scholarly journals Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction

2020 ◽  
Vol 142 (35) ◽  
pp. 14933-14939
Author(s):  
Dillon P. Cogan ◽  
Xiuyuan Li ◽  
Natalia Sevillano ◽  
Irimpan I. Mathews ◽  
Tsutomu Matsui ◽  
...  
Keyword(s):  
Extended Conformation ◽  
Deoxyerythronolide B Synthase

scholarly journals Ligand-induced conformational rearrangements regulate the switch between membrane-proximal and distal functions of Rho kinase 2

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
István Hajdú ◽  
András Szilágyi ◽  
Barbara M. Végh ◽  
András Wacha ◽  
Dániel Györffy ◽  
...  
Keyword(s):  
Structural Model ◽  
Coiled Coil ◽  
Rho Kinase ◽  
Mechanistic Explanation ◽  
Kinase Domain ◽  
Multifunctional Protein ◽  
Regulatory Domains ◽  
Extended Conformation ◽  
Activity Measurements ◽  
Present Solution

AbstractRho-associated protein kinase 2 (ROCK2) is a membrane-anchored, long, flexible, multidomain, multifunctional protein. Its functions can be divided into two categories: membrane-proximal and membrane-distal. A recent study concluded that membrane-distal functions require the fully extended conformation, and this conclusion was supported by electron microscopy. The present solution small-angle X-ray scattering (SAXS) study revealed that ROCK2 population is a dynamic mixture of folded and partially extended conformers. Binding of RhoA to the coiled-coil domain shifts the equilibrium towards the partially extended state. Enzyme activity measurements suggest that the binding of natural protein substrates to the kinase domain breaks up the interaction between the N-terminal kinase and C-terminal regulatory domains, but smaller substrate analogues do not. The present study reveals the dynamic behaviour of this long, dimeric molecule in solution, and our structural model provides a mechanistic explanation for a set of membrane-proximal functions while allowing for the existence of an extended conformation in the case of membrane-distal functions.

NanoMuscle: controllable contraction and extension of mechanically interlocked DNA origami

Nanoscale ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 2992-2998 ◽  
Author(s):  
Yu-Chen Chao ◽  
Yu-Jun Hong ◽  
Chieh-Yu Lee ◽  
Shao-Chien Zhuang ◽  
Meng-Ting Wu ◽  
...  
Keyword(s):  
Dna Origami ◽  
Extended Conformation

NanoMuscle is able to switch between its thermodynamic bistable states, where each state corresponds to NanoMuscle's contracted or extended conformation.

scholarly journals Crystal structure of (E)-4-{[2-(2,4-dinitrophenyl)hydrazin-1-ylidene]methyl}-3-methyl-1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole

2014 ◽  
Vol 70 (12) ◽  
pp. o1246-o1247 ◽  
Author(s):  
Joel T. Mague ◽  
Shaaban K. Mohamed ◽  
Mehmet Akkurt ◽  
Hussein M. S. El-Kashef ◽  
Mustafa R. Albayati
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Title Compound ◽  
Pyrazole Ring ◽  
Dihedral Angles ◽  
Extended Conformation ◽  
Compound C ◽  
Benzene Rings

The title compound, C21H17N7O4, is in an `extended' conformation aided by an intramolecular N—H...O hydrogen bond. The pyrazole ring makes dihedral angles of 29.17 (6), 65.47 (4) and 9.91 (7)°, respectively, with the phenyl, pyrrole and benzene rings. In the crystal, molecules are connected by pairs of N—H...O and C—H...O hydrogen bonds, forming inversion dimers which associate into ribbons running along thebaxis through complementary C—H...O interactions.

scholarly journals Structure–Function Analysis of the Extended Conformation of a Polyketide Synthase Module

2018 ◽  
Vol 140 (21) ◽  
pp. 6518-6521 ◽  
Author(s):  
Xiuyuan Li ◽  
Natalia Sevillano ◽  
Florencia La Greca ◽  
Lindsay Deis ◽  
Yu-Chen Liu ◽  
...  
Keyword(s):  
Structure Function ◽  
Polyketide Synthase ◽  
Function Analysis ◽  
Extended Conformation

scholarly journals NADPH-dependent sulfite reductase flavoprotein adopts an extended conformation unique to this diflavin reductase

2019 ◽  
Vol 205 (2) ◽  
pp. 170-179
Author(s):  
Angela M. Tavolieri ◽  
Daniel T. Murray ◽  
Isabel Askenasy ◽  
Joseph M. Pennington ◽  
Lauren McGarry ◽  
...  
Keyword(s):  
Sulfite Reductase ◽  
Extended Conformation

Conformational behavior of C?,?-diphenyl glycine: Extended conformation in tripeptides containing consecutive D?g residues

Biopolymers ◽  
2000 ◽  
Vol 53 (2) ◽  
pp. 161-168 ◽  
Author(s):  
Vincenzo Pavone ◽  
Angela Lombardi ◽  
Michele Saviano ◽  
Giuseppina De Simone ◽  
Flavia Nastri ◽  
...  
Keyword(s):  
Conformational Behavior ◽  
Extended Conformation
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