Truncated Actin-Targeting Macrolide Derivative Blocks Cancer Cell Motility and Invasion of Extracellular Matrix

2021 ◽  
Author(s):  
Bhavin V. Pipaliya ◽  
Daria N. Trofimova ◽  
Rebecca L. Grange ◽  
Madhu Aeluri ◽  
Xu Deng ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Motility ◽  
Cancer Cell ◽  
Cancer Cell Motility

scholarly journals Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility

2016 ◽  
Vol 372 (2) ◽  
pp. 210-218 ◽  
Author(s):  
Masafumi Sada ◽  
Kenoki Ohuchida ◽  
Kohei Horioka ◽  
Takashi Okumura ◽  
Taiki Moriyama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Extracellular Matrix ◽  
Cell Motility ◽  
Cancer Cell ◽  
Stellate Cells ◽  
Cancer Cell Motility ◽  
Cancer Stroma ◽  
Fiber Organization

scholarly journals Adhesion and Migration Response to Radiation Therapy of Mammary Epithelial and Adenocarcinoma Cells Interacting with Different Stiffness Substrates

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1170
Author(s):  
Valeria Panzetta ◽  
Giuseppe La Verde ◽  
Mariagabriella Pugliese ◽  
Valeria Artiola ◽  
Cecilia Arrichiello ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Motility ◽  
Tumor Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Matrix Stiffness ◽  
Cancer Cell Motility ◽  
Tumor Cell Motility ◽  
Extracellular Matrix Stiffness ◽  
And Migration

The structural and mechanical properties of the microenvironmental context have a profound impact on cancer cell motility, tumor invasion, and metastasis formation. In fact, cells react to their mechanical environment modulating their adhesion, cytoskeleton organization, changes of shape, and, consequently, the dynamics of their motility. In order to elucidate the role of extracellular matrix stiffness as a driving force in cancer cell motility/invasion and the effects of ionizing radiations on these processes, we evaluated adhesion and migration as biophysical properties of two different mammary cell lines, over a range of pathophysiological stiffness (1–13 kPa) in a control condition and after the exposure to two different X-ray doses (2 and 10 Gy, photon beams). We concluded that the microenvironment mimicking the normal mechanics of healthy tissue has a radioprotective role on both cell lines, preventing cell motility and invasion. Supraphysiological extracellular matrix stiffness promoted tumor cell motility instead, but also had a normalizing effect on the response to radiation of tumor cells, lowering their migratory capability. This work lays the foundation for exploiting the extracellular matrix-mediated mechanism underlying the response of healthy and tumor cells to radiation treatments and opens new frontiers in the diagnostic and therapeutic use of radiotherapy.

scholarly journals Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion

2021 ◽  
Vol 15 (1) ◽  
pp. 37-57
Author(s):  
Wishrawana S. Ratnayake ◽  
Christopher A. Apostolatos ◽  
Sloan Breedy ◽  
Clare L. Dennison ◽  
Robert Hill ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Motility ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Motility

scholarly journals Pin1 Is Involved in HDAC6-mediated Cancer Cell Motility

2018 ◽  
Vol 15 (13) ◽  
pp. 1573-1581 ◽  
Author(s):  
Hsiang-Hao Chuang ◽  
Ming-Shyan Huang ◽  
Pei-Hui Wang ◽  
Yu-Peng Liu ◽  
Michael Hsiao ◽  
...  
Keyword(s):  
Cell Motility ◽  
Cancer Cell ◽  
Cancer Cell Motility
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