◽  
Selection Research ◽  
Play Group

Abstract. Faking has been a concern in selection research for many years. Many studies have examined faking in questionnaires while far less is known about faking in selection exercises with higher fidelity. This study applies the theory of planned behavior (TPB; Ajzen, 1991 ) to low- (interviews) and high-fidelity (role play, group discussion) exercises, testing whether the TPB predicts reported faking behavior. Data from a mock selection procedure suggests that candidates do report to fake in low- and high-fidelity exercises. Additionally, the TPB showed good predictive validity for faking in a low-fidelity exercise, yet not for faking in high-fidelity exercises.

The effects of a high fidelity vibro-kinetic multisensory experience on implicit and explicit brand recognition.

2019 ◽  
Vol 12 (1) ◽  
pp. 18-33 ◽  
Author(s):  
Horea Pauna ◽  
Pierre-Majorique Léger ◽  
Sylvain Sénécal ◽  
Marc Fredette ◽  
Élise Labonté-Lemoyne ◽  
...  
Keyword(s):  
High Fidelity ◽  
Brand Recognition ◽  
Implicit And Explicit ◽  
Multisensory Experience

A high-fidelity dynamic model for the Active Rack Isolation System

1998 ◽  
Author(s):  
R. Hampton ◽  
Nagendra Subba Rao ◽  
Young Kim ◽  
William Wagar ◽  
Allen Karchmer
Keyword(s):  
Dynamic Model ◽  
High Fidelity ◽  
Isolation System

High Fidelity Response and Failure Evaluation of Tapered Composite Components under Multiaxial Loading

2021 ◽  
Author(s):  
Jian Xiao ◽  
Phillip Liu ◽  
D.C. Pham ◽  
Jim Lua ◽  
Shenal Perera ◽  
...  
Keyword(s):  
High Fidelity ◽  
Multiaxial Loading ◽  
Failure Evaluation

Challenges Towards Developing a High Fidelity Database for Validating High Strain Rate Composite Material Models

2021 ◽  
Author(s):  
Mark Pankow ◽  
Joseph Giliberto ◽  
Brandon Hearley ◽  
Brian Justusson ◽  
Joseph Schaefer ◽  
...  
Keyword(s):  
Composite Material ◽  
High Strain Rate ◽  
Strain Rate ◽  
High Strain ◽  
High Fidelity ◽  
Material Models
Sign in / Sign up

Export Citation Format

Share Document