scholarly journals A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment

2021 ◽  
Author(s):  
Li-Jun Chen ◽  
Sean J. Humphrey ◽  
Jun-Long Zhu ◽  
Fan-Fan Zhu ◽  
Xu-Qing Wang ◽  
...  
Keyword(s):  
Two Dimensional ◽  
Highly Efficient ◽  
Peptide Enrichment ◽  
Phosphorylated Peptide

scholarly journals A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment

2019 ◽  
Author(s):  
Li-Jun Chen ◽  
jun-long zhu ◽  
Fan-Fan Zhu ◽  
Jin Wen ◽  
Hai-Bo Yang ◽  
...  
Keyword(s):  
Detection Sensitivity ◽  
Supramolecular Polymer ◽  
Two Dimensional ◽  
Phosphopeptide Enrichment ◽  
Stimuli Responsive ◽  
Excellent Performance ◽  
High Enrichment ◽  
Peptide Enrichment ◽  
Phosphorylated Peptide ◽  
Positively Charged

The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. However, this remains a significant challenge due to the inherently low abundance of these species in complex bio-samples. In this paper, we report a switchable two-dimensional (2D) supramolecular polymer that can serve as an ideal platform for the enrichment of phosphopeptides. A positively charged metallacycle incorporated into the polymer endows the material with a high affinity for phosphopeptides. Importantly, the stimuli-responsive nature of the polymer facilitates switchable binding affinity of phosphopeptides, resulting in its excellent performance in phosphopeptide enrichment and separation from model proteins. The polymer has a high enrichment capacity (165 mg/g) and detection sensitivity (2 fmol), high enrichment recovery (88%), excellent specificity, and rapid enrichment and separation properties. Additionally, we have demonstrated the capture of phosphopeptides from the tryptic digest of real bio-samples illustrating the potential of this polymeric material in phosphoproteomic studies.

scholarly journals A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment

2020 ◽  
Author(s):  
Li-Jun Chen ◽  
jun-long zhu ◽  
Fan-Fan Zhu ◽  
Xu-Qing Wang ◽  
Jin Wen ◽  
...  
Keyword(s):  
Detection Sensitivity ◽  
Supramolecular Polymer ◽  
Two Dimensional ◽  
Phosphopeptide Enrichment ◽  
Stimuli Responsive ◽  
Excellent Performance ◽  
High Enrichment ◽  
Peptide Enrichment ◽  
Phosphorylated Peptide ◽  
Positively Charged

<p>The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. However, this remains a significant challenge due to the inherently low abundance of these species in complex bio-samples. In this paper, we report a switchable two-dimensional (2D) supramolecular polymer that can serve as an ideal platform for the enrichment of phosphopeptides. A positively charged metallacycle incorporated into the polymer endows the material with a high affinity for phosphopeptides. Importantly, the stimuli-responsive nature of the polymer facilitates switchable binding affinity of phosphopeptides, resulting in its excellent performance in phosphopeptide enrichment and separation from model proteins. The polymer has a high enrichment capacity (165 mg/g) and detection sensitivity (2 fmol), high enrichment recovery (88%), excellent specificity, and rapid enrichment and separation properties. Additionally, we have demonstrated the capture of phosphopeptides from the tryptic digest of real bio-samples illustrating the potential of this polymeric material in phosphoproteomic studies.</p>

scholarly journals A Two-Dimensional Metallacycle Cross-Linked Switchable Polymer for Fast and Highly Efficient Phosphorylated Peptide Enrichment

2020 ◽  
Author(s):  
Li-Jun Chen ◽  
jun-long zhu ◽  
Fan-Fan Zhu ◽  
Xu-Qing Wang ◽  
Jin Wen ◽  
...  
Keyword(s):  
Detection Sensitivity ◽  
Supramolecular Polymer ◽  
Two Dimensional ◽  
Phosphopeptide Enrichment ◽  
Stimuli Responsive ◽  
Excellent Performance ◽  
High Enrichment ◽  
Peptide Enrichment ◽  
Phosphorylated Peptide ◽  
Positively Charged

<p>The selective and efficient capture of phosphopeptides is critical for comprehensive and in-depth phosphoproteome analysis. However, this remains a significant challenge due to the inherently low abundance of these species in complex bio-samples. In this paper, we report a switchable two-dimensional (2D) supramolecular polymer that can serve as an ideal platform for the enrichment of phosphopeptides. A positively charged metallacycle incorporated into the polymer endows the material with a high affinity for phosphopeptides. Importantly, the stimuli-responsive nature of the polymer facilitates switchable binding affinity of phosphopeptides, resulting in its excellent performance in phosphopeptide enrichment and separation from model proteins. The polymer has a high enrichment capacity (165 mg/g) and detection sensitivity (2 fmol), high enrichment recovery (88%), excellent specificity, and rapid enrichment and separation properties. Additionally, we have demonstrated the capture of phosphopeptides from the tryptic digest of real bio-samples illustrating the potential of this polymeric material in phosphoproteomic studies.</p>

scholarly journals Lanthanide doped two dimensional heterostructure nanosheets with highly efficient harvest towards solar energy

2021 ◽  
pp. 110023
Author(s):  
Youqiang Huang ◽  
Yingjie Zhao ◽  
Yuan Liu ◽  
Beibei Xu ◽  
Shiqing Xu ◽  
...  
Keyword(s):  
Solar Energy ◽  
Two Dimensional ◽  
Highly Efficient

scholarly journals Enhanced electrochemical activities of morphologically tuned MnFe2O4 nanoneedles and nanoparticles integrated on reduced graphene oxide for highly efficient supercapacitor electrodes

2021 ◽  
Author(s):  
R Rajalakshmi ◽  
Remya K. P. ◽  
Viswanathan Chinnuswamy ◽  
Nagamony Ponpandian
Keyword(s):  
Graphene Oxide ◽  
Physicochemical Properties ◽  
Reduced Graphene Oxide ◽  
Two Dimensional ◽  
2D Material ◽  
Highly Efficient ◽  
Reduced Graphene

The morphology of a nanoparticle strongly controls the path ofelectronic interaction, which directly correlates to the physicochemical properties and also the electrochemical comportment. Conjoining it with a two-dimensional (2D) material...

Highly efficient in-plane channel drop filter in a two-dimensional heterophotonic crystal

2005 ◽  
Vol 86 (24) ◽  
pp. 241101 ◽  
Author(s):  
Hitomichi Takano ◽  
Bong-Shik Song ◽  
Takashi Asano ◽  
Susumu Noda
Keyword(s):  
Plane Channel ◽  
Two Dimensional ◽  
Highly Efficient

Quaternary two dimensional Zn–Ag–In–S nanosheets for highly efficient photocatalytic hydrogen generation

2018 ◽  
Vol 6 (25) ◽  
pp. 11670-11675 ◽  
Author(s):  
Hao Chen ◽  
Xiao-Yuan Liu ◽  
Shizhuo Wang ◽  
Xu Wang ◽  
Qi Wei ◽  
...  
Keyword(s):  
Renewable Energy ◽  
Water Splitting ◽  
Energy Production ◽  
Hydrogen Generation ◽  
Two Dimensional ◽  
Photocatalytic Water Splitting ◽  
Highly Efficient ◽  
Photocatalytic Hydrogen Generation ◽  
Promising Strategy ◽  
Renewable Energy Production

Hydrogen generation based on photocatalytic water splitting is a promising strategy for renewable energy production.

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